Rad51 Protein Controls Rad52-mediated DNA Annealing
TLDR
Regulation of Rad52-mediated annealing suggests a control function for Rad51 in deciding the recombination path taken for a processed DNA break; the ssDNA can be directed to either Rad51-mediated DNA strand invasion or to Rad 52- mediated DNA annealed.About:
This article is published in Journal of Biological Chemistry.The article was published on 2008-05-23 and is currently open access. It has received 93 citations till now. The article focuses on the topics: Replication protein A & Strand invasion.read more
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Rad52 oligomeric N-terminal domain stabilizes Rad51 nucleoprotein filaments and contributes to their protection against Srs2
TL;DR: In this article, mutations in Rad52 Nterminal domain also suppress the DNA damage sensitivity of Srs2-deficient cells without disturbing Rad52 mediator and pairing activity, both in vivo and in vitro.
Impact of single strand annealing on double strand break repair and chromosomal stability in mammalian cells: A component of the repair network
TL;DR: In this paper, the authors proposed a functional hierarchy for DSB repair network in mammalian cells and showed that NHEJ dominates and suppresses the other two repair pathways, while SSA does not.
Estratégias para o aumento na eficiência de produção de suínos geneticamente modificados
TL;DR: This study aimed to increase the efficiency in the production of porcine embryos using SCNT cloning by selecting oocytes in less subjective ways, by increasing the parthenogenetic activation efficiency using zinc chelators, and by improving embryo production by exposing cloned embryos to a histone deacetylase inhibitor.
References
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疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
TL;DR: PfPMP1）与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作�ly.
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Multiple Pathways of Recombination Induced by Double-Strand Breaks in Saccharomyces cerevisiae
Frédéric Pâques,James E. Haber +1 more
TL;DR: This review encompasses different aspects of DSB-induced recombination in Saccharomyces and attempts to relate genetic, molecular biological, and biochemical studies of the processes of DNA repair and recombination.
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Role of RAD52 Epistasis Group Genes in Homologous Recombination and Double-Strand Break Repair
TL;DR: An overview of recent biochemical and structural analyses of the Rad52 group proteins is provided and how this information can be incorporated into genetic studies of recombination is discussed.
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Choreography of the DNA damage response: Spatiotemporal relationships among checkpoint and repair proteins
TL;DR: The cellular response to DSBs and DNA replication stress is likely directed by the Mre11 complex detecting and processing DNA ends in conjunction with Sae2 and by RP-A recognizing single-stranded DNA and recruiting additional checkpoint and repair proteins.
Journal ArticleDOI
DNA helicase Srs2 disrupts the Rad51 presynaptic filament
Lumir Krejci,Stephen Van Komen,Ying Li,Jana Villemain,Mothe Sreedhar Reddy,Hannah L. Klein,Thomas E. Ellenberger,Patrick Sung +7 more
TL;DR: The role of SRS2 in recombination modulation is clarified by purifying its encoded product and examining its interactions with the Rad51 recombinase, and it is shown that Srs2 acts by dislodging Rad51 from ssDNA.