Review of optical breast imaging and spectroscopy
TLDR
The clinical results on functional properties of malignant and benign breast lesions compared to host tissue are reviewed and the various methods to improve contrast between healthy and diseased tissue are discussed, such as enhanced spectroscopic information, dynamic variations of functional properties, and pharmacokinetics of extrinsic contrast agents.Abstract:
Diffuse optical imaging and spectroscopy of the female breast is an area of active research. We review the present status of this field and discuss the broad range of methodologies and applications. Starting with a brief overview on breast physiology, the remodeling of vasculature and extracellular matrix caused by solid tumors is highlighted that is relevant for contrast in optical imaging. Then, the various instrumental techniques and the related methods of data analysis and image generation are described and compared including multimodality instrumentation, fluorescence mammography, broadband spectroscopy, and diffuse correlation spectroscopy. We review the clinical results on functional properties of malignant and benign breast lesions compared to host tissue and discuss the various methods to improve contrast between healthy and diseased tissue, such as enhanced spectroscopic information, dynamic variations of functional properties, pharmacokinetics of extrinsic contrast agents, including the enhanced permeability and retention effect. We discuss research on monitoring neoadjuvant chemotherapy and on breast cancer risk assessment as potential clinical applications of optical breast imaging and spectroscopy. Moreover, we consider new experimental approaches, such as photoacoustic imaging and long-wavelength tissue spectroscopy.read more
Citations
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Journal ArticleDOI
Multispectral Optoacoustic Tomography (MSOT) of Human Breast Cancer.
Gael Diot,Stephan Metz,Aurelia Noske,Evangelos Liapis,Barbara Schroeder,Saak V. Ovsepian,Reinhard Meier,Ernst J. Rummeny,Vasilis Ntziachristos +8 more
TL;DR: Fast handheld multispectral optoacoustic tomography of the breast at 28 wavelengths resolves physiologic cancer features with high resolution and revealed patterns not offered by other radiologic modalities.
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New frontiers in time-domain diffuse optics, a review
Antonio Pifferi,Antonio Pifferi,Davide Contini,Alberto Dalla Mora,Andrea Farina,Lorenzo Spinelli,Alessandro Torricelli,Alessandro Torricelli +7 more
TL;DR: This study shows how these tools could lead on one hand to compact and wearable time-domain devices for point-of-care diagnostics down to the consumer level and on the other hand to powerful systems with exceptional depth penetration and sensitivity.
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Measurement of tissue optical properties in the context of tissue optical clearing
Alexey N. Bashkatov,K. V. Berezin,Konstantin N. Dvoretskiy,Maria L. Chernavina,Elina A. Genina,Elina A. Genina,Vadim D. Genin,V. I. Kochubey,V. I. Kochubey,Ekaterina N. Lazareva,Ekaterina N. Lazareva,Ekaterina N. Lazareva,Alexander B. Pravdin,Marina E. Shvachkina,Polina A. Timoshina,Polina A. Timoshina,Daria K. Tuchina,Daria K. Tuchina,Dmitry D. Yakovlev,Dmitry A. Yakovlev,Irina Yu. Yanina,Irina Yu. Yanina,Olga S. Zhernovaya,Valery V. Tuchin,Valery V. Tuchin,Valery V. Tuchin +25 more
TL;DR: An overview of recent results on the measurements and control of tissue optical properties is presented, including a brief review of optical properties of biological tissues and efficacy of optical clearing method in application to monitoring of diabetic complications and visualization of blood vessels and microcirculation.
Journal ArticleDOI
Clinical Brain Monitoring with Time Domain NIRS: A Review and Future Perspectives
Frédéric Lange,Ilias Tachtsidis +1 more
TL;DR: A review of brain monitoring clinical applications of TD-NIRS, spanning the fields of neonatal imaging, stroke assessment, traumatic brain injury (TBI) assessment, brain death assessment, psychiatry, peroperative care, neuronal disorders assessment and communication with patient with locked-in syndrome.
Journal ArticleDOI
Multispectral optoacoustic tomography of the human breast: characterisation of healthy tissue and malignant lesions using a hybrid ultrasound-optoacoustic approach.
A Becker,Max Masthoff,Jing Claussen,Steven James Ford,Wolfgang Roll,Matthias C. Burg,Peter J Barth,Walter Heindel,Michael Schäfers,Michel Eisenblätter,Moritz Wildgruber +10 more
TL;DR: This preliminary MSOT breast imaging study provided stable, reproducible data on tissue composition and physiological properties, potentially enabling differentiation of solid malignant and healthy tissue.
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