Journal ArticleDOI
Recurrent inhibitory circuitry as a mechanism for grid formation
Jonathan J. Couey,Aree Witoelar,Sheng-Jia Zhang,Kang Zheng,Jing Ye,Benjamin Dunn,Rafal Czajkowski,May-Britt Moser,Edvard I. Moser,Yasser Roudi,Menno P. Witter +10 more
TLDR
It is demonstrated that stellate cells, the principal cell type in the layer II grid network, are mainly interconnected via inhibitory interneurons, and that stable grid firing can emerge from a simple recurrent inhibitory network.Abstract:
Grid cells in layer II of the medial entorhinal cortex form a principal component of the mammalian neural representation of space. The firing pattern of a single grid cell has been hypothesized to be generated through attractor dynamics in a network with a specific local connectivity including both excitatory and inhibitory connections. However, experimental evidence supporting the presence of such connectivity among grid cells in layer II is limited. Here we report recordings from more than 600 neuron pairs in rat entorhinal slices, demonstrating that stellate cells, the principal cell type in the layer II grid network, are mainly interconnected via inhibitory interneurons. Using a model attractor network, we demonstrate that stable grid firing can emerge from a simple recurrent inhibitory network. Our findings thus suggest that the observed inhibitory microcircuitry between stellate cells is sufficient to generate grid-cell firing patterns in layer II of the medial entorhinal cortex.read more
Citations
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Journal ArticleDOI
Extrinsic control and intrinsic computation in the hippocampal CA1 circuit
TL;DR: In this article , a combination of optogenetic and pharmacogenetic local and upstream inactivation was performed in the hippocampus to understand the extent to which neuronal spiking reflects local computation or responses to upstream inputs.
Posted ContentDOI
Grid cells show field-to-field variability and this explains the aperiodic response of inhibitory interneurons
TL;DR: In this paper, a two-population excitatory-inhibitory network model was proposed to predict the firing rate of neurons in the hippocampus of a rat during free navigation.
Journal ArticleDOI
Activity Dynamics and Signal Representation in a Striatal Network Model with Distance-Dependent Connectivity
TL;DR: It is proposed that in a healthy state the striatum operates in a AI/TA state and that lack of dopamine pushes it into a WTA state, as in “winner-take-all” (WTA) dynamics.
Journal ArticleDOI
Anatomical and Electrophysiological Clustering of Superficial Medial Entorhinal Cortex Interneurons.
TL;DR: K-means clustering of interneuron anatomical and electrophysiological data optimally classified a population of 106 interneurons into four distinct clusters, which will provide greater understanding of the electrophYSiological characteristics of MEC interneeurons, help guide future in vivo studies, and may aid in uncovering the mechanism of grid field formation.
Journal ArticleDOI
Distinct gamma oscillations in the distal dendritic fields of the dentate gyrus and the CA1 area of mouse hippocampus.
TL;DR: A set of gamma oscillations that differentially regulate neuronal activity in the dentate gyrus and CA1 area, and may allow flexible segregation and integration of information across different levels of hippocampal circuitry are disclosed.
References
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TL;DR: This paper presents a meta-analyses of the determinants of earthquake-triggered landsliding in the Czech Republic over a period of 18 months in order to establish a probabilistic framework for estimating the intensity of the earthquake.
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Millisecond-timescale, genetically targeted optical control of neural activity.
TL;DR: In this paper, the authors adapted the naturally occurring algal protein Channelrhodopsin-2, a rapidly gated light-sensitive cation channel, by using lentiviral gene delivery in combination with high-speed optical switching to photostimulate mammalian neurons.
Journal ArticleDOI
Microstructure of a spatial map in the entorhinal cortex
TL;DR: The dorsocaudal medial entorhinal cortex (dMEC) contains a directionally oriented, topographically organized neural map of the spatial environment, whose key unit is the ‘grid cell’, which is activated whenever the animal's position coincides with any vertex of a regular grid of equilateral triangles spanning the surface of the environment.
Journal ArticleDOI
Dynamics of pattern formation in lateral-inhibition type neural fields
TL;DR: The dynamics of pattern formation is studied for lateral-inhibition type homogeneous neural fields with general connections and it is proved that there are five types of pattern dynamics.