Reduced sensitivity of influenza A (H5N1) to oseltamivir.
TLDR
All viruses demonstrated similar sensitivity to zanamivir, but compared to the 2004 clade 1 viruses, the Cambodian 2005 viruses were 6-fold less sensitive and the Indonesian clade 2 viruses were up to 30-fold more sensitive to oseltamiviral.Abstract:
We tested the neuraminidase drug sensitivity of clade 1 and clade 2 influenza A virus (H5N1). All viruses demonstrated similar sensitivity to zanamivir, but compared to the 2004 clade 1 viruses, the Cambodian 2005 viruses were 6-fold less sensitive and the Indonesian clade 2 viruses were up to 30-fold less sensitive to oseltamivir.read more
Citations
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Update on avian influenza A (H5N1) virus infection in humans.
Abdel-Ghafar An,Tawee Chotpitayasunondh,Zhancheng Gao,Frederick G Hayden,Nguyen Dh,de Jong,Naghdaliyev A,Peiris Js,Nikki Shindo,Santoso Soeroso,Timothy M. Uyeki +10 more
TL;DR: The members of the writing committee (Abdel-Nasser Abdel-Ghafar, M.D., Tawee Chotpitayasunondh,M.D, Ph.D), and Timothy M. Uyeki assume responsibility for the overall content and integrity of the article.
Update on Avian Influenza A (H5N1) Virus Infection in Humans Writing Committee of the Second World Health Organization Consultation on Clinical Aspects of Human Infection with Avian Influenza A (H5N1) Virus
Abdel-Nasser Abdel-Ghafar,Frederick G. Hayden,Nguyen Duc Hien,Menno D. de Jong,Nahoko Shindo,Santoso Soeroso,Timothy M. Uyeki +6 more
TL;DR: Hayden et al. as mentioned in this paper assume responsibility for the overall content and integrity of the article, and the members of the writing committee (Abdel-Nasser Abdel-Ghafar, M.D.
Journal ArticleDOI
Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants.
Patrick J. Collins,Lesley F. Haire,Yi Pu Lin,Junfeng Liu,Rupert J. Russell,Philip A. Walker,John J. Skehel,Stephen R. Martin,Alan Hay,Steven J. Gamblin +9 more
TL;DR: The enzymatic properties and crystal structures of neuraminidase mutants from H5N1-infected patients are reported that explain the molecular basis of resistance and indicate that it would be prudent for pandemic stockpiles of oseltamivir to be augmented by additional antiviral drugs, including zanamivIR.
Journal ArticleDOI
Influenza neuraminidase inhibitors: antiviral action and mechanisms of resistance
TL;DR: McKimm‐Breschkin (2012) Influenza neuraminidase inhibitors: Antiviral action and mechanisms of resistance.
Journal ArticleDOI
Findings from a household randomized controlled trial of hand washing and face masks to reduce influenza transmission in Bangkok, Thailand.
James Mark Simmerman,Piyarat Suntarattiwong,Jens W. Levy,Richard G. Jarman,Suchada Kaewchana,Robert V. Gibbons,BJ Cowling,Wiwan Sanasuttipun,Susan A. Maloney,Timothy M. Uyeki,Laurie Kamimoto,Tawee Chotipitayasunondh +11 more
TL;DR: Findings from a household randomized controlled trial of hand washing and face masks to reduce influenza transmission in Bangkok, Thailand are significant and need to be investigated further.
References
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Resistant influenza A viruses in children treated with oseltamivir: descriptive study
Maki Kiso,Keiko Mitamura,Yuko Sakai-Tagawa,Kyoko Shiraishi,Chiharu Kawakami,Kazuhiro Kimura,Frederick G. Hayden,Norio Sugaya,Yoshihiro Kawaoka,Yoshihiro Kawaoka +9 more
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The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design
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TL;DR: It may be possible to exploit the size and location of the group-1 cavity to develop new anti-influenza drugs, according to X-ray crystallography, which shows that these two groups of neuraminidases are structurally distinct.
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TL;DR: The isolation of an H5N1 virus from a Vietnamese girl that is resistant to the drug oseltamivir, which is an inhibitor of the viral enzyme neuraminidase and is currently used for protection against and treatment of influenza is reported.
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Detection of Influenza Viruses Resistant to Neuraminidase Inhibitors in Global Surveillance during the First 3 Years of Their Use
Arnold S. Monto,Jennifer L. McKimm-Breschkin,Catherine A. Macken,Alan W. Hampson,Alan J. Hay,Alexander Klimov,Masato Tashiro,Robert G. Webster,Michelle Aymard,Frederick G. Hayden,Maria Zambon +10 more
TL;DR: The frequency of variants with decreased sensitivity to the NAIs did not increase significantly during this period, but continued surveillance is required, especially in regions with higher NAI use.
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Emergence and predominance of an H5N1 influenza variant in China
Gavin J. D. Smith,Xiaohui Fan,Jin Wang,Kenneth S. M. Li,K. Qin,Jinxia Zhang,Dhanasekaran Vijaykrishna,CL Cheung,Kai Huang,J. M. Rayner,Joseph S. M. Peiris,Honglin Chen,Robert G. Webster,Yi Guan +13 more
TL;DR: Genetic and antigenic analyses revealed the emergence and predominance of a previously uncharacterized H5N1 virus sublineage (Fujian-like) in poultry since late 2005, resulting in a new transmission and outbreak wave in Southeast Asia.