Recurrence and Survival After Random Assignment to Laparoscopy Versus Laparotomy for Comprehensive Surgical Staging of Uterine Cancer: Gynecologic Oncology Group LAP2 Study
Joan L. Walker,Marion Piedmonte,Nick M. Spirtos,Scott M. Eisenkop,John B. Schlaerth,Robert S. Mannel,Richard R. Barakat,Michael L. Pearl,Sudarshan K. Sharma +8 more
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The potential for increased risk of cancer recurrence with laparoscopy versus laparotomy was quantified and found to be small, providing accurate information for decision making for women with uterine cancer.Abstract:
Purpose The primary objective was to establish noninferiority of laparoscopy compared with laparotomy for recurrence after surgical staging of uterine cancer. Patients and Methods Patients with clinical stages I to IIA disease were randomly allocated (two to one) to laparoscopy (n = 1,696) versus laparotomy (n = 920) for hysterectomy, salpingo-oophorectomy, pelvic cytology, and pelvic and para-aortic lymphadenectomy. The primary study end point was noninferiority of recurrence-free interval defined as no more than a 40% increase in the risk of recurrence with laparoscopy compared with laparotomy. Results With a median follow-up time of 59 months for 2,181 patients still alive, there were 309 recurrences (210 laparoscopy; 99 laparotomy) and 350 deaths (229 laparoscopy; 121 laparotomy). The estimated hazard ratio for laparoscopy relative to laparotomy was 1.14 (90% lower bound, 0.92; 95% upper bound, 1.46), falling short of the protocol-specified definition of noninferiority. However, the actual recurrence ...read more
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Clinical practice guidelines in oncology
William J. Gradishar,Benjamin O. Anderson,Ron Balassanian,Sarah L. Blair,Harold J. Burstein,Amy E. Cyr,Anthony D. Elias,William B. Farrar,Andres Forero,Sharon H. Giordano,Matthew P. Goetz,Lori J. Goldstein,Steven J. Isakoff,Janice A. Lyons,P. Kelly Marcom,Ingrid A. Mayer,Beryl McCormick,Meena S. Moran,Ruth O'Regan,Sameer A. Patel,Lori J. Pierce,Elizabeth C. Reed,Kilian E. Salerno,Lee S. Schwartzberg,Amy Sitapati,Karen L. Smith,Mary Lou Smith,Hatem Soliman,George Somlo,Melinda L. Telli,John H. Ward,Rashmi Kumar,Dorothy A. Shead +32 more
TL;DR: This manuscript focuses on the NCCN Guidelines Panel recommendations for the workup, primary treatment, risk reduction strategies, and surveillance specific to DCIS.
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ESMO-ESGO-ESTRO Consensus Conference on Endometrial Cancer: diagnosis, treatment and follow-up
Nicoletta Colombo,Carien L. Creutzberg,Frédéric Amant,Tjalling Bosse,Antonio González-Martín,Jonathan A. Ledermann,Christian Marth,Remi A. Nout,Denis Querleu,Mansoor Raza Mirza,Cristiana Sessa +10 more
TL;DR: The first joint European Society for Medical Oncology (ESMO), European SocieTy for Radiotherapy & Oncologies (ESTRO), and European Society of Gynaecological Oncologists (ESGO) consensus conference on endometrial cancer was held on 11-13 December 2014 in Milan, Italy, and comprised a multidisciplinary panel of 40 leading experts in the management of endometrium cancer as discussed by the authors.
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Nicole Concin,Xavier Matias-Guiu,Ignace Vergote,David Cibula,Mansoor Raza Mirza,Simone Marnitz,Jonathan A. Ledermann,Tjalling Bosse,Cyrus Chargari,Anna Fagotti,Christina Fotopoulou,Antonio Gonzalez Martin,Sigurd Lax,Domenica Lorusso,Christian Marth,Philippe Morice,Remi A. Nout,Dearbhaile M. O'Donnell,Denis Querleu,Maria Rosaria Raspollini,Jalid Sehouli,Alina Sturdza,Alexandra Taylor,Anneke M. Westermann,Pauline Wimberger,Nicoletta Colombo,François Planchamp,Carien L. Creutzberg +27 more
TL;DR: A European consensus conference on endometrial carcinoma was held in 2014 to produce multi-disciplinary evidence-based guidelines on selected questions as mentioned in this paper, and the European Society of Gynaecological Oncology (ESGO), the European SocieTy for Radiotherapy and Oncologies (ESTRO), and the EPSP jointly decided to update these evidence-base guidelines and to cover new topics in order to improve the quality of care for women with endometrium carcinoma across Europe and worldwide.
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ESMO-ESGO-ESTRO Consensus Conference on Endometrial Cancer: Diagnosis, Treatment and Follow-up.
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TL;DR: In an epidemiologic study, minimally invasive radical hysterectomy was associated with shorter overall survival than open surgery among women with stage IA2 or IB1 cervical carcinoma.
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