Journal ArticleDOI
Recurrent inhibitory circuitry as a mechanism for grid formation
Jonathan J. Couey,Aree Witoelar,Sheng-Jia Zhang,Kang Zheng,Jing Ye,Benjamin Dunn,Rafal Czajkowski,May-Britt Moser,Edvard I. Moser,Yasser Roudi,Menno P. Witter +10 more
TLDR
It is demonstrated that stellate cells, the principal cell type in the layer II grid network, are mainly interconnected via inhibitory interneurons, and that stable grid firing can emerge from a simple recurrent inhibitory network.Abstract:
Grid cells in layer II of the medial entorhinal cortex form a principal component of the mammalian neural representation of space. The firing pattern of a single grid cell has been hypothesized to be generated through attractor dynamics in a network with a specific local connectivity including both excitatory and inhibitory connections. However, experimental evidence supporting the presence of such connectivity among grid cells in layer II is limited. Here we report recordings from more than 600 neuron pairs in rat entorhinal slices, demonstrating that stellate cells, the principal cell type in the layer II grid network, are mainly interconnected via inhibitory interneurons. Using a model attractor network, we demonstrate that stable grid firing can emerge from a simple recurrent inhibitory network. Our findings thus suggest that the observed inhibitory microcircuitry between stellate cells is sufficient to generate grid-cell firing patterns in layer II of the medial entorhinal cortex.read more
Citations
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Journal ArticleDOI
Grid cells require excitatory drive from the hippocampus
Tora Bonnevie,Benjamin Dunn,Marianne Fyhn,Marianne Fyhn,Torkel Hafting,Torkel Hafting,Dori Derdikman,Dori Derdikman,John L. Kubie,Yasser Roudi,Edvard I. Moser,May-Britt Moser +11 more
TL;DR: The results point to excitatory drive from the hippocampus, and possibly other regions, as one prerequisite for the formation and translocation of grid patterns in the MEC.
Journal ArticleDOI
Grid cells and cortical representation
Edvard I. Moser,Yasser Roudi,Menno P. Witter,Clifford Kentros,Tobias Bonhoeffer,May-Britt Moser +5 more
TL;DR: This Review uses grid cells in the medial entorhinal cortex as a gateway to understand network computation at a stage of cortical processing in which firing patterns are shaped not primarily by incoming sensory signals but to a large extent by the intrinsic properties of the local circuit.
Journal ArticleDOI
Island cells control temporal association memory
Takashi Kitamura,Michele Pignatelli,Junghyup Suh,Keigo Kohara,Atsushi Yoshiki,Kuniya Abe,Susumu Tonegawa,Susumu Tonegawa +7 more
TL;DR: Clusters of excitatory neurons called island cells, which appear in a curvilinear matrix of bulblike structures, directly project to CA1, and activate interneurons that target the distal dendrites of CA1 pyramidal neurons, compose a control circuit for temporal association memory.
Journal ArticleDOI
Cellular mechanisms of spatial navigation in the medial entorhinal cortex.
TL;DR: It is found that the membrane potential signature of stellate cells during firing field crossings consisted of a slow depolarization driving spike output, which is best predicted by network models in which neurons receive sustained depolarizing synaptic input during a field crossing, such as continuous attractor network models of grid cell firing.
Journal ArticleDOI
Optogenetic Dissection of Entorhinal-Hippocampal Functional Connectivity
Sheng-Jia Zhang,Jing Ye,Chenglin Miao,Albert Tsao,Ignas Cerniauskas,Debora Ledergerber,May-Britt Moser,Edvard I. Moser +7 more
TL;DR: These findings suggest that place signals are generated by convergence of signals from a variety of entorhinal functional cell types, of which grid cells are the most abundant spatial cell type.
References
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The Rat Brain in Stereotaxic Coordinates
George Paxinos,Charles Watson +1 more
TL;DR: This paper presents a meta-analyses of the determinants of earthquake-triggered landsliding in the Czech Republic over a period of 18 months in order to establish a probabilistic framework for estimating the intensity of the earthquake.
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Nathan C. Shaner,Robert E. Campbell,Robert E. Campbell,Paul Steinbach,Ben N G Giepmans,Amy E. Palmer,Roger Y. Tsien +6 more
TL;DR: The latest red version matures more completely, is more tolerant of N-terminal fusions and is over tenfold more photostable than mRFP1, and three monomers with distinguishable hues from yellow-orange to red-orange have higher quantum efficiencies.
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Millisecond-timescale, genetically targeted optical control of neural activity.
TL;DR: In this paper, the authors adapted the naturally occurring algal protein Channelrhodopsin-2, a rapidly gated light-sensitive cation channel, by using lentiviral gene delivery in combination with high-speed optical switching to photostimulate mammalian neurons.
Journal ArticleDOI
Microstructure of a spatial map in the entorhinal cortex
TL;DR: The dorsocaudal medial entorhinal cortex (dMEC) contains a directionally oriented, topographically organized neural map of the spatial environment, whose key unit is the ‘grid cell’, which is activated whenever the animal's position coincides with any vertex of a regular grid of equilateral triangles spanning the surface of the environment.
Journal ArticleDOI
Dynamics of pattern formation in lateral-inhibition type neural fields
TL;DR: The dynamics of pattern formation is studied for lateral-inhibition type homogeneous neural fields with general connections and it is proved that there are five types of pattern dynamics.