Reduction in oxidatively generated DNA damage following smoking cessation.
Harold C. Box,Richard J O'Connor,Helen B. Patrzyc,Herbert Iijima,Jean B. Dawidzik,Harold G. Freund,Edwin E. Budzinski,K. Michael Cummings,Martin C. Mahoney +8 more
TLDR
Results from this analysis suggest that cigarette smoking contributes to oxidatively induced DNA damage, and that smoking cessation appears to reduce levels of specific damage markers between 30-50 percent in the short term.Abstract:
Background
Cigarette smoking is a known cause of cancer, and cancer may be in part due to effects of oxidative stress. However, whether smoking cessation reverses oxidatively induced DNA damage unclear. The current study sought to examine the extent to which three DNA lesions showed significant reductions after participants quit smoking.read more
Citations
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Smoking and increased Alzheimer's disease risk: A review of potential mechanisms
Timothy C. Durazzo,Timothy C. Durazzo,Niklas Mattsson,Niklas Mattsson,Niklas Mattsson,Michael W. Weiner +5 more
TL;DR: Cigarette smoking has been linked with both increased and decreased risk for Alzheimer's disease (AD), which is relevant for the US military because the prevalence of smoking in the military is approximately 11% higher than in civilians.
Journal ArticleDOI
Occurrence, Biological Consequences, and Human Health Relevance of Oxidative Stress-Induced DNA Damage
TL;DR: The continuing development and improvement of LC-MS/MS coupled with the stable isotope-dilution method for DNA adduct quantification will further promote research about the clinical implications and diagnostic applications of oxidatively induced DNAAdducts.
Journal ArticleDOI
Mononuclear leukocyte DNA damage and oxidative stress: the association with smoking of hand-rolled and filter-cigarettes.
TL;DR: It is indicated that smoking of hand-rolled cigarettes has stronger genotoxic and oxidative effects on the metabolism than smoking of manufactured filter-cigarettes, and it is proposed that these harmful effects could be attributed to the higher level of oxidants.
Journal ArticleDOI
Obesity and inflammation markers in relation to leukocyte telomere length in a cross-sectional study of persons with Barrett’s esophagus
Sheetal Hardikar,Sheetal Hardikar,Xiaoling Song,Rosa Ana Risques,Thomas J. Montine,Catherine Duggan,Patricia L. Blount,Patricia L. Blount,Brian J. Reid,Garnet L. Anderson,Garnet L. Anderson,Mario Kratz,Mario Kratz,Emily White,Emily White,Thomas L. Vaughan,Thomas L. Vaughan +16 more
TL;DR: Increasing age, male gender, smoking history, and sTNF-RI levels were associated with short LTL among persons with BE but no correlations were observed between LTL and other inflammatory markers or measures of obesity.
Journal ArticleDOI
The influence of active and passive smoking during pregnancy on umbilical cord blood levels of vitamins A and E and neonatal anthropometric indices
Olga E. Titova,Elena A. Ayvazova,Fatima A. Bichkaeva,Samantha J. Brooks,Galina N. Chumakova,Helgi B. Schiöth,Christian Benedict +6 more
TL;DR: An inverse association between smoking behaviour during pregnancy and birth length was observed, with shortest length in active smokers followed by passive smoking mothers, and the observed increase in umbilical cord serum levels of vitamins A and E may subserve antioxidative processes in response to tobacco smoke-induced oxidative stress.
References
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Journal ArticleDOI
Differences in DNA-damage in non-smoking men and women exposed to environmental tobacco smoke (ETS).
TL;DR: It was found that despite equivalent ETS exposure, significantly greater DNA-damage occurred in men than women, which may begin to provide a mechanistic rationale for the generally higher incidence of some diseases in males due to tobacco smoke and/or other genotoxic stressors.
Journal ArticleDOI
A study of pyrimidine base damage in relation to oxidative stress and cancer
Herbert Iijima,Helen B. Patrzyc,Edwin E. Budzinski,Harold G. Freund,Jean B. Dawidzik,K J Rodabaugh,Harold C. Box +6 more
TL;DR: The results in combination with other published measurements of oxidative DNA damage support the hypothesis that oxidative damage, on average, is higher in WBC of cancer patients than in healthy controls.
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A novel approach to DNA damage assessments: measurement of the thymine glycol lesion.
Douglas T. Bailey,Han-Chun DeFedericis,Kellee F. Greene,Herbert Iijima,Edwin E. Budzinski,Helen B. Patrzyc,Jean B. Dawidzik,Harold C. Box +7 more
TL;DR: Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is used in conjunction with isotopically labeled internal standards to quantify the Thymine Glycol Lesion and has several advantages, including high sensitivity for the detection of dinucleoside monophosphates.
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Assessment of DNA damage at the dimer level: measurement of the formamide lesion.
Kellee F. Greene,Edwin E. Budzinski,Herbert Iijima,Jean B. Dawidzik,Han-Chun DeFedericis,Helen B. Patrzyc,Marianne S. Evans,Douglas T. Bailey,Harold G. Freund,Harold C. Box +9 more
TL;DR: Both UVC radiation and tirapazamine produce markedly different profiles of DNA damage, reflecting their respective mechanisms of action, but only the former produced a measurable amount of the 8-oxo-7,8-dihydroguanine lesion.
Journal ArticleDOI
The 1-Carbamoyl-2-oxo-4,5-dihydroxyimidazolidine Component of ROS-Induced DNA Damage in White Blood Cells
Herbert Iijima,Helen B. Patrzyc,Edwin E. Budzinski,Jean B. Dawidzik,Harold G. Freund,Harold C. Box +5 more
TL;DR: The background level of the 1-carbamoyl-2-oxo-4,5-dihydroxyimidazolidine modification of cytosine was found to be larger than the levels of the formamide and thymine glycol base modifications.