Reduction in oxidatively generated DNA damage following smoking cessation.
Harold C. Box,Richard J O'Connor,Helen B. Patrzyc,Herbert Iijima,Jean B. Dawidzik,Harold G. Freund,Edwin E. Budzinski,K. Michael Cummings,Martin C. Mahoney +8 more
TLDR
Results from this analysis suggest that cigarette smoking contributes to oxidatively induced DNA damage, and that smoking cessation appears to reduce levels of specific damage markers between 30-50 percent in the short term.Abstract:
Background
Cigarette smoking is a known cause of cancer, and cancer may be in part due to effects of oxidative stress. However, whether smoking cessation reverses oxidatively induced DNA damage unclear. The current study sought to examine the extent to which three DNA lesions showed significant reductions after participants quit smoking.read more
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Wirkungen von Menthol als Zusatzstoff in Tabakprodukten und die Notwendigkeit einer Regulierung
TL;DR: The effect of menthol as an additive in tobacco products and its effect on tobacco consumption that causes a number of chronic diseases and premature death and, therefore, counteracts tobacco control measures is summarized.
Journal ArticleDOI
Pyrimidine base damage is increased in women with BRCA mutations.
Edwin E. Budzinski,Helen B. Patrzyc,Jean B. Dawidzik,Harold G. Freund,Peter J. Frederick,Heidi Godoy,Nicoleta C. Voian,Kunle Odunsi,Harold C. Box +8 more
TL;DR: The experimental design utilized DNA from WBC and employed LC-MS/MS to detect the lesions, which employed a formamide remnant of pyrimidine base and the glycol modification of thymine as valuable indicators of oxidative stress.
References
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