Journal ArticleDOI
Repeated fed-batch process for improving lovastatin production.
TLDR
Submerged cultivation of a high yielding strain of Aspergillus terreus DRCC 122 for the production of lovastatin in the batch process had limited success, but a cost effective repeated fed-batch process with maltodextrin and corn steep liquor feed as carbon and nitrogen sources, respectively, showed a significant increase in Lovastatin yield.About:
This article is published in Process Biochemistry.The article was published on 2000-11-01. It has received 96 citations till now. The article focuses on the topics: Corn steep liquor.read more
Citations
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Journal ArticleDOI
Production of microbial secondary metabolites: Regulation by the carbon source
Beatriz Ruiz,Adán Chávez,Angela Forero,Yolanda García-Huante,Alba Romero,Mauricio Sánchez,Diana Rocha,Brenda Sánchez,Romina Rodríguez-Sanoja,Sergio Sánchez,Elizabeth Langley +10 more
TL;DR: The aim of the present review is to describe important advances reported on mechanisms to explain the negative carbon catabolite effects on secondary metabolite production in bacteria and fungi, giving special emphasis to those reported for the genus Streptomyces.
Journal ArticleDOI
Production of lovastatin by Aspergillus terreus: effects of the C:N ratio and the principal nutrients on growth and metabolite production
J.L. Casas López,J.A. Sánchez Pérez,J. M. Fernández Sevilla,F.G. Acién Fernández,E. Molina Grima,Yusuf Chisti +5 more
TL;DR: Production of lovastatin and microbial biomass by Aspergillus terreus ATCC 20542 were influenced by the type of the carbon source and the nitrogen source used, and the use of spores gave a more consistent inoculum in the different runs.
Journal ArticleDOI
Biotechnological production and applications of statins.
TL;DR: Advances in the biochemistry and genetics of lovastatin have allowed the development of new methods for the production of simvastatin, the second leading statin in the market, which is a Lovastatin semisynthetic derivative.
Journal ArticleDOI
Pellet morphology, culture rheology and lovastatin production in cultures of Aspergillus terreus.
J.L. Casas López,J.A. Sánchez Pérez,J. M. Fernández Sevilla,E.M. Rodríguez Porcel,Yusuf Chisti +4 more
TL;DR: Both an upper limit on agitation intensity and a high level of dissolved oxygen are essential for attaining high titers of lovastatin in fungal pellet morphology and broth rheology.
Journal ArticleDOI
Lovastatin production by solid state fermentation using Aspergillus flavipes
TL;DR: In this article, Aspergillus flavipes BICC 5174 was used for the production of lovastatin by solid state fermentation (SSF) using different solid substrates such as wheat bran, bagasse, barley, soybean meal, gram bran and fruits waste and some of their combinations were tested for Lovastatin production.
References
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Journal ArticleDOI
Colorimetric Method for Determination of Sugars and Related Substances
TL;DR: In this article, a method was developed to determine submicro amounts of sugars and related substances using a phenol-sulfuric acid reaction, which is useful for the determination of the composition of polysaccharides and their methyl derivatives.
Journal ArticleDOI
Use of Dinitrosalicylic Acid Reagent for Determination of Reducing Sugar
Journal ArticleDOI
Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.
Alfred W. Alberts,Julie S. Chen,G Kuron,V Hunt,Jesse W. Huff,Carl H. Hoffman,John W. Rothrock,Lopez Maria B,Henry Joshua,Elbert E. Harris,Arthur A. Patchett,R L Monaghan,S Currie,E Stapley,George Albers-Schonberg,Otto D. Hensens,J Hirshfield,Karst Hoogsteen,Jerrold M. Liesch,James P. Springer +19 more
TL;DR: It was shown that mevinolin was an orally active cholesterol-lowering agent in the dog and orally administered sodium mevinolinate was an active inhibitor of cholesterol synthesis in an acute assay.
Journal ArticleDOI
Ml-236a, ml-236b, and ml-236c, new inhibitors of cholesterogenesis produced by penicillium citrinum
Journal ArticleDOI
Competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme a reductase by ML-236A and ML-236B fungal metabolites, having hypocholesterolemic activity
TL;DR: The experiments reported in this paper demonstrate that MG236A and ML-236B inhibit specifically 3-hydroxy-3-methylglutaryl (HMG)CoA reductase (EC 1 .I .1.34), the rate-limiting enzyme in cholesterol synthetic pathway, without affecting the rest of the enzymes involved in this pathway, and that the inhibition is competitive with respect to the substrate HMG-CoA.
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Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.
Alfred W. Alberts,Julie S. Chen,G Kuron,V Hunt,Jesse W. Huff,Carl H. Hoffman,John W. Rothrock,Lopez Maria B,Henry Joshua,Elbert E. Harris,Arthur A. Patchett,R L Monaghan,S Currie,E Stapley,George Albers-Schonberg,Otto D. Hensens,J Hirshfield,Karst Hoogsteen,Jerrold M. Liesch,James P. Springer +19 more