Rad51 Protein Controls Rad52-mediated DNA Annealing
TLDR
Regulation of Rad52-mediated annealing suggests a control function for Rad51 in deciding the recombination path taken for a processed DNA break; the ssDNA can be directed to either Rad51-mediated DNA strand invasion or to Rad 52- mediated DNA annealed.About:
This article is published in Journal of Biological Chemistry.The article was published on 2008-05-23 and is currently open access. It has received 93 citations till now. The article focuses on the topics: Replication protein A & Strand invasion.read more
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疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
TL;DR: PfPMP1）与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作�ly.
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Repair Pathway Choices and Consequences at the Double-Strand Break
TL;DR: Alternative error-prone DSB repair pathways, namely alternative end joining (alt-EJ) and single-strand annealing (SSA) have been recently shown to operate in many different conditions and to contribute to genome rearrangements and oncogenic transformation.
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Regulation of homologous recombination in eukaryotes
TL;DR: The factors and mechanistic stages of recombination that are subject to regulation are reviewed and it is suggested that recombination achieves flexibility and robustness by proceeding through metastable, reversible intermediates.
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A Microhomology-Mediated Break-Induced Replication Model for the Origin of Human Copy Number Variation
TL;DR: It is proposed that breakage of replication forks in stressed cells that are deficient in homologous recombination induces an aberrant repair process with features of break-induced replication (BIR) that will anneal with microhomology on any single-stranded DNA nearby, priming low-processivity polymerization with multiple template switches generating complex rearrangements, and eventual re-establishment of processive replication.
References
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Characterization of RAD51-independent break-induced replication that acts preferentially with short homologous sequences
Grzegorz Ira,James E. Haber +1 more
TL;DR: The differences between the RAD51- and RAD50/RAD59-dependent pathways account for the distinct ways that two different recombination processes maintain yeast telomeres in the absence of telomerase.
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Rad54 protein is targeted to pairing loci by the Rad51 nucleoprotein filament.
Alexander V. Mazin,Carole J. Bornarth,Jachen A. Solinger,Wolf Dietrich Heyer,Stephen C. Kowalczykowski +4 more
TL;DR: It is demonstrated that Rad54 acts in concert with the mature Rad51-ssDNA filament and that the filament delivers Rad54 to the dsDNA pairing locus, thereby linking the unwinding of potential target DNA with the homology search process.
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A novel function of Rad54 protein. Stabilization of the Rad51 nucleoprotein filament.
TL;DR: In this paper, the Rad54-Rad51-DNA nucleoprotein co-complex was shown to stabilize the Rad51 nucleopprotein filament, a biochemical entity central to homologous recombination.
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Homologous pairing promoted by the human Rad52 protein.
TL;DR: The biochemically characterized the homologous pairing activity of the HsRad52 protein and found that the presynaptic complex formation with ssDNA is essential in its catalysis of homologueous pairing.
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Multiple Pathways for Homologous Recombination in Saccharomyces Cerevisiae
TL;DR: There is still considerably more recombination in rad1 rad51 mutants than in rad52 mutants, indicating the presence of another, as yet unidentified, recombination pathway.