Rad51 Protein Controls Rad52-mediated DNA Annealing
TLDR
Regulation of Rad52-mediated annealing suggests a control function for Rad51 in deciding the recombination path taken for a processed DNA break; the ssDNA can be directed to either Rad51-mediated DNA strand invasion or to Rad 52- mediated DNA annealed.About:
This article is published in Journal of Biological Chemistry.The article was published on 2008-05-23 and is currently open access. It has received 93 citations till now. The article focuses on the topics: Replication protein A & Strand invasion.read more
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疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
TL;DR: PfPMP1）与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作�ly.
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Repair Pathway Choices and Consequences at the Double-Strand Break
TL;DR: Alternative error-prone DSB repair pathways, namely alternative end joining (alt-EJ) and single-strand annealing (SSA) have been recently shown to operate in many different conditions and to contribute to genome rearrangements and oncogenic transformation.
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Regulation of homologous recombination in eukaryotes
TL;DR: The factors and mechanistic stages of recombination that are subject to regulation are reviewed and it is suggested that recombination achieves flexibility and robustness by proceeding through metastable, reversible intermediates.
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A Microhomology-Mediated Break-Induced Replication Model for the Origin of Human Copy Number Variation
TL;DR: It is proposed that breakage of replication forks in stressed cells that are deficient in homologous recombination induces an aberrant repair process with features of break-induced replication (BIR) that will anneal with microhomology on any single-stranded DNA nearby, priming low-processivity polymerization with multiple template switches generating complex rearrangements, and eventual re-establishment of processive replication.
References
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Dna strand exchange proteins: a biochemical and physical comparison
TL;DR: This review focuses on the biochemical and physical characteristics of DNA strand exchange proteins from three diverse organisms: RecA protein from E. coli, UvsX protein from Bacteriophage T4, and RAD51 protein from Saccharomyces cerevisiae.
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Characterization of double-strand break-induced recombination: homology requirements and single-stranded DNA formation
Neal Sugawara,James E. Haber +1 more
TL;DR: It is determined that recombination initiated by a double-strand break requires a minimum homologous length between 63 and 89 bp, and the frequency of recombination was dependent on the length of homology in an approximately linear manner.
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Genetic Requirements for the Single-Strand Annealing Pathway of Double-Strand Break Repair in Saccharomyces cerevisiae
TL;DR: There is a competition between SSA and gene conversion processes that favors SSA in the absence of RAD51, RAD54, RAD55 and RAD57, a result resembling the effects of these genes during mating-type (MAT) switching.
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In vivo roles of Rad52, Rad54, and Rad55 proteins in Rad51-mediated recombination.
TL;DR: Ch chromatin immunoprecipitation is used to monitor the in vivo association of Saccharomyces cerevisiae Rad51p with both the cleaved MATa locus and the HML alpha donor, providing evidence of the time needed for the Rad51 filament to search the genome for a homologous sequence.
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Human DNA Polymerase η Promotes DNA Synthesis from Strand Invasion Intermediates of Homologous Recombination
Michael J. McIlwraith,Alexandra Vaisman,Yilun Liu,Ellen Fanning,Roger Woodgate,Stephen C. West +5 more
TL;DR: The results indicate a dual function for poleta at stalled replication forks: the promotion of translesion synthesis and the reinitiation of DNA synthesis by homologous recombination repair.