Journal ArticleDOI
Recent developments in buccal and sublingual delivery systems.
TLDR
It is envisaged that in the future, buccal and sublingual delivery technologies will provide a platform for the successful delivery of vaccines and antigens, and it is foreseen that physical means of enhancing drug uptake will be commercialized for buCCal delivery, thereby expanding the current drug candidate list for this area.Abstract:
Introduction: There have been several advances in the delivery of drugs through the buccal mucosa over the last 5 years, which have resulted in a number of new buccal delivery products appearing on the market. Areas covered: This review discusses the most recent developments in the area of buccal and sublingual drug delivery, with a focus on marketed drugs. Likely future directions are also considered and reported. Expert opinion: The future potential of buccal and sublingual delivery systems looks favorable. It is envisaged that in the future, buccal and sublingual delivery technologies will provide a platform for the successful delivery of vaccines and antigens. It is also foreseen that physical means of enhancing drug uptake (e.g., sonophoresis, iontophoresis and electroporation) will be commercialized for buccal delivery, thereby expanding the current drug candidate list for this area. The formulation of delivery systems for photosensitizers in photodynamic therapy is a potential emerging area, while ...read more
Citations
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Journal ArticleDOI
Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies
TL;DR: Recent advances in formulation and delivery strategies, such as the use of microsphere-based controlled-release technologies, protein modification methods that make use of polyethylene glycol and other polymers, and genetic manipulation of biopharmaceutical drugs are highlighted and discussed.
BookDOI
Handbook of Encapsulation and Controlled Release
TL;DR: The Handbook of Encapsulation and Controlled Release as discussed by the authors covers the entire field, presenting the fundamental processes involved and exploring how to use those processes for different applications in industry, including microencapsulation.
Journal ArticleDOI
Enhancing the buccal mucosal delivery of peptide and protein therapeutics.
TL;DR: This review provides an update on recent approaches that have shown promise in enhancing the buccal mucosal transport of macromolecules, with a major focus on proteins and peptides.
Journal ArticleDOI
Oral transmucosal drug delivery for pediatric use.
TL;DR: This article aims to provide a comprehensive review of the current development of oral transmucosal delivery specifically for the pediatric population in order to achieve systemic drug delivery.
Journal ArticleDOI
Challenges and Future Prospects for the Delivery of Biologics: Oral Mucosal, Pulmonary, and Transdermal Routes.
Javier O. Morales,Kristin Fathe,Ashlee D. Brunaugh,Siilvia Ferrati,Song Li,Miguel Montenegro-Nicolini,Zeynab Mousavikhamene,Jason T. McConville,Mark R. Prausnitz,Hugh D. C. Smyth +9 more
TL;DR: The buccal, sublingual, pulmonary, and transdermal routes of administration for biologics with relevant details of the respective barriers are described and critical views in future developments of each route are given.
References
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Journal ArticleDOI
Mucosal immunity and vaccines
Jan Holmgren,Cecil Czerkinsky +1 more
TL;DR: The properties of the mucosal immune system are reviewed and advances in the development of mucosal vaccines for protection against infections and for treatment of various inflammatory disorders are discussed.
Journal ArticleDOI
Photodynamic antimicrobial chemotherapy (PACT).
TL;DR: Photodynamic antimicrobial chemotherapy (PACT), which predates the related cancer regimen, is proposed as a potential, low-cost approach to the treatment of locally occurring infection.
Journal ArticleDOI
Photodynamic Therapy in Dentistry
TL;DR: Applications of PDT in dentistry are growing rapidly: the treatment of oral cancer, bacterial and fungal infection therapies, and the photodynamic diagnosis (PDD) of the malignant transformation of oral lesions, which represents a novel therapeutic approach in the management of oral biofilms.
Journal ArticleDOI
Mucoadhesive polymeric platforms for controlled drug delivery
TL;DR: The success and degree of muco-adhesive bonding is influenced by various polymer-based properties such as the degree of cross-linking, chain length and the presence of various functional groupings as mentioned in this paper.
Journal ArticleDOI
New horizons in adjuvants for vaccine development
TL;DR: The current state of adjuvant research and development and how formulation parameters can influence the effectiveness of adjuvants are outlined.