Resveratrol Reduces Radiation-Induced Chromosome Aberration Frequencies in Mouse Bone Marrow Cells

TLDR: This study is the first to demonstrate that resveratrol has radioprotective effects in vivo, and support the use of resver atrol as a radioprotsector with the potential for widespread application.

Abstract: Carsten, R. E., Bachand, A. M., Bailey, S. M. and Ullrich, R. L. Resveratrol Reduces Radiation-Induced Chromosome Aberration Frequency in Mouse Bone Marrow Cells. Radiat. Res. 169, 633–638 (2008). Resveratrol, a polyphenol compound with reported antioxidant and anticarcinogenic effects, a wide range of molecular targets, and toxicity only at extreme doses, has received considerable attention. We evaluated the radioprotective effect of orally administered resveratrol on the frequencies of chromosome aberrations in irradiated mouse bone marrow cells. CBA/CaJ mice were divided into four groups: (1) no treatment, (2) resveratrol only, (3) radiation only, and (4) resveratrol and radiation. Resveratrol treatment (100 mg/kg daily) was initiated 2 days prior to irradiation. Bone marrow was then harvested at 1 and 30 days after a single dose of 3 Gy whole-body γ radiation. A statistically significant (P < 0.05) reduction in the mean total chromosome aberration frequency per metaphase at both times postirr...