Journal ArticleDOI
Realising the European Network of Biodosimetry (RENEB)
Ulrike Kulka,L. Ainsbury,Michael J. Atkinson,Joan Francesc Barquinero,Leonardo Barrios,Christina Beinke,G. Bognar,Alexandra Cucu,Firouz Darroudi,Paola Fattibene,Octávia Monteiro Gil,Eric Gregoire,Valeria Hadjidekova,Siamak Haghdoost,R. Herranz,Alicja Jaworska,Carita Lindholm,Radhia M'kacher,S. Mörtl,Alegría Montoro,J. E. Moquet,Mercedes Moreno,A. Ogbazghi,Ursula Oestreicher,Fabrizio Palitti,Gabriel E. Pantelias,I. Popescu,María Jesús Prieto,Horst Romm,Kai Rothkamm,Laure Sabatier,Sylwester Sommer,Georgia I. Terzoudi,Antonella Testa,Hubert Thierens,François Trompier,I. Turai,Veerle Vandersickel,P. Vaz,P. Voisin,Anne Vral,Finn Ugletveit,Clemens Woda,Andrzej Wojcik +43 more
TLDR
RENEB will provide a mechanism for quick, efficient and reliable support within the European radiation emergency management and concurrently contribute to increased safety in the field of radiation protection.Abstract:
In Europe, a network for biological dosimetry has been created to strengthen the emergency preparedness and response capabilities in case of a large-scale nuclear accident or radiological emergency. Through the RENEB (Realising the European Network of Biodosimetry) project, 23 experienced laboratories from 16 European countries will establish a sustainable network for rapid, comprehensive and standardised biodosimetry provision that would be urgently required in an emergency situation on European ground. The foundation of the network is formed by five main pillars: (1) the ad hoc operational basis, (2) a basis of future developments, (3) an effective quality-management system, (4) arrangements to guarantee long-term sustainability and (5) awareness of the existence of RENEB. RENEB will thus provide a mechanism for quick, efficient and reliable support within the European radiation emergency management. The scientific basis of RENEB will concurrently contribute to increased safety in the field of radiation protection.read more
Citations
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Journal ArticleDOI
Comparison of Established and Emerging Biodosimetry Assays
Kai Rothkamm,Christina Beinke,Horst Romm,Christophe Badie,Yoganand Balagurunathan,Stephen Barnard,N. Bernard,H. Boulay-Greene,Muriel Brengues,A. De Amicis,S. De Sanctis,R. Greither,F. Herodin,A. Jones,Sylwia Kabacik,T. Knie,Ulrike Kulka,Florigio Lista,Patrick Martigne,A. Missel,Jayne Moquet,Ursula Oestreicher,André Peinnequin,Thomas Poyot,U. Roessler,Harry Scherthan,B. Terbrueggen,Hubert Thierens,Marco Valente,Anne Vral,Frederic Zenhausern,Viktor Meineke,H. Braselmann,Michael Abend +33 more
TL;DR: The DCA has been confirmed as the gold standard biodosimetry method, but in situations where speed and throughput are more important than ultimate accuracy, the emerging rapid molecular assays have the potential to become useful triage tools.
Journal ArticleDOI
Automatic scoring of dicentric chromosomes as a tool in large scale radiation accidents
Horst Romm,Elizabeth A. Ainsbury,Stephen Barnard,Leonardo Barrios,Joan Francesc Barquinero,Christina Beinke,M Deperas,Eric Gregoire,Koivistoinen A,Carita Lindholm,Jayne Moquet,Ursula Oestreicher,Roser Puig,Kai Rothkamm,Sylwester Sommer,Hubert Thierens,Veerle Vandersickel,Anne Vral,Andrzej Wojcik +18 more
TL;DR: Semi-automated dicentric scoring is a useful tool in a large scale radiation accident as it enables high throughput screening of samples for fast triage of potentially exposed individuals.
Journal ArticleDOI
RENEB intercomparisons applying the conventional Dicentric Chromosome Assay (DCA).
Ursula Oestreicher,Daniel Samaga,Elizabeth A. Ainsbury,Ana Antunes,Ans Baeyens,Leonardo Barrios,Christina Beinke,P. Beukes,William F. Blakely,Alexandra Cucu,Andrea De Amicis,Julie Depuydt,Stefania De Sanctis,Marina Di Giorgio,Katalin Dobos,Inmaculada Domínguez,Pham Ngoc Duy,Marco E. Espinoza,Farrah Flegal,Markus Figel,Omar García,Octávia Monteiro Gil,Eric Gregoire,C. Guerrero-Carbajal,I. Guclu,Valeria Hadjidekova,M. Prakash Hande,Ulrike Kulka,Jennifer A. Lemon,Carita Lindholm,Florigio Lista,Katalin Lumniczky,Wilner Martínez-López,Nataliya A. Maznyk,Roberta Meschini,Radia M’kacher,Alegría Montoro,Jayne Moquet,Mercedes Moreno,Mihaela Noditi,J. Pajic,Analía Radl,Michelle Ricoul,Horst Romm,Laurence Roy,Laure Sabatier,Natividad Sebastià,Jacobus Slabbert,Sylwester Sommer,Monica Stuck Oliveira,Uma Subramanian,Yumiko Suto,Tran Que,Antonella Testa,Georgia I. Terzoudi,Anne Vral,Ruth C. Wilkins,LusiYanti Yanti,D. Zafiropoulos,Andrzej Wojcik +59 more
TL;DR: In case of a large-scale radiological incident, the pooling of ressources by networks can enhance the rapid classification of individuals in medically relevant treatment groups based on the DCA.
Journal ArticleDOI
Retrospective and emergency dosimetry in response to radiological incidents and nuclear mass-casualty events: A review
TL;DR: In this article, a review of the application of the physical dosimetry techniques of electron paramagnetic resonance (EPR) and luminescence (optically stimulated luminecence, OSL, and thermoluminescence, TL) to determine radiation dose following catastrophic, large-scale radiological events.
Journal ArticleDOI
The first gamma-H2AX biodosimetry intercomparison exercise of the developing European biodosimetry network RENEB
Stephen Barnard,Elizabeth A. Ainsbury,Jenna Al-hafidh,V. Hadjidekova,Rositsa Hristova,Carita Lindholm,O. Monteiro Gil,Jayne Moquet,Mercedes Moreno,Ute Rößler,Hubert Thierens,Charlot Vandevoorde,Anne Vral,Maria Wojewódzka,Kai Rothkamm +14 more
TL;DR: Despite large variations between laboratories in the dose-response relationship for foci induction, the obtained results indicate that the network should be able to use the gamma-H2AX assay for rapidly identifying the most severely exposed individuals within a cohort who could be prioritised for accurate chromosome dosimetry.
References
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