Journal ArticleDOI
Rituximab for induction and maintenance therapy in granulomatosis with polyangiitis (Wegener's). Results of a single-center cohort study on 66 patients.
Ana Luisa Calich,Xavier Puéchal,Xavier Puéchal,Grégory Pugnet,Jonathan London,Benjamin Terrier,Pierre Charles,Luc Mouthon,Loïc Guillevin +8 more
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TLDR
It is concluded that in this single-center cohort, RTX associated with glucocorticoid treatment adapted for disease severity appeared to induce remission effectively in GPA patients, and maintenance treatment with low doses of RTX in a routine time-based protocol was safe and associated with low rates of relapse on treatment.About:
This article is published in Journal of Autoimmunity.The article was published on 2014-05-01. It has received 71 citations till now. The article focuses on the topics: Maintenance therapy & Granulomatosis with polyangiitis.read more
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The diagnosis and clinical management of the catastrophic antiphospholipid syndrome: A comprehensive review.
TL;DR: Treatment is based on the administration of anticoagulants, corticosteroids, plasma exchange and/or intravenous immunoglobulins in patients with CAPS, and Cyclophosphamide is recommended in those CAPS cases associated to systemic lupus erythematosus.
Journal ArticleDOI
B-Lymphocyte Depletion in Myalgic Encephalopathy/ Chronic Fatigue Syndrome. An Open-Label Phase II Study with Rituximab Maintenance Treatment.
Øystein Fluge,Kristin Risa,Sigrid Lunde,Kine Alme,Ingrid Gurvin Rekeland,Dipak Sapkota,Einar Kleboe Kristoffersen,Kari Sørland,Ove Bruland,Olav Dahl,Olav Mella +10 more
TL;DR: The observed patterns of delayed responses and relapse after B-cell depletion and regeneration, a three times higher disease prevalence in women than in men, and a previously demonstrated increase in B- cell lymphoma risk for elderly ME/CFS patients, suggest that ME/ CFS may be a variant of an autoimmune disease.
Journal ArticleDOI
Opportunistic infections and biologic therapies in immune-mediated inflammatory diseases: consensus recommendations for infection reporting during clinical trials and postmarketing surveillance
Kevin L. Winthrop,Shannon A. Novosad,John W. Baddley,L. Calabrese,Tom Chiller,Philip M. Polgreen,F Bartalesi,Marc Lipman,Xavier Mariette,Olivier Lortholary,Michael E. Weinblatt,Michael S. Saag,Josef S Smolen +12 more
TL;DR: The consensus group developed a working definition for OIs as ‘indicator’ infections, defined as specific pathogens or presentations of pathogens that ’indicate’ the likelihood of an alteration in host immunity in the setting of biologic therapy.
Journal ArticleDOI
Trimethoprim–sulfamethoxazole prophylaxis prevents severe/life-threatening infections following rituximab in antineutrophil cytoplasm antibody-associated vasculitis
Andreas Kronbichler,Julia Kerschbaum,Seerapani Gopaluni,Joanna Tieu,Federico Alberici,Rachel B Jones,Rona M Smith,David Jayne +7 more
TL;DR: Trimethoprim–sulfamethoxazole prophylaxis reduced the risk, while especially bronchiectasis and endobronchial involvement are risk factors for severe respiratory infections, in patients with AAV receiving rituximab.
Journal ArticleDOI
Rituximab as therapy to induce remission after relapse in ANCA-associated vasculitis.
Rona M Smith,Rona M Smith,Rachel B Jones,Ulrich Specks,Simon Bond,Marianna Nodale,Reem Al-Jayyousi,J. Andrews,Annette Bruchfeld,Brian Camilleri,Simon Carette,Chee Kay Cheung,Vimal K. Derebail,Tim Doulton,Lindsy J. Forbess,Shouichi Fujimoto,Shunsuke Furuta,Ora Gewurz-Singer,Lorraine Harper,Toshiko Ito-Ihara,Nader Khalidi,Rainer Klocke,Curry L. Koening,Yoshinori Komagata,Carol A. Langford,Peter Lanyon,Raashid Luqmani,Hirofumi Makino,Carole McAlear,Paul A. Monach,Larry W. Moreland,Kim Mynard,Patrick H. Nachman,Christian Pagnoux,Fiona A Pearce,Chen Au Peh,Charles D. Pusey,Dwarakanathan Ranganathan,Rennie L. Rhee,Robert Spiera,Antoine G. Sreih,Vladimir Tesar,Giles Walters,Michael H. Weisman,Caroline Wroe,Peter A. Merkel,David Jayne,David Jayne +47 more
TL;DR: This large prospective cohort of patients with relapsing AAV treated with rituximab in conjunction with glucocorticoids demonstrated a high level of efficacy for the reinduction of remission in patients with AAV who have relapsed, with a similar safety profile to previous studies.
