Journal ArticleDOI
Recent Advances in the Total Synthesis of Piperidine and Pyrrolidine Natural Alkaloids with Ring‐Closing Metathesis as a Key Step
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TLDR
The most recent applications of the ring-closing metathesis reaction (RCM) to construct piperidine and pyrrolidine cores for the total synthesis of natural alkaloids are described in this paper.About:
This article is published in European Journal of Organic Chemistry.The article was published on 2003-10-01. It has received 396 citations till now. The article focuses on the topics: Ring-closing metathesis & Piperidine.read more
Citations
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Synthesis of pharmaceutically active compounds containing a disubstituted piperidine framework.
Sara Källström,Reko Leino +1 more
TL;DR: The synthesis of pharmaceutically active compounds bearing a disubstituted piperidine framework is reviewed and the activity and/or usage of the same is briefly covered.
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Enantioselective bromoaminocyclization using amino-thiocarbamate catalysts.
TL;DR: A facile and efficient enantioselective bromoaminocyclization of unsaturated sulfonamides has been developed using an amino-thiocarbamate catalyst and a range of enantioenriched pyrrolidines were prepared.
Journal ArticleDOI
Organocatalytic Asymmetric Three‐Component Cyclization of Cinnamaldehydes and Primary Amines with 1,3‐Dicarbonyl Compounds: Straightforward Access to Enantiomerically Enriched Dihydropyridines
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Iron-catalyzed direct alkenylation of 2-substituted azaarenes with N-sulfonyl aldimines via C-H bond activation.
TL;DR: A novel iron-catalyzed alkenylation of 2-substituted azaarenes through sp(3) C-H bond activation has been developed and represents an efficient way to synthesize 2-alkenylated azaarnes from simple starting materials.
Journal ArticleDOI
Recent Developments in the Synthesis of Pyrrolidine‐Containing Iminosugars
Bridget L. Stocker,Emma M. Dangerfield,Emma M. Dangerfield,Anna L. Win-Mason,Anna L. Win-Mason,Gregory W. Haslett,Gregory W. Haslett,Mattie S. M. Timmer +7 more
TL;DR: In this paper, a microreview highlights recent developments in the synthesis of pyrrolidine-containing iminosugars and includes discussions of methodologies such as ring-closing metathesis, aldol and pericyclic reactions, and protecting-group free strategies.
References
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Synthesis and activity of a new generation of ruthenium-based olefin metathesis catalysts coordinated with 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene ligands.
TL;DR: These air- and water-tolerant complexes were shown to exhibit an increased ring-closing metathesis activity at elevated temperature when compared to that of the parent complex 2 and the previously developed complex 3.
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Recent advances in olefin metathesis and its application in organic synthesis
Robert H. Grubbs,Sukbok Chang +1 more
TL;DR: In this paper, a review of recent advances in olefin metathesis focusing on the areas of ring-closing olefi cation (RCM) and cross-metathesis is presented.
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Olefin Metathesis and Beyond
TL;DR: In this paper, the authors provide an overview of the development of catalysts for olefin metathesis which combine high activity, durability, and excellent tolerance towards polar functional groups.
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Rapamycin (ay-22, 989), a new antifungal antibiotic i. taxonomy of the producing streptomycete and isolation of the active principle
TL;DR: From its characteristic ultraviolet absorption spectrum rapamycin can be classified as a triene and its activity is compared with that of amphotericin B, candicidin and nystatin.
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Ring-Closing Metathesis and Related Processes in Organic Synthesis
TL;DR: The transition metal alkylidene-catalyzed olefin metathesis reaction and the related transition metal-mediated carbonyl olefination reaction are two such processes as discussed by the authors.