Review of the Current Management of Pressure Ulcers.
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TLDR
Despite an increased number of therapies available on the market, none has demonstrated any clear benefit over the others and pressure ulcer treatment remains frustrating and time-consuming.Abstract:
Significance: The incidence of pressure ulcers is increasing due to our aging population and the increase in the elderly living with disability. Learning how to manage pressure ulcers appropriately is increasingly important for all professionals in wound care. Recent Advances: Many new dressings and treatment modalities have been developed over the recent years and the goal of this review is to highlight their benefits and drawbacks to help providers choose their tools appropriately. Critical Issues: Despite an increased number of therapies available on the market, none has demonstrated any clear benefit over the others and pressure ulcer treatment remains frustrating and time-consuming. Future Directions: Additional research is needed to develop products more effective in prevention and treatment of pressure ulcers.read more
Citations
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Nanomaterials for Wound Dressings: An Up-to-Date Overview.
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Infections in the Elderly Critically-Ill Patients.
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Race Based Medicine, Colorblind Disease: How Racism in Medicine Harms Us All.
TL;DR: How the continued misuse of race in medicine and the identification of Whites as the control group, which reinforces this racial hierarchy, are examples of racism in medicine that harm all us is discussed.
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Biofilm-Innate Immune Interface: Contribution to Chronic Wound Formation.
Zoya Versey,Waleska Stephanie da Cruz Nizer,Emily Russell,Sandra Zigic,Katrina G. DeZeeuw,Jonah E. Marek,Joerg Overhage,Edana Cassol,Edana Cassol +8 more
TL;DR: In this paper, the authors discuss the current literature on how bacterial populations and biofilms contribute to chronic wound formation, the role of bacteria and bio-films in driving dysfunctional innate immune responses in chronic wounds, and therapeutics currently available (or underdevelopment) that target bacteria-innate immune interactions to improve healing.
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Chronic wounds: Treatment consensus
Elof Erik Eriksson,Paul Y. Liu,Gregory S. Schultz,Manuela Martins-Green,Rica Tanaka,Dot Weir,Lisa J. Gould,David G. Armstrong,Gary H. Gibbons,R.D. Wolcott,Oluyinka O. Olutoye,Robert S. Kirsner,Geoffrey C. Gurtner +12 more
TL;DR: A panel of 13 experts were invited to a virtual meeting which took place on 27 March 2021, and important takeaways included that wound care needs to be simplified to a point that it can be delivered by the patient or the patient's family.
References
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Support surfaces for pressure ulcer prevention
Elizabeth McInnes,Asmara Jammali-Blasi,Sally E. M. Bell-Syer,Jo C Dumville,Victoria Middleton,Nicola Cullum +5 more
TL;DR: The extent to which pressure-relieving support surfaces reduce the incidence of pressure ulcers compared with standard support surfaces is established, and their comparative effectiveness in ulcer prevention is established.
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Pressure Ulcers in the Nursing Home
TL;DR: There is now consensus on the use of the term pressure ulcer rather than synonyms such as decubitus ulcer or bed sore, and four ulcer stages are useful for reporting prevalence and guiding therapy in the nursing home population.
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The impact of the aging population on coronary heart disease in the United States.
Michelle C. Odden,Pamela G. Coxson,Andrew E. Moran,Andrew E. Moran,James Lightwood,Lee Goldman,Kirsten Bibbins-Domingo +6 more
TL;DR: The aging of the US population will result in a sizeable increase in coronary heart disease incidence, prevalence, mortality, and costs, which may be possible to offset through achievement of Healthy People 2010/2020 objectives or interventions that substantially reduce obesity, blood pressure, or cholesterol levels in the population.
Journal Article
Pressure ulcers: prevention, evaluation, and management.
Daniel Bluestein,Ashkan Javaheri +1 more
TL;DR: Treatment involves management of local and distant infections, removal of necrotic tissue, maintenance of a moist environment for wound healing, and possibly surgery, and systemic antibiotics are used in patients with advancing cellulitis, osteomyelitis, or systemic infection.
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Cytotoxicity mechanisms of sodium hypochlorite in cultured human dermal fibroblasts and its bactericidal effectiveness
TL;DR: Hypochlorous acid proved to exert a rapid inhibitory effect on DNA synthesis, consistent with its primary role in bacterial killing by phagocytes, and Cytotoxicity produced by increasing NaOCl concentrations and assessed by measuring both mitochondrial function and cell DNA synthesis was reduced.