Reduced perfusion in systemic sclerosis digital ulcers (both fingertip and extensor) can be increased by topical application of glyceryl trinitrate
Michael Hughes,Tonia L. Moore,Joanne Manning,Jack Wilkinson,Graham Dinsdale,Chris Roberts,Andrea Murray,Ariane L. Herrick +7 more
TLDR
DUs were responsive to topical GTN, with an increase in perfusion to the ischaemic DU centre, which has important treatment implications if both fingertip and extensor DUs have a (potentially reversible) ischaemia aetiology.About:
This article is published in Microvascular Research.The article was published on 2017-05-01 and is currently open access. It has received 31 citations till now.read more
Citations
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Journal ArticleDOI
Raynaud phenomenon and digital ulcers in systemic sclerosis.
Michael Hughes,Michael Hughes,Yannick Allanore,Lorinda Chung,John D Pauling,John D Pauling,Christopher P. Denton,Marco Matucci-Cerinic +7 more
TL;DR: The concept of a unified vascular diagnosis could herald the onset of a potential disease-modifying effect in SSc of therapies that affect the vasculature and the authors outline how to assess and treat these conditions, and also discuss unmet clinical needs.
Journal ArticleDOI
Digital Ischemia in COVID-19 Patients: Case Report.
TL;DR: Two cases of critically ill patients with COVID-19 who developed fingertip ischemia while in the intensive care unit are presented in order to better describe the identification and management of this phenomenon.
Journal Article
One year in review 2018: systemic sclerosis.
Martina Orlandi,Simone Barsotti,Gemma Lepri,Veronica Codullo,Marco Di Battista,Serena Guiducci,Alessandra Della Rossa +6 more
TL;DR: An overview of the most significant literature contributions published over the last year on systemic sclerosis is provided.
Journal ArticleDOI
Exploring the patient experience of digital ulcers in systemic sclerosis
TL;DR: How a detailed understanding of the severity and burden of digital ulceration, aetiopathogenesis, and their impact on emotional health, function, work and social participation might inform the development of novel clinical trial outcomes that can support future advances in the assessment and management of digital Ulceration in systemic sclerosis is considered.
Journal ArticleDOI
Novel Optical Techniques for Imaging Microcirculation in the Diabetic Foot.
TL;DR: Although promising, the currently available novel optical techniques need to be further improved technically and prospective trials are necessary to evaluate their clinical value.
References
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Journal Article
Scleroderma (systemic sclerosis): classification, subsets and pathogenesis.
LeRoy Ec,Carol M. Black,Fleischmajer R,Jablonska S,Thomas Krieg,Thomas A. Medsger,N R Rowell,Frank A. Wollheim +7 more
Journal ArticleDOI
Bosentan treatment of digital ulcers related to systemic sclerosis: results from the RAPIDS-2 randomised, double-blind, placebo-controlled trial
Marco Matucci-Cerinic,Christopher P. Denton,Daniel E. Furst,Maureen D. Mayes,Vivien Hsu,Patrick H. Carpentier,Fredrick M. Wigley,Carol M. Black,Barri J. Fessler,Peter A. Merkel,Janet E. Pope,Nadera J. Sweiss,Mittie K. Doyle,Mittie K. Doyle,Bernhard Hellmich,Thomas A. Medsger,Adele Morganti,Fabrice Kramer,Joseph H. Korn,James R. Seibold +19 more
TL;DR: Bosentan treatment reduced the occurrence of new DUs in patients with SSc but had no effect on DU healing and may be a useful adjunct in the management of patients withSSc with recurrent DUs.
Journal Article
Natural history of ischemic digital ulcers in systemic sclerosis: single-center retrospective longitudinal study.
Eric Hachulla,Pierre Clerson,David Launay,Marc Lambert,Sandrine Morell-Dubois,Viviane Queyrel,Pierre-Yves Hatron +6 more
TL;DR: Patients who are young at first sign of SSc, with high Rodnan scores and without vasodilator therapy, are at high risk of developing DU.
Journal ArticleDOI
Efficacy of sildenafil on ischaemic digital ulcer healing in systemic sclerosis: the placebo-controlled SEDUCE study
Eric Hachulla,Pierre-Yves Hatron,Patrick Carpentier,Christian Agard,Emmanuel Chatelus,Patrick Jego,Luc Mouthon,Viviane Queyrel,Anne-Laure Fauchais,Ulrique Michon-Pasturel,Roland Jaussaud,Alexis Mathian,Brigitte Granel,Elisabeth Diot,Dominique Farge-Bancel,Arsène Mekinian,Jérôme Avouac,Hélène Desmurs-Clavel,Pierre Clerson +18 more
TL;DR: A significant decrease in the number of DUs in favour of sildenafil compared with placebo at W8 and W12, confirming a sildanafil benefit.
Journal ArticleDOI
Digital ulcers predict a worse disease course in patients with systemic sclerosis.
Carina Mihai,Robert Landewé,Désirée van der Heijde,Ulrich A. Walker,Paul I Constantin,Ana Maria Gherghe,Ruxandra Ionescu,Simona Rednic,Yannick Allanore,Jérôme Avouac,László Czirják,Eric Hachulla,Gabriela Riemekasten,Franco Cozzi,Paolo Airò,Maurizio Cutolo,Ulf Mueller-Ladner,Marco Matucci-Cerinic +17 more
TL;DR: In patients with SSc, HDU at presentation predicts the occurrence of DUs at follow-up and is associated with cardiovascular worsening and decreased survival.
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