Journal ArticleDOI
Recent Advances in the Total Synthesis of Piperidine and Pyrrolidine Natural Alkaloids with Ring‐Closing Metathesis as a Key Step
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TLDR
The most recent applications of the ring-closing metathesis reaction (RCM) to construct piperidine and pyrrolidine cores for the total synthesis of natural alkaloids are described in this paper.About:
This article is published in European Journal of Organic Chemistry.The article was published on 2003-10-01. It has received 396 citations till now. The article focuses on the topics: Ring-closing metathesis & Piperidine.read more
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Metathesis Reactions in Total Synthesis
Kyriacos C. Nicolaou,Kyriacos C. Nicolaou,Paul G. Bulger,Paul G. Bulger,David Sarlah,David Sarlah +5 more
TL;DR: Examples of total syntheses in which metathesis reactions of olefins, enynes, and alkynes played a crucial role and which imparted to these endeavors certain elements of novelty, elegance, and efficiency are highlighted.
Journal ArticleDOI
Enantioselective copper-catalyzed 1,3-dipolar cycloadditions.
Levi M. Stanley,Mukund P. Sibi +1 more
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Synthesis of Pyridine and Dihydropyridine Derivatives by Regio- and Stereoselective Addition to N-Activated Pyridines
TL;DR: Stereoselective Addition to N-Activated Pyridines James A. Bull, Guillaume Pelletier,† and Andre ́ B. Charette are credited for this work.
Journal ArticleDOI
Recyclable Heterogeneous Palladium Catalysts in Pure Water: Sustainable Developments in Suzuki, Heck, Sonogashira and Tsuji–Trost Reactions
TL;DR: In this paper, a review summarizes the progress made essentially these last ten years on heterogeneous palladium catalysis in pure water and discusses the efficiency and reusability of the heterogeneous catalysts as well as the experimental conditions from a sustainable chemistry point of view.
Journal ArticleDOI
Synthesis and biological activity of pyrrole, pyrroline and pyrrolidine derivatives with two aryl groups on adjacent positions
Fabio Bellina,Renzo Rossi +1 more
TL;DR: The methods used for the synthesis of vicinal diaryl-substituted pyrrole, pyrroline and pyrrolidine derivatives are reviewed in this article, which contains 461 references and summarizes bioactivity data of some of these compounds.
References
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Asymmetric synthesis of (-)-swainsonine, (+)-1,2-di-epi-swainsonine, and (+)-1,2,8-tri-epi-swainsonine.
Karl B. Lindsay,Stephen G. Pyne +1 more
TL;DR: The asymmetric synthesis of (-)-swainsonine via a nonchiral pool route that involves the Sharpless epoxidation to induce chirality is reported.
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Asymmetric syntheses of fused bicyclic lactams.
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A new approach to (-)-swainsonine by ruthenium-catalyzed ring rearrangement
TL;DR: A new enantioselective synthesis of the idolizidine alkaloid (-)-swainsonine 1 in 40% overall yield starting from the known oxazolidinone 6 is described.
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Enantioselective allyltitanations and metathesis reactions. Application to the synthesis of piperidine alkaloids (+)-sedamine and (-)-prosophylline.
TL;DR: An enantioselective synthesis of the piperidine alkaloids (+)-sedamine and (-)-prosophylline is reported and the key steps are enantiOSElective allyltitanation reactions and ring-closing or cross-metathesis reactions.
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Synthesis mediated by ring-closing metathesis : applications in the synthesis of azasugars and alkaloids
TL;DR: The application of the ring-closing metathesis (RCM) reaction to the construction of a wide variety of nitrogen-containing ring systems is described in this article, where the examples include pyrrolizidine, indolizidine and quinoline derivatives related to azasugars.