Journal ArticleDOI
Recurrent inhibitory circuitry as a mechanism for grid formation
Jonathan J. Couey,Aree Witoelar,Sheng-Jia Zhang,Kang Zheng,Jing Ye,Benjamin Dunn,Rafal Czajkowski,May-Britt Moser,Edvard I. Moser,Yasser Roudi,Menno P. Witter +10 more
TLDR
It is demonstrated that stellate cells, the principal cell type in the layer II grid network, are mainly interconnected via inhibitory interneurons, and that stable grid firing can emerge from a simple recurrent inhibitory network.Abstract:
Grid cells in layer II of the medial entorhinal cortex form a principal component of the mammalian neural representation of space. The firing pattern of a single grid cell has been hypothesized to be generated through attractor dynamics in a network with a specific local connectivity including both excitatory and inhibitory connections. However, experimental evidence supporting the presence of such connectivity among grid cells in layer II is limited. Here we report recordings from more than 600 neuron pairs in rat entorhinal slices, demonstrating that stellate cells, the principal cell type in the layer II grid network, are mainly interconnected via inhibitory interneurons. Using a model attractor network, we demonstrate that stable grid firing can emerge from a simple recurrent inhibitory network. Our findings thus suggest that the observed inhibitory microcircuitry between stellate cells is sufficient to generate grid-cell firing patterns in layer II of the medial entorhinal cortex.read more
Citations
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Journal ArticleDOI
Regulation of the E/I-balance by the neural matrisome
TL;DR: A review about the role of perineuronal nets for the maturation of parvalbumin-expressing interneurons and summarizes recent findings about the impact of PNNs in different neurological and neuropsychiatric disorders like schizophrenia or epilepsy as mentioned in this paper .
Journal ArticleDOI
Noise-driven bifurcations in a nonlinear Fokker–Planck system describing stochastic neural fields
TL;DR: In this paper , the existence and characterisation of noise-driven bifurcations from the spatially homogeneous stationary states of a nonlinear, non-local Fokker-Planck type partial differential equation describing stochastic neural fields is established.
Dissertation
Parvalbumin+ interneurons enable efficient pattern separation in hippocampal microcircuits
TL;DR: The results demonstrate that PV+interneurons possess unique connectivity and fast signaling properties that confer to the dentate gyrus network properties that allow the emergence of pattern separation, and contribute to the knowledge of how specific forms of network organization underlie sophisticated types of information processing.
Posted ContentDOI
Grid cell disruption in a mouse model of early Alzheimer’s disease reflects reduced integration of self-motion cues
TL;DR: This article showed that grid cells were spatially unstable towards the center of the square arena, had qualitatively different spatial components that aligned parallel to the borders of the environment, and exhibited impaired integration of distance travelled via reduced theta phase precession.
Journal ArticleDOI
Single Cell Transcriptomic and Chromatin Profiles Suggest Layer Vb Is the Only Layer With Shared Excitatory Cell Types in the Medial and Lateral Entorhinal Cortex
TL;DR: It is found that several deep layer excitatory neuronal cell types as defined by chromatin profile are also shared between the two different regions, which is a step forwards into elucidating the cell types within the entorhinal circuit and by extension its functional underpinnings.
References
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Book
The Rat Brain in Stereotaxic Coordinates
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TL;DR: This paper presents a meta-analyses of the determinants of earthquake-triggered landsliding in the Czech Republic over a period of 18 months in order to establish a probabilistic framework for estimating the intensity of the earthquake.
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Nathan C. Shaner,Robert E. Campbell,Robert E. Campbell,Paul Steinbach,Ben N G Giepmans,Amy E. Palmer,Roger Y. Tsien +6 more
TL;DR: The latest red version matures more completely, is more tolerant of N-terminal fusions and is over tenfold more photostable than mRFP1, and three monomers with distinguishable hues from yellow-orange to red-orange have higher quantum efficiencies.
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Millisecond-timescale, genetically targeted optical control of neural activity.
TL;DR: In this paper, the authors adapted the naturally occurring algal protein Channelrhodopsin-2, a rapidly gated light-sensitive cation channel, by using lentiviral gene delivery in combination with high-speed optical switching to photostimulate mammalian neurons.
Journal ArticleDOI
Microstructure of a spatial map in the entorhinal cortex
TL;DR: The dorsocaudal medial entorhinal cortex (dMEC) contains a directionally oriented, topographically organized neural map of the spatial environment, whose key unit is the ‘grid cell’, which is activated whenever the animal's position coincides with any vertex of a regular grid of equilateral triangles spanning the surface of the environment.
Journal ArticleDOI
Dynamics of pattern formation in lateral-inhibition type neural fields
TL;DR: The dynamics of pattern formation is studied for lateral-inhibition type homogeneous neural fields with general connections and it is proved that there are five types of pattern dynamics.