Journal ArticleDOI
Recent Advances in the Total Synthesis of Piperidine and Pyrrolidine Natural Alkaloids with Ring‐Closing Metathesis as a Key Step
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TLDR
The most recent applications of the ring-closing metathesis reaction (RCM) to construct piperidine and pyrrolidine cores for the total synthesis of natural alkaloids are described in this paper.About:
This article is published in European Journal of Organic Chemistry.The article was published on 2003-10-01. It has received 396 citations till now. The article focuses on the topics: Ring-closing metathesis & Piperidine.read more
Citations
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Synthesis of DMJ analogs with seven- and eight-membered iminocyclitols
TL;DR: In this paper, a straightforward synthesis of new hydroxy azepane and azocane with an additional hydroxymethyl side arm (1-deoxymannojirimycin, DMJ analogs) has been achieved from trans-(2S,4R)-4-hydroxyproline via Grignard addition, ring-closing metathesis, and stereoselective osmylation.
Journal ArticleDOI
Enantioselective Synthesis of ent-Sedridine and (+)-Coniine via Proline-Catalyzed Mannich Reaction
TL;DR: Proline-catalyzed three component Mannich reaction using 5-hydroxypentanal as a substrate was achieved in high enantioselectivity to construct a chiral center at C-2 position of 2-substituted piperidine alkaloids as mentioned in this paper.
Journal ArticleDOI
Diastereoselective and enantioselective capture of chiral zinc enolate using nitroolefins: a rapid access to chiral γ-nitro carbonyl compounds
TL;DR: Highly diastereoselective and enantioselectives catalytic capture of chiral zinc enolates using nitroolefins as electrophiles is described, resulting in tandem products γ-nitro ketones.
Book ChapterDOI
The Literature of Heterocyclic Chemistry, Part IX, 2002–2004
TL;DR: In this article, the authors present a review of eight reviews published in Advances in Heterocyclic Chemistry during the period 2002-2004. But the review is limited to general cases (e.g., anomeric effect) as well as when carbohydrates serve as starting compounds for the synthesis of other heterocycles or they are present as fragments of a complex system including another heterocyclia moiety such as a nucleoside.
Journal ArticleDOI
Proline-catalyzed sequential syn-Mannich and [4 + 1]-annulation cascade reactions to form densely functionalized pyrrolidines.
TL;DR: A highly efficient one-pot [4 + 1]-annulation process for the asymmetric synthesis of densely functionalized pyrrolidine derivatives is described, resulting in a highly enantio- and diastereoselective manner.
References
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Journal ArticleDOI
Synthesis and activity of a new generation of ruthenium-based olefin metathesis catalysts coordinated with 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene ligands.
TL;DR: These air- and water-tolerant complexes were shown to exhibit an increased ring-closing metathesis activity at elevated temperature when compared to that of the parent complex 2 and the previously developed complex 3.
Journal ArticleDOI
Recent advances in olefin metathesis and its application in organic synthesis
Robert H. Grubbs,Sukbok Chang +1 more
TL;DR: In this paper, a review of recent advances in olefin metathesis focusing on the areas of ring-closing olefi cation (RCM) and cross-metathesis is presented.
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Olefin Metathesis and Beyond
TL;DR: In this paper, the authors provide an overview of the development of catalysts for olefin metathesis which combine high activity, durability, and excellent tolerance towards polar functional groups.
Journal ArticleDOI
Rapamycin (ay-22, 989), a new antifungal antibiotic i. taxonomy of the producing streptomycete and isolation of the active principle
TL;DR: From its characteristic ultraviolet absorption spectrum rapamycin can be classified as a triene and its activity is compared with that of amphotericin B, candicidin and nystatin.
Journal ArticleDOI
Ring-Closing Metathesis and Related Processes in Organic Synthesis
TL;DR: The transition metal alkylidene-catalyzed olefin metathesis reaction and the related transition metal-mediated carbonyl olefination reaction are two such processes as discussed by the authors.