Journal ArticleDOI
Recent Advances in the Total Synthesis of Piperidine and Pyrrolidine Natural Alkaloids with Ring‐Closing Metathesis as a Key Step
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TLDR
The most recent applications of the ring-closing metathesis reaction (RCM) to construct piperidine and pyrrolidine cores for the total synthesis of natural alkaloids are described in this paper.About:
This article is published in European Journal of Organic Chemistry.The article was published on 2003-10-01. It has received 396 citations till now. The article focuses on the topics: Ring-closing metathesis & Piperidine.read more
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Metathesis Reactions in Total Synthesis
Kyriacos C. Nicolaou,Kyriacos C. Nicolaou,Paul G. Bulger,Paul G. Bulger,David Sarlah,David Sarlah +5 more
TL;DR: Examples of total syntheses in which metathesis reactions of olefins, enynes, and alkynes played a crucial role and which imparted to these endeavors certain elements of novelty, elegance, and efficiency are highlighted.
Journal ArticleDOI
Enantioselective copper-catalyzed 1,3-dipolar cycloadditions.
Levi M. Stanley,Mukund P. Sibi +1 more
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Synthesis of Pyridine and Dihydropyridine Derivatives by Regio- and Stereoselective Addition to N-Activated Pyridines
TL;DR: Stereoselective Addition to N-Activated Pyridines James A. Bull, Guillaume Pelletier,† and Andre ́ B. Charette are credited for this work.
Journal ArticleDOI
Recyclable Heterogeneous Palladium Catalysts in Pure Water: Sustainable Developments in Suzuki, Heck, Sonogashira and Tsuji–Trost Reactions
TL;DR: In this paper, a review summarizes the progress made essentially these last ten years on heterogeneous palladium catalysis in pure water and discusses the efficiency and reusability of the heterogeneous catalysts as well as the experimental conditions from a sustainable chemistry point of view.
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Synthesis and biological activity of pyrrole, pyrroline and pyrrolidine derivatives with two aryl groups on adjacent positions
Fabio Bellina,Renzo Rossi +1 more
TL;DR: The methods used for the synthesis of vicinal diaryl-substituted pyrrole, pyrroline and pyrrolidine derivatives are reviewed in this article, which contains 461 references and summarizes bioactivity data of some of these compounds.
References
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An imine addition/ring-closing metathesis approach to the spirocyclic core of halichlorine and pinnaic acid.
TL;DR: A newly reported metathesis catalyst was show to be highly effective for cyclization of halichlorine and pinnaic acid model systems.
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Efficient enantiomeric synthesis of pyrrolidine and piperidine alkaloids from tobacco.
François-Xavier Felpin,Sandrine Girard,Giang Vo-Thanh,Richard J. Robins,Jean Villieras,Jacques Lebreton +5 more
TL;DR: An enantiomeric synthesis of six piperidine and pyrrolidine alkaloids, known as natural products in tobacco, was established from a common chiral homoallylic (S)-3-(1-azido-but-3-enyl)-pyridine 15.
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Nitrogen heterocycles from furans : the aza-achmatowicz reaction
Marco A. Ciufolini,Cynthia Y. W. Hermann,Qing Dong,Toshio Shimizu,Shankar Swaminathan,Ning Xi +5 more
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Ring-closing olefin metathesis for the synthesis of fused nitrogen heterocycles
Stephen F. Martin,Hui Ju Chen,Anne K. Courtney,Yusheng Liao,Michael Pätzel,Melissa N. Ramser,Allan S. Wagman +6 more
TL;DR: In this article, a ring-closing metathesis (RCM) was used to synthesize fused nitrogen heterocycles with various combinations of five-and eight-membered rings.
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Enantioselective Synthesis of Tetraponerines by Pd- and Ru-Catalyzed Domino Reactions
TL;DR: In this article, an enantioselective synthesis of tetraponerines T4, T6, T7, and T8 in 24−36% overall yield is described.