Journal ArticleDOI
Risk for Malignancy of Thyroid Nodules as Assessed by Sonographic Criteria The Need for Biopsy
Reads0
Chats0
TLDR
This study indicates that the presence of intrinsic microcalcification is the only statistically reliable criterion on which to base increased suspicion for malignancy in thyroid nodules, particularly if calcifications have a snowstorm appearance on sonography.Abstract:
Objective. To correlate sonographic and color Doppler characteristics of thyroid nodules with the results of sonographically guided fine-needle aspiration biopsy to establish the relative importance of these features in predicting risk for malignancy. Methods. We retrospectively analyzed the sonographic features of 34 malignant and 36 benign thyroid nodules with respect to size, echogenicity, echo structure, shape, border, calcification, and internal vascularity. Individual features and combinations of features were analyzed for their correlation with benign or malignant disease. A comparative analysis of several authors' previously proposed methods for distinguishing between benign and malignant nodules using sonographic criteria was also performed to determine their sensitivity and specificity in predicting nodule disease within our study data. Results. Nodule size ranged from 0.8 to 4.6 cm in greatest dimension (mean, 1.96 cm; SD, 0.877 cm). The prevalence of malignancy in our study population was estimated to be nearly 5.33%. Intragroup comparison of sonographic features among benign and malignant nodules resulted in identification of intrinsic calcification as the only statistically significant predictor of malignancy (35.3% sensitive and 94.4% specific; P <.005). Presence of a "snowstorm" pattern of calcification was 100% specific for malignancy. Echogenicity, echo structure, shape, border classification, and grade of internal vascularity did not show any significant difference between benign and malignant nodules in this study. Various combinations of features previously suggested to be significant predictors of malignancy were also analyzed and shown to have very little sensitivity or specificity in predicting benign or malignant disease among nodules in our study population. Conclusions. This study indicates that the presence of intrinsic microcalcification is the only statistically reliable criterion on which to base increased suspicion for malignancy in thyroid nodules. Our results indicate the need for biopsy in determining further workup. All nodules that show the presence of intrinsic microcalcification should undergo biopsy, particularly if calcifications have a snowstorm appearance on sonography.read more
Citations
More filters
Journal ArticleDOI
US, colour-Doppler US and fine-needle aspiration biopsy in the diagnosis of thyroid nodules
Fulvio Stacul,Michele Bertolotto,F. De Gobbis,L. Calderan,Vincenzo Cioffi,A. Romano,Fabrizio Zanconati,Maria Assunta Cova +7 more
TL;DR: Thyroid nodules cannot be accurately characterised using grey-scale US or colour-Doppler US because of a slight increase in sensitivity but a slight reduction in specificity.
Journal ArticleDOI
Imaging for staging and management of thyroid cancer
TL;DR: This review focuses on how imaging now influences the staging and management of the primary cancer, nodal metastases and distant metastases, and the role of imaging in planning post-operative radiotherapy and post-treatment surveillance.
Journal ArticleDOI
Ex vivo imaging of human thyroid pathology using integrated optical coherence tomography and optical coherence microscopy.
Chao Zhou,Yihong Wang,Aaron D. Aguirre,Tsung-Han Tsai,David W. Cohen,James L. Connolly,James G. Fujimoto +6 more
TL;DR: Characteristic features that suggest malignant lesions, such as complex papillary architecture, microfollicules, psammomatous calcifications, or replacement of normal follicular architecture with sheets/nests of tumor cells, can be identified and are clearly differentiable from normal or benign thyroid tissues.
Journal ArticleDOI
Computer-aided diagnosis of malignant or benign thyroid nodes based on ultrasound images
TL;DR: Both ANN and SVM had high value in classifying thyroid nodes and in combination, the sensitivity increased but specificity decreased; this combination might provide a second opinion for radiologists dealing with difficult to diagnose thyroid node ultrasound images.
Journal ArticleDOI
Gray-scale and color Doppler ultrasonographic manifestations of papillary thyroid carcinoma: analysis of 51 cases.
Wei-Hsin Yuan,Hong-Jen Chiou,Hong-Jen Chiou,Yi-Hong Chou,Yi-Hong Chou,Hui-Chen Hsu,Chui-Mei Tiu,Chui-Mei Tiu,Chang-Yen Cheng,Chang-Yen Cheng,Chen-Hsen Lee,Chen-Hsen Lee +11 more
TL;DR: All lesions in this series had a predominantly solid characteristic on gray-scale US and features such as predominantly cystic composition, hyperechoic texture, and hypoechoic halo with even thickness were never found in this study.
References
More filters
Journal ArticleDOI
Risk of malignancy in nonpalpable thyroid nodules: predictive value of ultrasound and color-Doppler features.
Enrico Papini,Rinaldo Guglielmi,Antonio Bianchini,Anna Crescenzi,Silvia Taccogna,Francesco Nardi,Claudio Panunzi,R. Rinaldi,Vincenzo Toscano,Claudio Maurizio Pacella +9 more
TL;DR: The aim of the study was to correlate the sonographic and color-Doppler findings with the results of US-guided fine needle aspiration biopsy and of pathologic staging of resected carcinomas to establish the relative importance of US features as risk factors of malignancy and a cost-effective management of nonpalpable thyroid nodules.
Journal ArticleDOI
New Sonographic Criteria for Recommending Fine-Needle Aspiration Biopsy of Nonpalpable Solid Nodules of the Thyroid
Eun Kyung Kim,Cheong Soo Park,Woung Youn Chung,Ki Keun Oh,Dong-Ik Kim,Jong Tae Lee,Hyung Sik Yoo +6 more
TL;DR: Considering the high level of sensitivity of the proposed sonographic classification, fine-needle aspiration biopsy should be performed on thyroid nodules classified as positive, regardless of palpability.
Journal ArticleDOI
Occult papillary carcinoma of the thyroid. A “normal” finding in finland. A systematic autopsy study
TL;DR: According to the study, OPC can be regarded as a normal finding which should not be treated when incidentally found and in order to avoid unnecessary operations it is suggested that incidentally found small OPCs were called occult papillary tumor instead of carcinoma.
Journal ArticleDOI
Thyroid Incidentalomas: Prevalence by Palpation and Ultrasonography
TL;DR: The data indicate that thyroid abnormalities are very common incidental findings, emphasizing the need for a conservative approach when such lesions are encountered incidentally.
Journal ArticleDOI
Occult Papillary Carcinoma of the Thyroid
TL;DR: Long-term follow-up showed that all patients were alive and without disease or were dead without proof of thyroid-related disease and occult papillary thyroid carcinoma with or without nodal metastasis is a nonlethal and curable disease when treated by conservative surgical means.
Related Papers (5)
Management of thyroid nodules detected at US: Society of radiologists in ultrasound consensus conference statement
Mary C. Frates,Carol B. Benson,J. William Charboneau,Edmund S. Cibas,Orlo H. Clark,Beverly G. Coleman,John J. Cronan,Peter M. Doubilet,Douglas B. Evans,John R. Goellner,Ian D. Hay,Barbara S. Hertzberg,Charles M. Intenzo,R. Brooke Jeffrey,Jill E. Langer,P. Reed Larsen,Susan J. Mandel,William D. Middleton,Carl C. Reading,Steven I. Sherman,Franklin N. Tessler +20 more