Journal ArticleDOI
Risk for Malignancy of Thyroid Nodules as Assessed by Sonographic Criteria The Need for Biopsy
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TLDR
This study indicates that the presence of intrinsic microcalcification is the only statistically reliable criterion on which to base increased suspicion for malignancy in thyroid nodules, particularly if calcifications have a snowstorm appearance on sonography.Abstract:
Objective. To correlate sonographic and color Doppler characteristics of thyroid nodules with the results of sonographically guided fine-needle aspiration biopsy to establish the relative importance of these features in predicting risk for malignancy. Methods. We retrospectively analyzed the sonographic features of 34 malignant and 36 benign thyroid nodules with respect to size, echogenicity, echo structure, shape, border, calcification, and internal vascularity. Individual features and combinations of features were analyzed for their correlation with benign or malignant disease. A comparative analysis of several authors' previously proposed methods for distinguishing between benign and malignant nodules using sonographic criteria was also performed to determine their sensitivity and specificity in predicting nodule disease within our study data. Results. Nodule size ranged from 0.8 to 4.6 cm in greatest dimension (mean, 1.96 cm; SD, 0.877 cm). The prevalence of malignancy in our study population was estimated to be nearly 5.33%. Intragroup comparison of sonographic features among benign and malignant nodules resulted in identification of intrinsic calcification as the only statistically significant predictor of malignancy (35.3% sensitive and 94.4% specific; P <.005). Presence of a "snowstorm" pattern of calcification was 100% specific for malignancy. Echogenicity, echo structure, shape, border classification, and grade of internal vascularity did not show any significant difference between benign and malignant nodules in this study. Various combinations of features previously suggested to be significant predictors of malignancy were also analyzed and shown to have very little sensitivity or specificity in predicting benign or malignant disease among nodules in our study population. Conclusions. This study indicates that the presence of intrinsic microcalcification is the only statistically reliable criterion on which to base increased suspicion for malignancy in thyroid nodules. Our results indicate the need for biopsy in determining further workup. All nodules that show the presence of intrinsic microcalcification should undergo biopsy, particularly if calcifications have a snowstorm appearance on sonography.read more
Citations
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Solid and isoechoic thyroid nodules without malignant sonographic features: comparison of malignancy rate according to nodule size, shape and color Doppler pattern.
TL;DR: A significant relationship between peripheral vascularity of SITNs and benignity was found but the other vascularity patterns showed no significant association with malignancy or benignity.
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Role of 99mTc-Tetrofosmin delayed scintigraphy and color Doppler sonography in characterization of solitary thyroid nodules.
Rajnish Sharma,Kanti Lal Chakravarty,Madhvi Tripathi,Aruna Kaushik,Pooja Bharti,Maheswar Sahoo,Mahender Kumar Chopra,Harish Rawat,Anil Misra,Anupam Mondal,Ravi Kashyap +10 more
TL;DR: Delayed 99mTc-Tetrofosmin scintigraphy is a highly sensitive and specific method for characterizing solitary thyroid nodules, while color Doppler has a low sensitivity but relatively high specificity in differentiating benign from malignant thyroid lesions.
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Elastography for the diagnosis of high-suspicion thyroid nodules based on the 2015 American Thyroid Association guidelines: a multicenter study
Li Hairu,Peng Yu-lan,Wang Yan,Ai Hong,Zhou Xiaodong,Yang Lichun,Yan Kun,Xiao Ying,Liu Lisha,Luo Bao-ming,Yong Qiang,Cong Shuzhen,Jiang Shuang-quan,Fu Xin,Ma Buyun,Li Yi,Zhang Xixi,Gong Xue,Chen Haitao,Liu Wenying,Tang Ling,Lv Xiaoyu,Zhao Xinbao,Li Liang,Gan Kehong,Tian Jiawei +25 more
TL;DR: Elastography combined with the ES is a valuable tool for the assessment of high-suspicion thyroid nodules based on the 2015 ATA guidelines, especially in nodules ≥1 cm, where the sensitivity, specificity, accuracy, positive predictive value (PPV), accuracy and NPV of the ES were all superior.
Journal ArticleDOI
A Novel Interpretable Computer-Aided Diagnosis System of Thyroid Nodules on Ultrasound Based on Clinical Experience
Shijie Zhang,Huarui Du,Zhuang Jin,Yaqiong Zhu,Ying Zhang,Fang Xie,Ming-bo Zhang,Xiaoqi Tian,Jue Zhang,Luo Yukun +9 more
TL;DR: An interpretable CADs (iCADS) is developed that utilizes deep-learning networks’ classification power and interpretability potential of clinical guidelines, like TIRADS, a well-established scale for thyroid nodules.
Journal ArticleDOI
CT-detected solitary thyroid calcification: an important imaging feature for papillary carcinoma.
TL;DR: Solitary calcified thyroid nodules detected on CT represent a high risk for papillary thyroid carcinoma, especially when the size of the lesions increases after contrast- enhanced CT.
References
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TL;DR: Considering the high level of sensitivity of the proposed sonographic classification, fine-needle aspiration biopsy should be performed on thyroid nodules classified as positive, regardless of palpability.
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Occult Papillary Carcinoma of the Thyroid
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