Journal ArticleDOI
Recurrent inhibitory circuitry as a mechanism for grid formation
Jonathan J. Couey,Aree Witoelar,Sheng-Jia Zhang,Kang Zheng,Jing Ye,Benjamin Dunn,Rafal Czajkowski,May-Britt Moser,Edvard I. Moser,Yasser Roudi,Menno P. Witter +10 more
TLDR
It is demonstrated that stellate cells, the principal cell type in the layer II grid network, are mainly interconnected via inhibitory interneurons, and that stable grid firing can emerge from a simple recurrent inhibitory network.Abstract:
Grid cells in layer II of the medial entorhinal cortex form a principal component of the mammalian neural representation of space. The firing pattern of a single grid cell has been hypothesized to be generated through attractor dynamics in a network with a specific local connectivity including both excitatory and inhibitory connections. However, experimental evidence supporting the presence of such connectivity among grid cells in layer II is limited. Here we report recordings from more than 600 neuron pairs in rat entorhinal slices, demonstrating that stellate cells, the principal cell type in the layer II grid network, are mainly interconnected via inhibitory interneurons. Using a model attractor network, we demonstrate that stable grid firing can emerge from a simple recurrent inhibitory network. Our findings thus suggest that the observed inhibitory microcircuitry between stellate cells is sufficient to generate grid-cell firing patterns in layer II of the medial entorhinal cortex.read more
Citations
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Journal ArticleDOI
Degeneracy in the robust expression of spectral selectivity, subthreshold oscillations, and intrinsic excitability of entorhinal stellate cells.
TL;DR: A heterogeneous population of valid SC models built here unveils the robust emergence of cellular-scale physiology despite significant channel heterogeneities, and forms an efficacious substrate for evaluating the impact of biological heterogeneity on entorhinal network function.
Journal ArticleDOI
Multiscale codes in the nervous system: the problem of noise correlations and the ambiguity of periodic scales.
TL;DR: It is shown how periodic, multiscale grid codes can be read out without taking the long-term limit; even on short time scales, the precision of such codes scales exponentially in the number N of neurons.
Journal ArticleDOI
Hippocampus at 25.
Howard Eichenbaum,David G. Amaral,Elizabeth A. Buffalo,György Buzsáki,Neal J. Cohen,Lila Davachi,Loren M. Frank,Stephan Heckers,Richard G. M. Morris,Edvard I. Moser,Lynn Nadel,John O'Keefe,Alison R. Preston,Charan Ranganath,Alcino J. Silva,Menno P. Witter +15 more
TL;DR: In a recent celebration of this event, a Boston memory group invited 16 speakers to address the question of progress in understanding the hippocampus that has been achieved as mentioned in this paper, including the role of temporal organization in spatial and memory processing by the hippocampus, and the integration of related events into networks of memories.
Journal ArticleDOI
Impaired path integration and grid cell spatial periodicity in mice lacking GluA1-containing AMPA receptors.
TL;DR: The hypothesis that spatial representations in the hippocampal–entorhinal network contribute to path integration is supported, indicating that attractor states were still present despite the lack of grid periodicity.
Journal ArticleDOI
Hippocampal function in rodents.
Roland Zemla,Jayeeta Basu +1 more
TL;DR: The functional contribution of newly described long-range connections between hippocampus and cortical areas, and the relative impact of inhibitory and excitatory dynamics in generating behaviorally relevant population activity are highlighted.
References
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The Rat Brain in Stereotaxic Coordinates
George Paxinos,Charles Watson +1 more
TL;DR: This paper presents a meta-analyses of the determinants of earthquake-triggered landsliding in the Czech Republic over a period of 18 months in order to establish a probabilistic framework for estimating the intensity of the earthquake.
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Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein.
Nathan C. Shaner,Robert E. Campbell,Robert E. Campbell,Paul Steinbach,Ben N G Giepmans,Amy E. Palmer,Roger Y. Tsien +6 more
TL;DR: The latest red version matures more completely, is more tolerant of N-terminal fusions and is over tenfold more photostable than mRFP1, and three monomers with distinguishable hues from yellow-orange to red-orange have higher quantum efficiencies.
Journal ArticleDOI
Millisecond-timescale, genetically targeted optical control of neural activity.
TL;DR: In this paper, the authors adapted the naturally occurring algal protein Channelrhodopsin-2, a rapidly gated light-sensitive cation channel, by using lentiviral gene delivery in combination with high-speed optical switching to photostimulate mammalian neurons.
Journal ArticleDOI
Microstructure of a spatial map in the entorhinal cortex
TL;DR: The dorsocaudal medial entorhinal cortex (dMEC) contains a directionally oriented, topographically organized neural map of the spatial environment, whose key unit is the ‘grid cell’, which is activated whenever the animal's position coincides with any vertex of a regular grid of equilateral triangles spanning the surface of the environment.
Journal ArticleDOI
Dynamics of pattern formation in lateral-inhibition type neural fields
TL;DR: The dynamics of pattern formation is studied for lateral-inhibition type homogeneous neural fields with general connections and it is proved that there are five types of pattern dynamics.