Journal ArticleDOI
Recent Advances in the Total Synthesis of Piperidine and Pyrrolidine Natural Alkaloids with Ring‐Closing Metathesis as a Key Step
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TLDR
The most recent applications of the ring-closing metathesis reaction (RCM) to construct piperidine and pyrrolidine cores for the total synthesis of natural alkaloids are described in this paper.About:
This article is published in European Journal of Organic Chemistry.The article was published on 2003-10-01. It has received 396 citations till now. The article focuses on the topics: Ring-closing metathesis & Piperidine.read more
Citations
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Synthesis of a novel pyrrolo-[3,2-c]quinoline N-oxide by aza-Baylis–Hillman adduct of o-nitrobenzaldehyde
TL;DR: In this paper, a palladium-catalyzed reductive cyclization of an uncommon 3-ketopyrrole derivative of o -nitrobenzaldehyde, obtained in a straightforward manner through an aza-Baylis-Hillman/ring closing metathesis/aromatization reaction, was described.
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Enantiodivergent Approach to the Synthesis of Cis-2,6-Disubstituted Piperidin-4-ones.
TL;DR: The synthesis of the piperidine alkaloids (+)-241D, (-)-epimyrtine, and (-)-lasubine II demonstrated the utility of the Mannich condensation methodology.
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An efficient asymmetric desymmetrization of prochiral glutaric anhydrides with SuperQuat chiral oxazolidin-2-ones
TL;DR: In this article, the effect of substituents at the 4 and 5 positions of chiral oxazolidin-2-ones on the diastereoselectivity of the anhydride opening was studied.
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BF3·Et2O and trifluoroacetic acid/triethyl amine-mediated synthesis of functionalized piperidines
TL;DR: A two-step short and efficient strategy for the synthesis of substituted piperidones and p Piperidines in high diastereoselectivity (only trans-configuration) has been developed.
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First Total Synthesis of (+)‐Adenophorine, a Naturally Occurring Inhibitor of Glycosidases
TL;DR: The first total synthesis of a naturally occurring iminosugar, (+)-adenophorine, in 14 steps from the (+)-enantiomer ofGarner's aldehyde, is reported in this article.
References
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Synthesis and activity of a new generation of ruthenium-based olefin metathesis catalysts coordinated with 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene ligands.
TL;DR: These air- and water-tolerant complexes were shown to exhibit an increased ring-closing metathesis activity at elevated temperature when compared to that of the parent complex 2 and the previously developed complex 3.
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Recent advances in olefin metathesis and its application in organic synthesis
Robert H. Grubbs,Sukbok Chang +1 more
TL;DR: In this paper, a review of recent advances in olefin metathesis focusing on the areas of ring-closing olefi cation (RCM) and cross-metathesis is presented.
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Olefin Metathesis and Beyond
TL;DR: In this paper, the authors provide an overview of the development of catalysts for olefin metathesis which combine high activity, durability, and excellent tolerance towards polar functional groups.
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Rapamycin (ay-22, 989), a new antifungal antibiotic i. taxonomy of the producing streptomycete and isolation of the active principle
TL;DR: From its characteristic ultraviolet absorption spectrum rapamycin can be classified as a triene and its activity is compared with that of amphotericin B, candicidin and nystatin.
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Ring-Closing Metathesis and Related Processes in Organic Synthesis
TL;DR: The transition metal alkylidene-catalyzed olefin metathesis reaction and the related transition metal-mediated carbonyl olefination reaction are two such processes as discussed by the authors.