Journal ArticleDOI
Recurrent inhibitory circuitry as a mechanism for grid formation
Jonathan J. Couey,Aree Witoelar,Sheng-Jia Zhang,Kang Zheng,Jing Ye,Benjamin Dunn,Rafal Czajkowski,May-Britt Moser,Edvard I. Moser,Yasser Roudi,Menno P. Witter +10 more
TLDR
It is demonstrated that stellate cells, the principal cell type in the layer II grid network, are mainly interconnected via inhibitory interneurons, and that stable grid firing can emerge from a simple recurrent inhibitory network.Abstract:
Grid cells in layer II of the medial entorhinal cortex form a principal component of the mammalian neural representation of space. The firing pattern of a single grid cell has been hypothesized to be generated through attractor dynamics in a network with a specific local connectivity including both excitatory and inhibitory connections. However, experimental evidence supporting the presence of such connectivity among grid cells in layer II is limited. Here we report recordings from more than 600 neuron pairs in rat entorhinal slices, demonstrating that stellate cells, the principal cell type in the layer II grid network, are mainly interconnected via inhibitory interneurons. Using a model attractor network, we demonstrate that stable grid firing can emerge from a simple recurrent inhibitory network. Our findings thus suggest that the observed inhibitory microcircuitry between stellate cells is sufficient to generate grid-cell firing patterns in layer II of the medial entorhinal cortex.read more
Citations
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Journal ArticleDOI
Specific evidence of low-dimensional continuous attractor dynamics in grid cells
TL;DR: Results from novel environments suggest cell-cell structure is not inherited from hippocampal or external sensory inputs and substantiate the general hypothesis that the brain computes using low-dimensional continuous attractors.
Journal ArticleDOI
Architecture of the Entorhinal Cortex A Review of Entorhinal Anatomy in Rodents with Some Comparative Notes.
TL;DR: It is argued that subdividing EC into two components, the lateral EC (LEC) and medial EC (MEC) might suffice to describe the functional architecture of EC, and a reappraisal of the notion of EC as a layered input-output structure for the hippocampal formation is suggested.
Conjunctive Representation of Position, Direction, and Velocity in Entorhinal Cortex
B. Carrier,Robert K. Hofbauer,M. C. Bushnell,G. H. Duncan,Samuel M. McClure,D. I. Laibson,George Loewenstein,Jonathan D. Cohen +7 more
Journal ArticleDOI
A Multiplexed, Heterogeneous, and Adaptive Code for Navigation in Medial Entorhinal Cortex.
TL;DR: A dynamic and remarkably adaptive code for space that enables entorhinal cells to rapidly encode navigational information accurately at high running speeds is discovered.
Journal ArticleDOI
Internally organized mechanisms of the head direction sense
TL;DR: It is demonstrated that peripheral inputs impinge on an internally organized network, which provides amplification and enhanced precision of the HD signal.
References
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TL;DR: This paper presents a meta-analyses of the determinants of earthquake-triggered landsliding in the Czech Republic over a period of 18 months in order to establish a probabilistic framework for estimating the intensity of the earthquake.
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Millisecond-timescale, genetically targeted optical control of neural activity.
TL;DR: In this paper, the authors adapted the naturally occurring algal protein Channelrhodopsin-2, a rapidly gated light-sensitive cation channel, by using lentiviral gene delivery in combination with high-speed optical switching to photostimulate mammalian neurons.
Journal ArticleDOI
Microstructure of a spatial map in the entorhinal cortex
TL;DR: The dorsocaudal medial entorhinal cortex (dMEC) contains a directionally oriented, topographically organized neural map of the spatial environment, whose key unit is the ‘grid cell’, which is activated whenever the animal's position coincides with any vertex of a regular grid of equilateral triangles spanning the surface of the environment.
Journal ArticleDOI
Dynamics of pattern formation in lateral-inhibition type neural fields
TL;DR: The dynamics of pattern formation is studied for lateral-inhibition type homogeneous neural fields with general connections and it is proved that there are five types of pattern dynamics.