Journal ArticleDOI
Role of 4-hydroxy-2-nonenal (HNE) in the pathogenesis of alzheimer disease and other selected age-related neurodegenerative disorders.
TLDR
HNE levels are increased in brain and body fluids of AD, PD, HD and ALS pathology, which contributes to brain damage and loss of cognitive performance, and HNE‐modified proteins may be good therapeutic targets for these diseases.About:
This article is published in Free Radical Biology and Medicine.The article was published on 2017-10-01. It has received 172 citations till now. The article focuses on the topics: Membrane permeability & Cognitive decline.read more
Citations
More filters
Journal ArticleDOI
Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease
Brent R. Stockwell,José Pedro Friedmann Angeli,Hülya Bayır,Ashley I. Bush,Marcus Conrad,Scott J. Dixon,Simone Fulda,Susan Gascon,Stavroula K. Hatzios,Valerian E. Kagan,Kay Noel,Xuejun Jiang,Andreas Linkermann,Maureen E. Murphy,Michael Overholtzer,Atsushi Oyagi,Gabriela Carolina Pagnussat,Jason Park,Qitao Ran,Craig S. Rosenfeld,Konstantin Salnikow,Daolin Tang,Daolin Tang,Frank M. Torti,Suzy V. Torti,Shinya Toyokuni,K. A. Woerpel,Donna D. Zhang +27 more
TL;DR: The mechanisms underlying ferroptosis are reviewed, connections to other areas of biology and medicine are highlighted, and tools and guidelines for studying this emerging form of regulated cell death are recommended.
Journal ArticleDOI
Oxidative stress, aging, and diseases.
Ilaria Liguori,Gennaro Russo,Francesco Curcio,Giulia Bulli,Luisa Aran,David Della-Morte,Gaetano Gargiulo,Gianluca Testa,Gianluca Testa,Francesco Cacciatore,Domenico Bonaduce,Pasquale Abete +11 more
TL;DR: Given the important role of oxidative stress in the pathogenesis of many clinical conditions and aging, antioxidant therapy could positively affect the natural history of several diseases, but further investigation is needed to evaluate the real efficacy of these therapeutic interventions.
Journal ArticleDOI
Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease
TL;DR: Current research on the interplay and sequence of oxidative damage related to impaired brain glucose metabolism and proteostasis defects are summarized and potential pharmacological interventions to retard AD progression are suggested.
Journal ArticleDOI
13 reasons why the brain is susceptible to oxidative stress.
TL;DR: 13 reasons why the brain is susceptible to oxidative stress are rationalised and key reasons include inter alia unsaturated lipid enrichment, mitochondria, calcium, glutamate, modest antioxidant defence, redox active transition metals and neurotransmitter auto-oxidation.
Journal ArticleDOI
Oxidative Stress, Amyloid-β Peptide, and Altered Key Molecular Pathways in the Pathogenesis and Progression of Alzheimer's Disease.
TL;DR: It is opine that targeting altered pathways secondary to oxidative damage in brain from persons with AD, aMCI, or Down syndrome with AD may provide strategies to slow or perhaps one day, prevent, progression or development of this devastating dementing disorder.
References
More filters
Journal ArticleDOI
Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes.
TL;DR: This review provides a comprehensive summary on the chemical properties of 4-hydroxyalkenals and malonaldehyde, the mechanisms of their formation and their occurrence in biological systems and methods for their determination, as well as the many types of biological activities described so far.
Journal ArticleDOI
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
Michael T. Lin,M. Flint Beal +1 more
TL;DR: Treatments targeting basic mitochondrial processes, such as energy metabolism or free-radical generation, or specific interactions of disease-related proteins with mitochondria hold great promise in ageing-related neurodegenerative diseases.
Book ChapterDOI
Role of free radicals and catalytic metal ions in human disease: an overview.
TL;DR: The chapter discusses the metabolism of transition metals, such as iron and copper, and the chelation therapy that is an approach to site-specific antioxidant protection.
Journal ArticleDOI
2016 Alzheimer's disease facts and figures
Journal ArticleDOI
Oxidative stress, glutamate, and neurodegenerative disorders
TL;DR: Two broad mechanisms--oxidative stress and excessive activation of glutamate receptors--are converging and represent sequential as well as interacting processes that provide a final common pathway for cell vulnerability in the brain.