Rationale and design of the Cardiovascular Inflammation Reduction Trial: a test of the inflammatory hypothesis of atherothrombosis.
Brendan M. Everett,Aruna D. Pradhan,Aruna D. Pradhan,Daniel H. Solomon,Nina P. Paynter,Jean G. MacFadyen,Elaine Zaharris,Milan Gupta,Michael Clearfield,Peter Libby,Ahmed A. K. Hasan,Robert J. Glynn,Paul M. Ridker +12 more
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If low-dose methotrexate reduces cardiovascular events, CIRT would provide a novel therapeutic approach for the secondary prevention of heart attack, stroke, and cardiovascular death.About:
This article is published in American Heart Journal.The article was published on 2013-08-01 and is currently open access. It has received 347 citations till now. The article focuses on the topics: Myocardial infarction & Rheumatoid arthritis.read more
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Translational atherosclerosis research: From experimental models to coronary artery disease in humans.
TL;DR: Problems in translating findings from the most broadly used murine models of atherosclerosis into clinically feasible therapies and strategies potentially improving the results of clinical trials are discussed.
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Inflammation in human carotid atheroma plaques.
TL;DR: The successive stages of carotid atheroma plaque formation via fatty streak early-stage toward more advanced rupture-prone lesions are reviewed and involvement of cytokines and chemokines and their cellular sources and targets in plaque progression and rupture are documented.
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The prediction of therapy-benefit for individual cardiovascular disease prevention: rationale, implications, and implementation.
TL;DR: Compared with current guidelines, treatment based on predicted therapy-benefit would increase eligibility for therapy among young people with a moderate risk-factor burden and individuals with a high residual risk.
Journal ArticleDOI
Management of Cardiovascular Risk in Patients with Chronic Inflammatory Diseases: Current Evidence and Future Perspectives.
TL;DR: The current level of evidence of the association between CIDs and CVD and cardiovascular risk management recommendations is summarized and perspectives of ongoing and planned trials are discussed in consideration of potential ways to improve primary and secondary CVD prevention in patients with CID.
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Auraptene exerts protective effects on maternal separation stress-induced changes in behavior, hippocampus, heart and serum of mice.
Mehran Arabi,Shohreh Hosseini Nasab,Zahra Lorigooini,Shakiba Nasiri Boroujeni,Seyyed Mohsen Mortazavi,Maryam Anjomshoa,Hossein Amini-Khoei +6 more
TL;DR: In this article, the authors evaluated the possible protective effects of auraptene in these changes focusing on inflammatory response and oxidative state, and concluded that MS is associated with anxiety-like behavior and cellular/molecular modifications in the heart, hippocampus and serum.
References
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Effects of intensive glucose lowering in type 2 diabetes
Hertzel C. Gerstein,Michael Miller,Robert P. Byington,David C. Goff,J. Thomas Bigger,John B. Buse,William C. Cushman,Saul Genuth,Faramarz Ismail-Beigi,Faramarz Ismail-Beigi,Richard H. Grimm,Jeffrey L. Probstfield,Denise G. Simons-Morton,William T. Friedewald +13 more
TL;DR: In this paper, the authors investigated whether intensive therapy to target normal glycated hemoglobin levels would reduce cardiovascular events in patients with type 2 diabetes who had either established cardiovascular disease or additional cardiovascular risk factors.
Journal ArticleDOI
Definition of Metabolic Syndrome Report of the National Heart, Lung, and Blood Institute/American Heart Association Conference on Scientific Issues Related to Definition
TL;DR: Although ATP III identified CVD as the primary clinical outcome of the metabolic syndrome, most people with this syndrome have insulin resistance, which confers increased risk for type 2 diabetes, when diabetes becomes clinically apparent, CVD risk rises sharply.
Journal ArticleDOI
C-Reactive Protein and Other Markers of Inflammation in the Prediction of Cardiovascular Disease in Women
TL;DR: The addition of the measurement of C-reactive protein to screening based on lipid levels may provide an improved method of identifying persons at risk for cardiovascular events.
Journal ArticleDOI
Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein.
Paul M. Ridker,Eleanor Danielson,Jacques Genest,Antonio M. Gotto,Wolfgang Koenig,Peter Libby,Alberto J. Lorenzatti,Jean G. MacFadyen,Børge G. Nordestgaard,James Shepherd,James T. Willerson,Robert J. Glynn +11 more
TL;DR: In this trial of apparently healthy persons without hyperlipidemia but with elevated high-sensitivity C-reactive protein levels, rosuvastatin significantly reduced the incidence of major cardiovascular events.
Journal ArticleDOI
Inflammation, Aspirin, and the Risk of Cardiovascular Disease in Apparently Healthy Men
TL;DR: The reduction associated with the use of aspirin in the risk of a first myocardial infarction appears to be directly related to the level of C-reactive protein, raising the possibility that antiinflammatory agents may have clinical benefits in preventing cardiovascular disease.
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