References
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Journal ArticleDOI
2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides
John Charles Jennette,Ronald Falk,P. A. Bacon,Neil Basu,Maria C. Cid,Franco Ferrario,Luis Felipe Flores-Suárez,W. L. Gross,Loïc Guillevin,E. C. Hagen,Gary S. Hoffman,David Jayne,Cees G. M. Kallenberg,Peter Lamprecht,Carol A. Langford,Raashid Luqmani,Alfred Mahr,Eric L. Matteson,Peter A. Merkel,Peter A. Merkel,Seza Ozen,Charles D. Pusey,Niels Rasmussen,Andrew J. Rees,David G. I. Scott,Ulrich Specks,John H. Stone,Kei Takahashi,Richard A. Watts +28 more
TL;DR: 2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides J. Watts; Arthritis & Rheumatism
2012 Revised International Chapel Hill Consensus Conference Nomenclature of
John Charles Jennette,Ronald Falk,Neil Basu,Maria C. Cid,Franco Ferrario,Luis Felipe Flores-Suárez,W. L. Gross,Loïc Guillevin,E. C. Hagen,Peter Lamprecht,Raashid Luqmani,Seza Ozen,Andrew J. Rees,Scott Dgi,Ulrich Specks,Kei Takahashi,Richard A. Watts +16 more
TL;DR: In this article, the running head is assigned to one of the following candidates:Jennette JC, Falk RJ, Bacon PA, Basu N, Cid MC, Ferrario F, Ferrardo F, Flores-Suarez LF, Gross WL, Guillevin L, Hagen EC, Hoffman GS, Jayne DR, Kallenberg CGM, Lamprecht P, Langford CA, Luqmani RA, Mahr AD, Matteson EL, Merkel PA, Ozen S, Pusey CD, Rasmussen N, Rees
Journal ArticleDOI
Wegener granulomatosis : an analysis of 158 patients
Gary S. Hoffman,Gail S. Kerr,Randi Y. Leavitt,Claire W. Hallahan,Robert S. Lebovics,William D. Travis,Menachem Rottem,Anthony S. Fauci +7 more
TL;DR: The course of Wegener granulomatosis has been dramatically improved by daily treatment with cyclophosphamide and glucocorticoids, and has led to increasing concerns about toxicity resulting from prolonged cycloph phosphamide therapy and has encouraged investigation of other therapeutic regimens.
Journal ArticleDOI
Rituximab versus Cyclophosphamide for ANCA-Associated Vasculitis
John H. Stone,Peter A. Merkel,Robert Spiera,Philip Seo,Carol A. Langford,Gary S. Hoffman,Cees G. M. Kallenberg,E. William St. Clair,Anthony M. Turkiewicz,Nadia K. Tchao,Lisa Webber,Linna Ding,Lourdes P. Sejismundo,Kathleen Mieras,David Weitzenkamp,David Ikle,Vicki Seyfert-Margolis,Mark Mueller,Paul Brunetta,Nancy B. Allen,Fernando C. Fervenza,Duvuru Geetha,Karina A. Keogh,Eugene Y. Kissin,Paul A. Monach,Tobias Peikert,Coen A. Stegeman,Steven R. Ytterberg,Ulrich Specks +28 more
TL;DR: Rituximab therapy was not inferior to daily cyclophosphamide treatment for induction of remission in severe ANCA-associated vasculitis and may be superior in relapsing disease.
Journal ArticleDOI
Wegener's granulomatosis: Prospective clinical and therapeutic experience with 85 patients for 21 years
TL;DR: It is shown that long-term remissions can be induced and maintained in an extremely high number of patients by the combination of daily cyclophosphamide and alternate-day prednisone therapy.
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Rituximab versus Cyclophosphamide for ANCA-Associated Vasculitis
John H. Stone,Peter A. Merkel,Robert Spiera,Philip Seo,Carol A. Langford,Gary S. Hoffman,Cees G. M. Kallenberg,E. William St. Clair,Anthony M. Turkiewicz,Nadia K. Tchao,Lisa Webber,Linna Ding,Lourdes P. Sejismundo,Kathleen Mieras,David Weitzenkamp,David Ikle,Vicki Seyfert-Margolis,Mark Mueller,Paul Brunetta,Nancy B. Allen,Fernando C. Fervenza,Duvuru Geetha,Karina A. Keogh,Eugene Y. Kissin,Paul A. Monach,Tobias Peikert,Coen A. Stegeman,Steven R. Ytterberg,Ulrich Specks +28 more
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Efficacy of Remission-Induction Regimens for ANCA-associated Vasculitis
Ulrich Specks,Peter A. Merkel,Philip Seo,Robert Spiera,Carol A. Langford,Gary S. Hoffman,Cees G. M. Kallenberg,E. William St. Clair,Barri J. Fessler,Linna Ding,Lisa Viviano,Nadia K. Tchao,Deborah Phippard,Adam Asare,Noha Lim,David Ikle,Brett Jepson,Paul Brunetta,Nancy B. Allen,Fernando C. Fervenza,Duvuru Geetha,Karina A. Keogh,Eugene Y. Kissin,Paul A. Monach,Tobias Peikert,Coen A. Stegeman,Steven R. Ytterberg,Mark Mueller,Lourdes P. Sejismundo,Kathleen Mieras,John H. Stone +30 more