Relationship between Fatty-Acid Composition of Platelets and Platelet Aggregation in Rat and Man RELATION TO THROMBOSIS
TLDR
In both the rat and man, a high thrombotic tendency may be associated with a platelet hypersusceptibility to thrombin which, in turn, is related to changes in fatty-acid composition.Abstract:
Male rats fed a diet rich in butter or stearic acid presented a marked predisposition to endotoxin-initiated thrombosis. This was preceded by hypercholesterolemia, hypercoagulability, and an increased susceptibility of platelets to thrombin-induced aggregation. In contrast to this, feeding of corn oil or linoleic or oleic acids did not result in such marked changes in the blood or in severe thrombosis. Gas-liquid chromatographic analysis of total lipids of platelet and plasma indicated that the thrombogenic fat or fatty acid resulted in a highly significant increase, mostly in the platelets, of the ratio of saturated + monounsaturated to polyunsaturated fatty acids (S+M)/P. In patients who had suffered a myocardial infarction as compared with men without risk factors for coronary heart disease, an increase in the (S+M)/P in plasma and platelets was also observed. Among 17 active middle-aged businessmen, the five who presented signs of coronary heart disease also showed the highest susceptibility to thrombin-induced aggregation, but not to ADP or collagen. In these 17 subjects, the results of the thrombin aggregation could be correlated with the platelet (S+M)/P, but not with the plasma or platelet cholesterol. In both the rat and man, a high thrombotic tendency may be associated with a platelet hypersusceptibility to thrombin which, in turn, is related to changes in fatty-acid composition.read more
Citations
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Journal ArticleDOI
The effect of vitamin E on platelet aggregation.
TL;DR: If tocopherol acetate (vitamin E) has any beneficial effect on the prevention of thromboemolism or in the treatment of angina pectoris and peripheral vascular disease, it is not via inhibition of platelet aggregation.
Journal ArticleDOI
Effect of dietary (n--3) fatty acids on platelet function and lipid metabolism in rats.
TL;DR: The (n--3) fatty acids added in small amounts to a saturated fat diet over a period of several months induced drastic changes in platelet lipid metabolism and composition without comparable effects on platelet behaviour.
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The role of dietary polyunsaturated fatty acids and prostaglandins in reducing blood pressure and improving thrombogenic indices.
J M Iacono,R.M. Dougherty +1 more
TL;DR: Results of dietary studies performed at Beltsville, Maryland, have demonstrated that under controlled dietary conditions, blood pressure can be lowered and platelet aggregation indices can be improved in men and women in the 40-60 age group.
Journal ArticleDOI
Endotoxin Levels Are Associated With High-Density Lipoprotein, Triglycerides, and Troponin in Patients With Acute Coronary Syndrome and Angina: Possible Contributions From Periodontal Sources
David Goteiner,David Goteiner,Ronald G. Craig,Robert Ashmen,Malvin N. Janal,Barnet Eskin,Neal Lehrman +6 more
TL;DR: Subjects with ACS or angina were more likely to have poor oral care, fewer remaining teeth, and increased alveolar radiographic bone loss compared to subjects with chest pain.
Journal ArticleDOI
Influence of vitamin E administration on platelet functions in hormonal contraceptive users
Serge Renaud,Maryvonne Ciavatti,Laurence Perrot,François Berthezène,Daniel Dargent,Pjerre Condamin +5 more
TL;DR: The present pilot study suggests that the platelet hyperactivity of long-term hormonal contraceptive users might be dependent upon a low level of platelet alpha-tocopherol which can be rapidly overcome by giving a supplement of vitamin E.
References
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