Journal ArticleDOI
Risk for Malignancy of Thyroid Nodules as Assessed by Sonographic Criteria The Need for Biopsy
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TLDR
This study indicates that the presence of intrinsic microcalcification is the only statistically reliable criterion on which to base increased suspicion for malignancy in thyroid nodules, particularly if calcifications have a snowstorm appearance on sonography.Abstract:
Objective. To correlate sonographic and color Doppler characteristics of thyroid nodules with the results of sonographically guided fine-needle aspiration biopsy to establish the relative importance of these features in predicting risk for malignancy. Methods. We retrospectively analyzed the sonographic features of 34 malignant and 36 benign thyroid nodules with respect to size, echogenicity, echo structure, shape, border, calcification, and internal vascularity. Individual features and combinations of features were analyzed for their correlation with benign or malignant disease. A comparative analysis of several authors' previously proposed methods for distinguishing between benign and malignant nodules using sonographic criteria was also performed to determine their sensitivity and specificity in predicting nodule disease within our study data. Results. Nodule size ranged from 0.8 to 4.6 cm in greatest dimension (mean, 1.96 cm; SD, 0.877 cm). The prevalence of malignancy in our study population was estimated to be nearly 5.33%. Intragroup comparison of sonographic features among benign and malignant nodules resulted in identification of intrinsic calcification as the only statistically significant predictor of malignancy (35.3% sensitive and 94.4% specific; P <.005). Presence of a "snowstorm" pattern of calcification was 100% specific for malignancy. Echogenicity, echo structure, shape, border classification, and grade of internal vascularity did not show any significant difference between benign and malignant nodules in this study. Various combinations of features previously suggested to be significant predictors of malignancy were also analyzed and shown to have very little sensitivity or specificity in predicting benign or malignant disease among nodules in our study population. Conclusions. This study indicates that the presence of intrinsic microcalcification is the only statistically reliable criterion on which to base increased suspicion for malignancy in thyroid nodules. Our results indicate the need for biopsy in determining further workup. All nodules that show the presence of intrinsic microcalcification should undergo biopsy, particularly if calcifications have a snowstorm appearance on sonography.read more
Citations
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The prevalence and significance of incidental thyroid nodules identified on computed tomography.
Dae Young Yoon,Suk Ki Chang,Chul Soon Choi,Eun Joo Yun,Young Lan Seo,Eun Suk Nam,Sung Jin Cho,Young Soo Rho,Hwoe Young Ahn +8 more
TL;DR: Assessing the prevalence of incidental thyroid nodules found on computed tomography (CT) of the neck and whether CT characteristics could distinguish malignant from benign thyroid lesions found at least a 9.4% prevalence of malignancy among ITN detected on CT.
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Evaluating the degree of conformity of papillary carcinoma and follicular carcinoma to the reported ultrasonographic findings of malignant thyroid tumor.
TL;DR: The current ultrasonographic features for thyroid malignancy should be cautiously applied as the indication for needle aspiration biopsy so that follicular carcinomas are not missed by too narrow and strict biopsy criteria.
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Comparison of palpation-guided fine-needle aspiration biopsy to ultrasound-guided fine-needle aspiration biopsy in the evaluation of thyroid nodules.
Mustafa Cesur,Demet Corapcioglu,Safak Bulut,Alptekin Gursoy,Arif Ender Yilmaz,Nural Erdogan,Nuri Kamel +6 more
TL;DR: UGFNAB is considered to be superior to PGFNAB for obtaining adequate material especially for small-sized nodules, as well as providing more accurate cytologic evaluation.
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Systematic review: prevalence of malignant incidental thyroid nodules identified on fluorine-18 fluorodeoxyglucose positron emission tomography.
TL;DR: The high prevalence of malignancy associated with focal hypermetabolic thyroid nodules found on 18F-FDG-PET warrants further evaluation when detected.
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Flow Pattern and Vascular Resistive Index as Predictors of Malignancy Risk in Thyroid Follicular Neoplasms
Harley De Nicola,Jacob Szejnfeld,Ângela Flavia Logullo,Ângela Maria Borri Wolosker,Luis Ronan Marquez Ferreira de Souza,Valcir Chiferi +5 more
TL;DR: The purpose of this study was to evaluate whether flow pattern and resistive index are useful parameters for distinguishing benign from malignant thyroid follicular neoplasms (FNs).
References
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Journal ArticleDOI
Risk of malignancy in nonpalpable thyroid nodules: predictive value of ultrasound and color-Doppler features.
Enrico Papini,Rinaldo Guglielmi,Antonio Bianchini,Anna Crescenzi,Silvia Taccogna,Francesco Nardi,Claudio Panunzi,R. Rinaldi,Vincenzo Toscano,Claudio Maurizio Pacella +9 more
TL;DR: The aim of the study was to correlate the sonographic and color-Doppler findings with the results of US-guided fine needle aspiration biopsy and of pathologic staging of resected carcinomas to establish the relative importance of US features as risk factors of malignancy and a cost-effective management of nonpalpable thyroid nodules.
Journal ArticleDOI
New Sonographic Criteria for Recommending Fine-Needle Aspiration Biopsy of Nonpalpable Solid Nodules of the Thyroid
Eun Kyung Kim,Cheong Soo Park,Woung Youn Chung,Ki Keun Oh,Dong-Ik Kim,Jong Tae Lee,Hyung Sik Yoo +6 more
TL;DR: Considering the high level of sensitivity of the proposed sonographic classification, fine-needle aspiration biopsy should be performed on thyroid nodules classified as positive, regardless of palpability.
Journal ArticleDOI
Occult papillary carcinoma of the thyroid. A “normal” finding in finland. A systematic autopsy study
TL;DR: According to the study, OPC can be regarded as a normal finding which should not be treated when incidentally found and in order to avoid unnecessary operations it is suggested that incidentally found small OPCs were called occult papillary tumor instead of carcinoma.
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Thyroid Incidentalomas: Prevalence by Palpation and Ultrasonography
TL;DR: The data indicate that thyroid abnormalities are very common incidental findings, emphasizing the need for a conservative approach when such lesions are encountered incidentally.
Journal ArticleDOI
Occult Papillary Carcinoma of the Thyroid
TL;DR: Long-term follow-up showed that all patients were alive and without disease or were dead without proof of thyroid-related disease and occult papillary thyroid carcinoma with or without nodal metastasis is a nonlethal and curable disease when treated by conservative surgical means.
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