Rad51 Protein Controls Rad52-mediated DNA Annealing
TLDR
Regulation of Rad52-mediated annealing suggests a control function for Rad51 in deciding the recombination path taken for a processed DNA break; the ssDNA can be directed to either Rad51-mediated DNA strand invasion or to Rad 52- mediated DNA annealed.About:
This article is published in Journal of Biological Chemistry.The article was published on 2008-05-23 and is currently open access. It has received 93 citations till now. The article focuses on the topics: Replication protein A & Strand invasion.read more
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疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
TL;DR: PfPMP1）与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作�ly.
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Repair Pathway Choices and Consequences at the Double-Strand Break
TL;DR: Alternative error-prone DSB repair pathways, namely alternative end joining (alt-EJ) and single-strand annealing (SSA) have been recently shown to operate in many different conditions and to contribute to genome rearrangements and oncogenic transformation.
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Regulation of homologous recombination in eukaryotes
TL;DR: The factors and mechanistic stages of recombination that are subject to regulation are reviewed and it is suggested that recombination achieves flexibility and robustness by proceeding through metastable, reversible intermediates.
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A Microhomology-Mediated Break-Induced Replication Model for the Origin of Human Copy Number Variation
TL;DR: It is proposed that breakage of replication forks in stressed cells that are deficient in homologous recombination induces an aberrant repair process with features of break-induced replication (BIR) that will anneal with microhomology on any single-stranded DNA nearby, priming low-processivity polymerization with multiple template switches generating complex rearrangements, and eventual re-establishment of processive replication.
References
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Srs2 and Sgs1-Top3 suppress crossovers during double-strand break repair in yeast.
TL;DR: Sgs1 and its associated topoisomerase Top3 remove double Holliday junction intermediates from a crossover-producing repair pathway, thereby reducing crossovers and Srs2 promotes the noncrossover synthesis-dependent strand-annealing pathway, apparently by regulating Rad51 binding during strand exchange.
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The Srs2 helicase prevents recombination by disrupting Rad51 nucleoprotein filaments.
Xavier Veaute,Josette Jeusset,Christine Soustelle,Stephen C. Kowalczykowski,Eric Le Cam,Francis Fabre +5 more
TL;DR: It is shown that DNA strand exchange mediated in vitro by Rad51 is inhibited by Srs2, and that SRS2 disrupts Rad51 filaments formed on single-stranded DNA, providing an explanation for the anti-recombinogenic role of Srs1 in vivo and highlighting a previously unknown mechanism for recombination control.
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Rad52 protein stimulates DNA strand exchange by Rad51 and replication protein A
TL;DR: It is found that Rad52 protein stimulates DNA strand exchange by targeting Rad51 protein to a complex of replication protein A (RPA) with single-stranded DNA, implying that specific protein–protein interactions between Rad52protein, Rad51protein and RPA are required.
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Function of Yeast Rad52 Protein as a Mediator between Replication Protein A and the Rad51 Recombinase
TL;DR: Rad52 functions as a co-factor for the Rad51 recombinase, acting specifically to overcome the apparent competition by RPA for binding to single-stranded DNA.