Journal ArticleDOI
Redox reactions of hemoglobin.
Joseph M. Rifkind,Somasundaram Ramasamy,Periakaruppan T. Manoharan,Enika Nagababu,Joy G. Mohanty +4 more
TLDR
It is shown how EPR not only identifies the paramagnetic species formed but can also be used to provide insights into the mechanism involved in the redox reactions, and pinpointed the value of using EPR to detect and study theParamagnetic species and free radicals formed during these reactions.Abstract:
Redox reactions of hemoglobin have gained importance because of the general interest of the role of oxidative stress in diseases and the possible role of red blood cells in oxidative stress. Although electron paramagnetic resonance (EPR) is extremely valuable in studying hemoglobin redox reactions it has not been adequately used. We have focused in this review on the important contributions of EPR to our understanding of hemoglobin redox reactions. We have limited our discussion to the redox reactions thought to occur under physiological conditions. This includes autoxidation as well as the reactions of hydrogen peroxide generated by superoxide dismutation. We have also discussed redox reactions associated with nitric oxide produced in the circulation. We have pinpointed the value of using EPR to detect and study the paramagnetic species and free radicals formed during these reactions. We have shown how EPR not only identifies the paramagnetic species formed but can also be used to provide insights into t...read more
Citations
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Journal ArticleDOI
Different faces of the heme-heme oxygenase system in inflammation
Frank A. D. T. G. Wagener,Hans-Dieter Volk,Dean Willis,Nader G. Abraham,Miguel P. Soares,Gosse J. Adema,Carl G. Figdor +6 more
TL;DR: Pre-induction of HO activity has been demonstrated to ameliorate inflammation and mediate potent resistance to oxidative injury and a better understanding of the complex heme-heme.
Journal ArticleDOI
Markers of oxidant stress that are clinically relevant in aging and age-related disease.
TL;DR: DNA, RNA, protein, and lipid oxidation are highlighted as measures of oxidative stress, as well as other well-characterized markers of oxidative damage and inflammation and their strengths and limitations are discussed.
Journal ArticleDOI
Bioavailability and Antioxidant Activity of Black Chokeberry (Aronia melanocarpa) Polyphenols: in vitro and in vivo Evidences and Possible Mechanisms of Action: A Review
TL;DR: It is evident that in vivo antioxidant action of chokeberry extends far beyond radical scavenging and includes suppression of reactive oxygen and nitrogen species formation, inhibition of prooxidant enzymes, restoration of antioxidant enzymes, and probably cellular signaling to regulate the level of antioxidant compounds and enzymes.
Journal ArticleDOI
Mechanisms tagging senescent red blood cells for clearance in healthy humans.
Hans U. Lutz,Anna Bogdanova +1 more
TL;DR: This review focuses on the analysis and evaluation of the diverse senescence markers suggested to prime red blood cells (RBC) for clearance in humans and discusses the relevance of each mechanism and analyzes the strength of the data.
Journal ArticleDOI
Quinoline Drug–Heme Interactions and Implications for Antimalarial Cytostatic versus Cytocidal Activities
TL;DR: The molecular diversity in quinoline-heme molecular interactions is reviewed and important implications for understandingQuinoline antimalarial drug resistance and for future drug design are highlighted.
References
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Book
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TL;DR: In this paper, the authors present a treatment of reaction rates in elementary processes: simple gas-phase reactions, complex reaction in solution, and homogeneous catalysts, and chain reactions.
Journal ArticleDOI
S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control
TL;DR: In this article, the role of S-nitrosohaemoglobin in the transduction of NO-related activities may have therapeutic applications, highlighting newly discovered allosteric and electronic properties of haemoglobin that appear to be involved in the control of blood pressure.
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Peroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide.
TL;DR: In theory, activation could involve (1) heterolysis to OH- and NO2+ (delta rxn Gzero' = 13 kcal/mol at pH 7) or (2) homolysis
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Kinetics and mechanism of the oxidation of human deoxyhemoglobin by nitrites.
TL;DR: The composite experimental results are interpreted to describe alkyl nitrite, and, presumably, nitrous acid association with hemoglobin followed by rate-limiting electron transfer resulting in nitric oxide and alkoxide (or hydroxide) production.
Journal ArticleDOI
Reversible binding of nitric oxide by a salivary heme protein from a bloodsucking insect
TL;DR: Electron paramagnetic resonance and optical spectroscopic experiments indicated that the salivary vasodilator is a nitrosylheme protein with an Fe(III) heme that binds nitric oxide (NO) reversibly, and appears to be the NO carrier that helps R. prolixus to feed on blood.