Journal ArticleDOI
Recurrent inhibitory circuitry as a mechanism for grid formation
Jonathan J. Couey,Aree Witoelar,Sheng-Jia Zhang,Kang Zheng,Jing Ye,Benjamin Dunn,Rafal Czajkowski,May-Britt Moser,Edvard I. Moser,Yasser Roudi,Menno P. Witter +10 more
TLDR
It is demonstrated that stellate cells, the principal cell type in the layer II grid network, are mainly interconnected via inhibitory interneurons, and that stable grid firing can emerge from a simple recurrent inhibitory network.Abstract:
Grid cells in layer II of the medial entorhinal cortex form a principal component of the mammalian neural representation of space. The firing pattern of a single grid cell has been hypothesized to be generated through attractor dynamics in a network with a specific local connectivity including both excitatory and inhibitory connections. However, experimental evidence supporting the presence of such connectivity among grid cells in layer II is limited. Here we report recordings from more than 600 neuron pairs in rat entorhinal slices, demonstrating that stellate cells, the principal cell type in the layer II grid network, are mainly interconnected via inhibitory interneurons. Using a model attractor network, we demonstrate that stable grid firing can emerge from a simple recurrent inhibitory network. Our findings thus suggest that the observed inhibitory microcircuitry between stellate cells is sufficient to generate grid-cell firing patterns in layer II of the medial entorhinal cortex.read more
Citations
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Posted Content
Neurodegenerative damage reduces firing coherence in a continuous attractor model of grid cells
Yuduo Zhi,Daniel N. Cox +1 more
TL;DR: Within an established two-dimensional continuous attractor neural network model of grid cell activity, neural sheet damage is introduced by radius and by the strength of the synaptic output for neurons in the damaged region to establish coherent grid firing fields for individual grid cells for a roaming animal.
Proceedings Article
Explaining heterogeneity in medial entorhinal cortex with task-driven neural networks
Aran Nayebi,Alexander Attinger,Malcolm G. Campbell,Kiah Hardcastle,Isabel I. C. Low,Caitlin S. Mallory,Gabriel Mel,Ben Sorscher,Alex H. Williams,Surya Ganguli,Lisa M. Giocomo,Daniel L. K. Yamins +11 more
Posted ContentDOI
Modeling grid fields instead of modeling grid cells
TL;DR: It is shown that the organization and evolution of grid fields relate very simply to physical space, and the relationship between the ‘macroscopic’ model for grid fields and existing ‘microscopic' models of grid cell activity is drawn.
Book ChapterDOI
A Model for Grid Firing and Theta-Nested Gamma Oscillations in Layer 2 of the Medial Entorhinal Cortex
TL;DR: The model demonstrates that indirect interactions between L2SCs mediated via inhibitory neurons are sufficient for emergence of grid firing and nested game oscillations.
Journal ArticleDOI
Spatially structured inhibition defined by polarized parvalbumin interneuron axons promotes head direction tuning
Yangfan Peng,Federico J. Barreda Tomas,Paul Pfeiffer,Moritz Drangmeister,Susanne Schreiber,Imre Vida,Jörg R.P. Geiger +6 more
TL;DR: In the rat superficial presubiculum, this article found that inhibition by fast-spiking interneurons is organized in the form of a dominant super-reciprocal microcircuit motif where multiple pyramidal cells recurrently inhibit each other via a single interneuron.
References
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Book
The Rat Brain in Stereotaxic Coordinates
George Paxinos,Charles Watson +1 more
TL;DR: This paper presents a meta-analyses of the determinants of earthquake-triggered landsliding in the Czech Republic over a period of 18 months in order to establish a probabilistic framework for estimating the intensity of the earthquake.
Journal ArticleDOI
Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein.
Nathan C. Shaner,Robert E. Campbell,Robert E. Campbell,Paul Steinbach,Ben N G Giepmans,Amy E. Palmer,Roger Y. Tsien +6 more
TL;DR: The latest red version matures more completely, is more tolerant of N-terminal fusions and is over tenfold more photostable than mRFP1, and three monomers with distinguishable hues from yellow-orange to red-orange have higher quantum efficiencies.
Journal ArticleDOI
Millisecond-timescale, genetically targeted optical control of neural activity.
TL;DR: In this paper, the authors adapted the naturally occurring algal protein Channelrhodopsin-2, a rapidly gated light-sensitive cation channel, by using lentiviral gene delivery in combination with high-speed optical switching to photostimulate mammalian neurons.
Journal ArticleDOI
Microstructure of a spatial map in the entorhinal cortex
TL;DR: The dorsocaudal medial entorhinal cortex (dMEC) contains a directionally oriented, topographically organized neural map of the spatial environment, whose key unit is the ‘grid cell’, which is activated whenever the animal's position coincides with any vertex of a regular grid of equilateral triangles spanning the surface of the environment.
Journal ArticleDOI
Dynamics of pattern formation in lateral-inhibition type neural fields
TL;DR: The dynamics of pattern formation is studied for lateral-inhibition type homogeneous neural fields with general connections and it is proved that there are five types of pattern dynamics.