Rationale and design of the Cardiovascular Inflammation Reduction Trial: a test of the inflammatory hypothesis of atherothrombosis.
Brendan M. Everett,Aruna D. Pradhan,Aruna D. Pradhan,Daniel H. Solomon,Nina P. Paynter,Jean G. MacFadyen,Elaine Zaharris,Milan Gupta,Michael Clearfield,Peter Libby,Ahmed A. K. Hasan,Robert J. Glynn,Paul M. Ridker +12 more
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TLDR
If low-dose methotrexate reduces cardiovascular events, CIRT would provide a novel therapeutic approach for the secondary prevention of heart attack, stroke, and cardiovascular death.About:
This article is published in American Heart Journal.The article was published on 2013-08-01 and is currently open access. It has received 347 citations till now. The article focuses on the topics: Myocardial infarction & Rheumatoid arthritis.read more
Citations
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Journal ArticleDOI
A Role of IL-17 in Rheumatoid Arthritis Patients Complicated With Atherosclerosis
TL;DR: It is hoped that the occurrence and development of atherosclerosis in patients with RA can be diagnosed or prevented in time in the early stage of lesions, and the prevention and treatment of cardiovascular complications in Patients with RACan be enhanced to reduce mortality.
Journal ArticleDOI
Role of IL-37- and IL-37-Treated Dendritic Cells in Acute Coronary Syndrome.
TL;DR: Wang et al. as mentioned in this paper found that IL-37 is elevated and plays a beneficial role in patients with acute coronary syndrome (ACS), and dendritic cells orchestrate both immunity and tolerance, and tolerogenic DCs are characterized by more secretion of immunosuppressive cytokines.
Dissertation
The role of sIL-6R mediated trans-signaling in cardiovascular morbidity in Rheumatoid Arthritis
TL;DR: It is suggested that IL-6 trans-signaling blockade may be beneficial to RA patients, and perhaps for atherosclerosis in the general population, as well as investigated in a cross-sectional study and an observational study.
Posted ContentDOI
Endothelial pannexin 1 channels control inflammation by regulating intracellular calcium
Yang Yang,Yang Yang,Leon J. DeLalio,Angela K. Best,Edgar Macal,Jenna Milstein,Iona Donnelly,Ashley M. Miller,Martin W. McBride,Xiaohong Shu,Michael Koval,Brant E. Isakson,Scott R. Johnstone +12 more
TL;DR: This study provides the first evidence that intracellular Ca2+ regulation via the Panx1 channel induces a feed-forward effect on NFκβ to regulate IL-1β synthesis and release in endothelium during inflammation.
References
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Effects of intensive glucose lowering in type 2 diabetes
Hertzel C. Gerstein,Michael Miller,Robert P. Byington,David C. Goff,J. Thomas Bigger,John B. Buse,William C. Cushman,Saul Genuth,Faramarz Ismail-Beigi,Faramarz Ismail-Beigi,Richard H. Grimm,Jeffrey L. Probstfield,Denise G. Simons-Morton,William T. Friedewald +13 more
TL;DR: In this paper, the authors investigated whether intensive therapy to target normal glycated hemoglobin levels would reduce cardiovascular events in patients with type 2 diabetes who had either established cardiovascular disease or additional cardiovascular risk factors.
Journal ArticleDOI
Definition of Metabolic Syndrome Report of the National Heart, Lung, and Blood Institute/American Heart Association Conference on Scientific Issues Related to Definition
TL;DR: Although ATP III identified CVD as the primary clinical outcome of the metabolic syndrome, most people with this syndrome have insulin resistance, which confers increased risk for type 2 diabetes, when diabetes becomes clinically apparent, CVD risk rises sharply.
Journal ArticleDOI
C-Reactive Protein and Other Markers of Inflammation in the Prediction of Cardiovascular Disease in Women
TL;DR: The addition of the measurement of C-reactive protein to screening based on lipid levels may provide an improved method of identifying persons at risk for cardiovascular events.
Journal ArticleDOI
Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein.
Paul M. Ridker,Eleanor Danielson,Jacques Genest,Antonio M. Gotto,Wolfgang Koenig,Peter Libby,Alberto J. Lorenzatti,Jean G. MacFadyen,Børge G. Nordestgaard,James Shepherd,James T. Willerson,Robert J. Glynn +11 more
TL;DR: In this trial of apparently healthy persons without hyperlipidemia but with elevated high-sensitivity C-reactive protein levels, rosuvastatin significantly reduced the incidence of major cardiovascular events.
Journal ArticleDOI
Inflammation, Aspirin, and the Risk of Cardiovascular Disease in Apparently Healthy Men
TL;DR: The reduction associated with the use of aspirin in the risk of a first myocardial infarction appears to be directly related to the level of C-reactive protein, raising the possibility that antiinflammatory agents may have clinical benefits in preventing cardiovascular disease.
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