Reduction in oxidatively generated DNA damage following smoking cessation.
Harold C. Box,Richard J O'Connor,Helen B. Patrzyc,Herbert Iijima,Jean B. Dawidzik,Harold G. Freund,Edwin E. Budzinski,K. Michael Cummings,Martin C. Mahoney +8 more
TLDR
Results from this analysis suggest that cigarette smoking contributes to oxidatively induced DNA damage, and that smoking cessation appears to reduce levels of specific damage markers between 30-50 percent in the short term.Abstract:
Background
Cigarette smoking is a known cause of cancer, and cancer may be in part due to effects of oxidative stress. However, whether smoking cessation reverses oxidatively induced DNA damage unclear. The current study sought to examine the extent to which three DNA lesions showed significant reductions after participants quit smoking.read more
Citations
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Journal ArticleDOI
Smoking and increased Alzheimer's disease risk: A review of potential mechanisms
Timothy C. Durazzo,Timothy C. Durazzo,Niklas Mattsson,Niklas Mattsson,Niklas Mattsson,Michael W. Weiner +5 more
TL;DR: Cigarette smoking has been linked with both increased and decreased risk for Alzheimer's disease (AD), which is relevant for the US military because the prevalence of smoking in the military is approximately 11% higher than in civilians.
Journal ArticleDOI
Occurrence, Biological Consequences, and Human Health Relevance of Oxidative Stress-Induced DNA Damage
TL;DR: The continuing development and improvement of LC-MS/MS coupled with the stable isotope-dilution method for DNA adduct quantification will further promote research about the clinical implications and diagnostic applications of oxidatively induced DNAAdducts.
Journal ArticleDOI
Mononuclear leukocyte DNA damage and oxidative stress: the association with smoking of hand-rolled and filter-cigarettes.
TL;DR: It is indicated that smoking of hand-rolled cigarettes has stronger genotoxic and oxidative effects on the metabolism than smoking of manufactured filter-cigarettes, and it is proposed that these harmful effects could be attributed to the higher level of oxidants.
Journal ArticleDOI
Obesity and inflammation markers in relation to leukocyte telomere length in a cross-sectional study of persons with Barrett’s esophagus
Sheetal Hardikar,Sheetal Hardikar,Xiaoling Song,Rosa Ana Risques,Thomas J. Montine,Catherine Duggan,Patricia L. Blount,Patricia L. Blount,Brian J. Reid,Garnet L. Anderson,Garnet L. Anderson,Mario Kratz,Mario Kratz,Emily White,Emily White,Thomas L. Vaughan,Thomas L. Vaughan +16 more
TL;DR: Increasing age, male gender, smoking history, and sTNF-RI levels were associated with short LTL among persons with BE but no correlations were observed between LTL and other inflammatory markers or measures of obesity.
Journal ArticleDOI
The influence of active and passive smoking during pregnancy on umbilical cord blood levels of vitamins A and E and neonatal anthropometric indices
Olga E. Titova,Elena A. Ayvazova,Fatima A. Bichkaeva,Samantha J. Brooks,Galina N. Chumakova,Helgi B. Schiöth,Christian Benedict +6 more
TL;DR: An inverse association between smoking behaviour during pregnancy and birth length was observed, with shortest length in active smokers followed by passive smoking mothers, and the observed increase in umbilical cord serum levels of vitamins A and E may subserve antioxidative processes in response to tobacco smoke-induced oxidative stress.
References
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Book ChapterDOI
Oxidative damage to DNA: formation, measurement, and biological significance.
Journal ArticleDOI
Tobacco smoke: involvement of reactive oxygen species and stable free radicals in mechanisms of oxidative damage, carcinogenesis and synergistic effects with other respirable particles.
TL;DR: Results showed that the semiquinone radical system has the potential for redox recycling and oxidative action and proved that aqueous cigarette tar (ACT) solutions can generate adducts with DNA nucleobases, particularly the mutagenic 8-hydroxy-2’-deoxyguanosine (a biomarker for carcinogenesis).
Journal Article
Role of oxidative DNA damage in cancer initiation and promotion.
TL;DR: Within DNA, hot-spots of oxidative modification and subsequent mutation have been described, and some specificity appears as compared to other agents that can lead to modification of DNA, i.e. aflatoxin and benzo[a]pyrene.
Journal ArticleDOI
Cigarette smoking induces an increase in oxidative DNA damage, 8-hydroxydeoxyguanosine, in a central site of the human lung
Shinya Asami,Hideo Manabe,Jun Miyake,Yosuke Tsurudome,Takeshi Hirano,Raizo Yamaguchi,Hideaki Itoh,Hiroshi Kasai +7 more
TL;DR: It is suggested that oxidative DNA damage is induced in lung DNA by cigarette smoking.