Journal ArticleDOI
Reduction of Serum Cholesterol in Postmenopausal Women With Previous Myocardial Infarction and Cholesterol Malabsorption Induced by Dietary Sitostanol Ester Margarine Women and Dietary Sitostanol
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TLDR
Dietary use of sitostanol ester margarine normalizes LDL cholesterol in about one third of women with previous myocardial infarction, especially in those with high baseline absorption and low synthesis of cholesterol, and in combination with statins reduces the needed drug dose.Abstract:
Background Reduction of serum cholesterol decreases mortality in primary and especially in secondary prevention. We investigated how effectively postmenopausal women with a previous myocardial infa...read more
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Journal ArticleDOI
Bioactive compounds in foods: their role in the prevention of cardiovascular disease and cancer
Penny M. Kris-Etherton,Kari D Hecker,Andrea Bonanome,Stacie M. Coval,Amy E. Binkoski,Kirsten F Hilpert,Amy E. Griel,Terry D. Etherton +7 more
TL;DR: Many bioactive compounds are extranutritional constituents that typically occur in small quantities in foods and are grouped accordingly as phenolic compounds, including their subcategory, flavonoids as discussed by the authors.
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AHA Dietary Guidelines Revision 2000: A Statement for Healthcare Professionals From the Nutrition Committee of the American Heart Association
Ronald M. Krauss,Robert H. Eckel,Barbara V. Howard,Lawrence J. Appel,Stephen R. Daniels,Richard J. Deckelbaum,John W. Erdman,Penny M. Kris-Etherton,Ira J. Goldberg,Theodore A. Kotchen,Alice H. Lichtenstein,William E. Mitch,Rebecca M. Mullis,Killian Robinson,Judith Wylie-Rosett,Sachiko T. St. Jeor,John Suttie,Diane L. Tribble,Terry L. Bazzarre +18 more
TL;DR: In this paper, the authors present guidelines for reducing the risk of cardiovascular disease by dietary and other lifestyle practices, which place increased emphasis on foods and an overall eating pattern and the need for all Americans to achieve and maintain a healthy body weight.
Journal ArticleDOI
AHA Dietary Guidelines Revision 2000: A Statement for Healthcare Professionals From the Nutrition Committee of the American Heart Association
Ronald M. Krauss,Robert H. Eckel,Barbara V. Howard,Lawrence J. Appel,Stephen R. Daniels,Richard J. Deckelbaum,John W. Erdman,Penny M. Kris-Etherton,Ira J. Goldberg,Theodore A. Kotchen,Alice H. Lichtenstein,William E. Mitch,Rebecca M. Mullis,Killian Robinson,Judith Wylie-Rosett,Sachiko T. St. Jeor,John Suttie,Diane L. Tribble,Terry L. Bazzarre +18 more
TL;DR: The overall approach has been modified to emphasize their relation to specific goals that the AHA considers of greatest importance for lowering the risk of heart disease and stroke and increased emphasis on foods and an overall eating pattern.
Journal ArticleDOI
Efficacy and Safety of Plant Stanols and Sterols in the Management of Blood Cholesterol Levels
Martijn B. Katan,Scott M. Grundy,Peter B. Jones,Malcolm Law,Tatu A. Miettinen,Rodolfo Paoletti +5 more
TL;DR: Present evidence is sufficient to promote use of sterols and stanols for lowering LDL cholesterol levels in persons at increased risk for coronary heart disease.
Journal ArticleDOI
Plant sterols: biosynthesis, biological function and their importance to human nutrition.
TL;DR: Since the morbidity and mortality from cardiovascular disease have been dramatically reduced using cholesterol-lowering drugs (statins), the interest in plant sterols lies in their potential to act as a natural preventive dietary product.
References
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Journal ArticleDOI
Optimizing the effect of plant sterols on cholesterol absorption in man.
TL;DR: It is indicated that the judicious addition of beta-sitosterol orbeta-sitosteryl oleate to meals containing cholesterol-rich foods will result in a significant decrease in cholesterol absorption, with a consequent decrease in plasma cholesterol.
Journal ArticleDOI
Serum cholesterol and cholesterol and lipoprotein metabolism in hypercholesterolaemic NIDDM patients before and during sitostanol ester-margarine treatment.
Helena Gylling,Tatu A. Miettinen +1 more
TL;DR: It is concluded that the sitostanol ester-induced decrease in cholesterol absorption compensatorily stimulated cholesterol synthesis, had no effect on fractional catabolic rate, but decreased transport rate for LDL apoprotein B so that serum total, VLDL and LDL cholesterol levels were decreased.
Journal ArticleDOI
Cholesterol absorption: regulation of cholesterol synthesis and elimination and within-population variations of serum cholesterol levels.
Tatu A. Miettinen,Y A Kesäniemi +1 more
TL;DR: Cholesterol absorption efficiency and absorbed dietary cholesterol significantly regulate cholesterol synthesis and elimination and are important determinants of within-population variation in the serum levels of total, LDL, and HDL cholesterol.
Journal ArticleDOI
Serum cholesterol, cholesterol precursors, and plant sterols in hypercholesterolemic subjects with different apoE phenotypes during dietary sitostanol ester treatment
Hannu Vanhanen,S. Blomqvist,Christian Ehnholm,M Hyvönen,Matti Jauhiainen,I Torstila,Tatu A. Miettinen +6 more
TL;DR: It is demonstrated that sitostanol esters dissolved in dietary fat can be recommended for treatment of modest primary hypercholesterolemia and are apparently practical and suitable for cholesterol lowering in a general population.
Journal ArticleDOI
Effects of inhibiting cholesterol absorption and synthesis on cholesterol and lipoprotein metabolism in hypercholesterolemic non-insulin-dependent diabetic men.
Helena Gylling,Tatu A. Miettinen +1 more
TL;DR: A combination of statin to sitostanol ester margarine-resistant patients offers a safe and effective measure to normalize abnormally high cholesterol values, probably with a lowered statin dose.
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