Journal ArticleDOI
Recent Advances in the Total Synthesis of Piperidine and Pyrrolidine Natural Alkaloids with Ring‐Closing Metathesis as a Key Step
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TLDR
The most recent applications of the ring-closing metathesis reaction (RCM) to construct piperidine and pyrrolidine cores for the total synthesis of natural alkaloids are described in this paper.About:
This article is published in European Journal of Organic Chemistry.The article was published on 2003-10-01. It has received 396 citations till now. The article focuses on the topics: Ring-closing metathesis & Piperidine.read more
Citations
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Book ChapterDOI
Synthesis of Piperidines and Dehydropiperidines: Construction of the Six-Membered Ring
Marco M. Nebe,Till Opatz +1 more
TL;DR: A review of strategies for the construction of piperidine and dehydropiperidines can be found in this paper, where the authors focus on the topology of the bond forming events generating the piperidine core.
Journal ArticleDOI
Stereoselective synthesis of N-heterocycles: application of the asymmetric Cu-catalyzed addition of Et2Zn to functionalized alkyl and aryl imines
TL;DR: In this paper, a copper-catalyzed addition of diethylzinc to functionalized alkyl-substituted imines that were generated in situ from the sulfinic acid adducts was described.
Journal ArticleDOI
Reactivity of pyridines bearing EWG with bis-(TMS)ketene acetals. Substituent-induced lactonization reaction
Alejandro Rivera‐Hernandez,Guillermo M. Chans,Henri Rudler,José Cortés,R. Alfredo Toscano,Cecilio Alvarez-Toledano +5 more
TL;DR: In this article, the scope, limitations, and regioselectivity of these reactions were studied, confirming the utility of bis-(TMS)ketene acetals as 1,3-dinucleophiles in this type of reactions, extending thus the range of synthesis of aza-compounds.
Journal ArticleDOI
Synthesis of psudoheliotridane via formal [3+2] annulation and ring-closing metathesis
TL;DR: In this article, the pyrrolizidine skeleton was obtained via the ring-closing metathesis (RCM) method, which was used to synthesize psudoheliotridane.
Journal ArticleDOI
N-O tethered carbenoid cyclopropanation facilitates the synthesis of a functionalized cyclopropyl-fused pyrrolidine.
TL;DR: A facile approach to a cyclopropyl-fused pyrrolidine, which contains four stereogenic centers, is reported by employing the N-O tethered carbenoid methodology, demonstrating the potential of this methodology for making cycloprostyl- fused heterocycles.
References
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Journal ArticleDOI
Synthesis and activity of a new generation of ruthenium-based olefin metathesis catalysts coordinated with 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene ligands.
TL;DR: These air- and water-tolerant complexes were shown to exhibit an increased ring-closing metathesis activity at elevated temperature when compared to that of the parent complex 2 and the previously developed complex 3.
Journal ArticleDOI
Recent advances in olefin metathesis and its application in organic synthesis
Robert H. Grubbs,Sukbok Chang +1 more
TL;DR: In this paper, a review of recent advances in olefin metathesis focusing on the areas of ring-closing olefi cation (RCM) and cross-metathesis is presented.
Journal ArticleDOI
Olefin Metathesis and Beyond
TL;DR: In this paper, the authors provide an overview of the development of catalysts for olefin metathesis which combine high activity, durability, and excellent tolerance towards polar functional groups.
Journal ArticleDOI
Rapamycin (ay-22, 989), a new antifungal antibiotic i. taxonomy of the producing streptomycete and isolation of the active principle
TL;DR: From its characteristic ultraviolet absorption spectrum rapamycin can be classified as a triene and its activity is compared with that of amphotericin B, candicidin and nystatin.
Journal ArticleDOI
Ring-Closing Metathesis and Related Processes in Organic Synthesis
TL;DR: The transition metal alkylidene-catalyzed olefin metathesis reaction and the related transition metal-mediated carbonyl olefination reaction are two such processes as discussed by the authors.