Regular and low-dose aspirin, other non-steroidal anti-inflammatory medications and prospective risk of HER2-defined breast cancer: the California Teachers Study.
Christina A. Clarke,Christina A. Clarke,Alison J. Canchola,Lisa M. Moy,Lisa M. Moy,Susan L. Neuhausen,Nadia T. Chung,James V. Lacey,Leslie Bernstein +8 more
TLDR
This is the first report to suggest that the reduction in risk of breast cancer occurs for low-dose aspirin and not for regular- dose aspirin and only among women with the hormone receptor-positive/HER2-negative subtype.Abstract:
Regular users of aspirin may have reduced risk of breast cancer. Few studies have addressed whether risk reduction pertains to specific breast cancer subtypes defined jointly by hormone receptor (estrogen and progesterone receptor) and human epidermal growth factor receptor 2 (HER2) expression. This study assessed the prospective risk of breast cancer (overall and by subtype) according to use of aspirin and other non-steroidal anti-inflammatory medications (NSAIDs) in a cohort of female public school professionals in California. In 1995 − 1996, participants in the California Teachers Study completed a baseline questionnaire on family history of cancer and other conditions, use of NSAIDs, menstrual and reproductive history, self-reported weight and height, living environment, diet, alcohol use, and physical activity. In 2005–2006, 57,164 participants provided some updated information, including use of NSAIDs and 1457 of these participants developed invasive breast cancer before January 2013. Multivariable Cox proportional hazards regression models provided hazard rate ratios (HRR) for the association between NSAID use and risk of invasive breast cancer as well as hormone receptor- and HER2-defined subtypes. Developing breast cancer was associated inversely with taking three or more tablets of low-dose aspirin per week (23% of participants). Among women reporting this exposure, the HRR was 0.84 (95% confidence interval (CI) 0.72–0.98) compared to those not taking NSAIDs and this was particularly evident in women with the hormone receptor-positive/HER2-negative subtype (HRR = 0.80, 95% CI 0.66–0.96). Use of three or more tablets of “other” NSAIDs was marginally associated with lower risk of breast cancer (HRR = 0.79, 95% CI 0.62–1.00). Other associations with NSAIDs were generally null. Our observation of reduced risk of breast cancer, among participants who took three or more tablets of low-dose aspirin weekly, is consistent with other reports looking at aspirin without differentiation by dose. This is the first report to suggest that the reduction in risk occurs for low-dose aspirin and not for regular-dose aspirin and only among women with the hormone receptor-positive/HER2-negative subtype. This preliminary study builds on previous knowledge and further supports the need for formal cancer chemoprevention studies of low-dose aspirin.read more
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Lifestyle Medicine: A Brief Review of Its Dramatic Impact on Health and Survival.
Balazs I Bodai,Therese E Nakata,William T Wong,Dawn R Clark,Steven Lawenda,Christine Tsou,Raymond W. Liu,Linda Shiue,Neil Cooper,Michael Rehbein,Benjamin P Ha,Anne McKeirnan,Rajiv Misquitta,Pankaj Vij,Andrew Klonecke,Carmelo S Mejia,Emil Dionysian,Sean Hashmi,Michael Greger,Scott R Stoll,Thomas M. Campbell +20 more
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References
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Journal ArticleDOI
Low-Dose Aspirin in the Primary Prevention of Cancer: The Women’s Health Study: A Randomized Controlled Trial
Nancy R. Cook,I-Min Lee,J. Michael Gaziano,David Gordon,Paul M. Ridker,JoAnn E. Manson,Charles H. Hennekens,Julie E. Buring +7 more
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Journal ArticleDOI
Clinicopathologic features, patterns of recurrence, and survival among women with triple‐negative breast cancer in the National Comprehensive Cancer Network
Nan Lin,Ann Vanderplas,Melissa E. Hughes,Richard L. Theriault,Stephen B. Edge,Yu-Ning Wong,Douglas W. Blayney,Douglas W. Blayney,Joyce C. Niland,Eric P. Winer,Jane C. Weeks +10 more
TL;DR: Clinopathologic features, patterns of recurrence, and survival according to breast cancer subtype with a focus on triple‐negative tumors are described.
Journal Article
Breast Cancer and Nonsteroidal Anti-Inflammatory Drugs Prospective Results from the Women’s Health Initiative
Randall E. Harris,Rowan T. Chlebowski,Rebecca D. Jackson,David J. Frid,Joao L. Ascenseo,Garnet L. Anderson,Aimee Loar,Rebecca J. Rodabough,Emily White,Anne McTiernan +9 more
TL;DR: It is indicated that the regular use of aspirin, ibuprofen, or other NSAIDs may have a significant chemopreventive effect against the development of breast cancer and underscore the need for clinical trials to confirm this effect.
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