Journal ArticleDOI
Risk for Malignancy of Thyroid Nodules as Assessed by Sonographic Criteria The Need for Biopsy
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TLDR
This study indicates that the presence of intrinsic microcalcification is the only statistically reliable criterion on which to base increased suspicion for malignancy in thyroid nodules, particularly if calcifications have a snowstorm appearance on sonography.Abstract:
Objective. To correlate sonographic and color Doppler characteristics of thyroid nodules with the results of sonographically guided fine-needle aspiration biopsy to establish the relative importance of these features in predicting risk for malignancy. Methods. We retrospectively analyzed the sonographic features of 34 malignant and 36 benign thyroid nodules with respect to size, echogenicity, echo structure, shape, border, calcification, and internal vascularity. Individual features and combinations of features were analyzed for their correlation with benign or malignant disease. A comparative analysis of several authors' previously proposed methods for distinguishing between benign and malignant nodules using sonographic criteria was also performed to determine their sensitivity and specificity in predicting nodule disease within our study data. Results. Nodule size ranged from 0.8 to 4.6 cm in greatest dimension (mean, 1.96 cm; SD, 0.877 cm). The prevalence of malignancy in our study population was estimated to be nearly 5.33%. Intragroup comparison of sonographic features among benign and malignant nodules resulted in identification of intrinsic calcification as the only statistically significant predictor of malignancy (35.3% sensitive and 94.4% specific; P <.005). Presence of a "snowstorm" pattern of calcification was 100% specific for malignancy. Echogenicity, echo structure, shape, border classification, and grade of internal vascularity did not show any significant difference between benign and malignant nodules in this study. Various combinations of features previously suggested to be significant predictors of malignancy were also analyzed and shown to have very little sensitivity or specificity in predicting benign or malignant disease among nodules in our study population. Conclusions. This study indicates that the presence of intrinsic microcalcification is the only statistically reliable criterion on which to base increased suspicion for malignancy in thyroid nodules. Our results indicate the need for biopsy in determining further workup. All nodules that show the presence of intrinsic microcalcification should undergo biopsy, particularly if calcifications have a snowstorm appearance on sonography.read more
Citations
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Journal ArticleDOI
The Validity of Ultrasonography-Guided Fine Needle Aspiration Biopsy in Thyroid Nodules 4 cm or Larger Depends on Ultrasonography Characteristics
Jin Hwa Kim,Na Kyung Kim,Young Lyun Oh,Hye Jeong Kim,Sang Yong Kim,Jae Hoon Chung,Sun Wook Kim +6 more
TL;DR: The validity of fine needle aspiration biopsy according to ultrasonography (US) characteristics in thyroid nodules 4 cm and larger is evaluated and individualized strategies for large thyroid nodule according to US features are suggested.
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Nodule size and fine-needle aspiration biopsy: diagnostic challenges for thyroid malignancy.
Stefano Rausei,Gianlorenzo Dionigi,Francesco Frattini,Patrizia Castano,Andrea Leotta,Francesca Rovera,Luigi Boni,Luigi Bartalena,Renzo Dionigi +8 more
TL;DR: Nodule size does not appear to be a reliable parameter to improve the clinical management of a nodular goiter because of a high variability between size of nodular area and tumor diameter.
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Update on thyroid ultrasound: a narrative review from diagnostic criteria to artificial intelligence techniques.
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TL;DR: The vascularity type of "focal thyroid inferno" is specific for focal Hashimoto thyroiditis and recognition of this particular feature may avoid unnecessary interventional procedures for some solid hypoechoic thyroid nodules suspicious of malignancy.
References
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Journal ArticleDOI
Risk of malignancy in nonpalpable thyroid nodules: predictive value of ultrasound and color-Doppler features.
Enrico Papini,Rinaldo Guglielmi,Antonio Bianchini,Anna Crescenzi,Silvia Taccogna,Francesco Nardi,Claudio Panunzi,R. Rinaldi,Vincenzo Toscano,Claudio Maurizio Pacella +9 more
TL;DR: The aim of the study was to correlate the sonographic and color-Doppler findings with the results of US-guided fine needle aspiration biopsy and of pathologic staging of resected carcinomas to establish the relative importance of US features as risk factors of malignancy and a cost-effective management of nonpalpable thyroid nodules.
Journal ArticleDOI
New Sonographic Criteria for Recommending Fine-Needle Aspiration Biopsy of Nonpalpable Solid Nodules of the Thyroid
Eun Kyung Kim,Cheong Soo Park,Woung Youn Chung,Ki Keun Oh,Dong-Ik Kim,Jong Tae Lee,Hyung Sik Yoo +6 more
TL;DR: Considering the high level of sensitivity of the proposed sonographic classification, fine-needle aspiration biopsy should be performed on thyroid nodules classified as positive, regardless of palpability.
Journal ArticleDOI
Occult papillary carcinoma of the thyroid. A “normal” finding in finland. A systematic autopsy study
TL;DR: According to the study, OPC can be regarded as a normal finding which should not be treated when incidentally found and in order to avoid unnecessary operations it is suggested that incidentally found small OPCs were called occult papillary tumor instead of carcinoma.
Journal ArticleDOI
Thyroid Incidentalomas: Prevalence by Palpation and Ultrasonography
TL;DR: The data indicate that thyroid abnormalities are very common incidental findings, emphasizing the need for a conservative approach when such lesions are encountered incidentally.
Journal ArticleDOI
Occult Papillary Carcinoma of the Thyroid
TL;DR: Long-term follow-up showed that all patients were alive and without disease or were dead without proof of thyroid-related disease and occult papillary thyroid carcinoma with or without nodal metastasis is a nonlethal and curable disease when treated by conservative surgical means.
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