Journal ArticleDOI
Recurrent inhibitory circuitry as a mechanism for grid formation
Jonathan J. Couey,Aree Witoelar,Sheng-Jia Zhang,Kang Zheng,Jing Ye,Benjamin Dunn,Rafal Czajkowski,May-Britt Moser,Edvard I. Moser,Yasser Roudi,Menno P. Witter +10 more
TLDR
It is demonstrated that stellate cells, the principal cell type in the layer II grid network, are mainly interconnected via inhibitory interneurons, and that stable grid firing can emerge from a simple recurrent inhibitory network.Abstract:
Grid cells in layer II of the medial entorhinal cortex form a principal component of the mammalian neural representation of space. The firing pattern of a single grid cell has been hypothesized to be generated through attractor dynamics in a network with a specific local connectivity including both excitatory and inhibitory connections. However, experimental evidence supporting the presence of such connectivity among grid cells in layer II is limited. Here we report recordings from more than 600 neuron pairs in rat entorhinal slices, demonstrating that stellate cells, the principal cell type in the layer II grid network, are mainly interconnected via inhibitory interneurons. Using a model attractor network, we demonstrate that stable grid firing can emerge from a simple recurrent inhibitory network. Our findings thus suggest that the observed inhibitory microcircuitry between stellate cells is sufficient to generate grid-cell firing patterns in layer II of the medial entorhinal cortex.read more
Citations
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From smooth cortical gradients to discrete modules: A 1 biologically plausible mechanism for the self-organization of 2 modularity in grid cells
TL;DR: This work reveals novel self-organization mechanisms by which simple local interactions and smooth gradients may interact to produce macroscopic modular organization in the grid cell system.
Journal ArticleDOI
An entorhinal-like region in food-caching birds
TL;DR: In this article , the authors mapped extrinsic hippocampal connections in chickadees and found a well-delineated structure in these birds that is topologically similar to the entorhinal cortex and interfaces between the hippocampus and other pallial regions.
Posted ContentDOI
Experience replay facilitates the formation of the hexagonal pattern of grid cells
TL;DR: In this paper , the authors used the continuous attractor model to simulate the formation of the hexagonal pattern of entorhinal grid cells, the metric for cognitive map, during the experience replay of hippocampal place cell.
Posted ContentDOI
Ketamine evoked disruption of entorhinal and hippocampal spatial maps
TL;DR: In this paper , the authors used electrophysiology and calcium imaging to examine ketamine's impacts on the medial entorhinal cortex and hippocampus, which contain neurons that encode an animal's spatial position, as mice navigated virtual reality and real world environments.
Grid Cell Network Decoding For Robot Localisation
TL;DR: The outcomes of the experiments show that the decoder, in principle, can be trained and used to successfully retrace the path of a simulated robot and demonstrate that precise location estimates can be decoded from such a system.
References
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Journal ArticleDOI
Microstructure of a spatial map in the entorhinal cortex
TL;DR: The dorsocaudal medial entorhinal cortex (dMEC) contains a directionally oriented, topographically organized neural map of the spatial environment, whose key unit is the ‘grid cell’, which is activated whenever the animal's position coincides with any vertex of a regular grid of equilateral triangles spanning the surface of the environment.
Journal ArticleDOI
Dynamics of pattern formation in lateral-inhibition type neural fields
TL;DR: The dynamics of pattern formation is studied for lateral-inhibition type homogeneous neural fields with general connections and it is proved that there are five types of pattern dynamics.