Role of the coinhibitory receptor cytotoxic T lymphocyte antigen-4 on apoptosis-Prone CD8 T cells in persistent hepatitis B virus infection.
Anna Schurich,Pooja Khanna,A. Ross Lopes,Kijun Han,Dimitra Peppa,L. Micco,G. Nebbia,Patrick T F Kennedy,Anna Maria Geretti,Geoffrey Dusheiko,Mala K. Maini +10 more
TLDR
CTLA‐4 blockade could form one arm of a therapeutic approach to modulate the diverse patterns of coregulation of T‐cell exhaustion in this heterogeneous disease.About:
This article is published in Hepatology.The article was published on 2011-05-01 and is currently open access. It has received 277 citations till now. The article focuses on the topics: Cytotoxic T cell & CTLA-4.read more
Citations
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Living in the liver: hepatic infections
TL;DR: The interplay between pathogens and host factors that promote pathogen elimination and maintain organ integrity or that allow pathogen persistence are described.
Journal ArticleDOI
Hepatitis B virus infection
Man-Fung Yuen,Ding-Shinn Chen,Ding-Shinn Chen,Geoffrey Dusheiko,Harry L.A. Janssen,Daryl T.-Y. Lau,Stephen Locarnini,Marion G. Peters,Ching-Lung Lai +8 more
TL;DR: This Primer addresses several aspects of HBV infection, including epidemiology, immune pathophysiology, diagnosis, prevention and management, including antiviral agents that directly act on viral replication and immunomodulators, such as interferon therapy.
Journal ArticleDOI
Innate and adaptive immune responses in chronic hepatitis B virus infections: towards restoration of immune control of viral infection.
Antonio Bertoletti,Carlo Ferrari +1 more
TL;DR: The scenario of how HBV deals with the host immunity is presented and used to discuss how the immune response can be harnessed to potentially achieve infection control.
Journal ArticleDOI
Pathogenesis of Chronic Viral Hepatitis: Differential Roles of T cells and NK cells
TL;DR: This review summarizes the current understanding of the roles of antigen-specific and nonspecific immune cells in the pathogenesis of chronic hepatitis B and C and discusses recent findings that identify natural killer cells as regulators of T cell function and liver inflammation.
Journal ArticleDOI
Immune checkpoint blockade in infectious diseases.
TL;DR: The potential for therapeutically targeting immune checkpoint pathways in the pathogenesis of infectious diseases is discussed and the recent success of immune checkpoint blockade in cancer therapy suggests that targeting these pathways would also be effective for preventing and treating a range of infectious Diseases.
References
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Journal ArticleDOI
Lymphoproliferative Disorders with Early Lethality in Mice Deficient in Ctla-4
Paul Waterhouse,Josef M. Penninger,Emma Timms,Andrew Wakeham,Arda Shahinian,Kelvin P. Lee,Craig B. Thompson,Henrik Griesser,Tak W. Mak +8 more
TL;DR: Although CTLA-4-deficient T cells proliferated spontaneously and strongly when stimulated through the T cell receptor, they were sensitive to cell death induced by cross-linking of the Fas receptor and by gamma irradiation, and is vital for the control of lymphocyte homeostasis.
Journal ArticleDOI
Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection
Shawn D. Blackburn,Haina Shin,W. Nicholas Haining,W. Nicholas Haining,Tao Zou,Creg J. Workman,Antonio Polley,Michael R. Betts,Gordon J. Freeman,Dario A. A. Vignali,E. John Wherry +10 more
TL;DR: It is shown that exhausted CD8+ T cells are subject to complex layers of negative regulation resulting from the coexpression of multiple inhibitory receptors, and regulation of T cell exhaustion by various inhibitory pathways was nonredundant.
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EASL Clinical Practice Guidelines: Management of chronic hepatitis B
C.P.G.P.P. Marcellin,G.M. Dusheiko,Fabien Zoulim,Rafael Esteban,Stephanos J. Hadziyannis,Pietro Lampertico,M.P. Manns,Daniel Shouval,Cihan Yurdaydin,R.A. Craxi,Xavier Forns,Darius Moradpour,Jean-Michel Pawlotsky,Jörg Petersen,H.W.F. Easl +14 more
TL;DR: The objective of these EASL Clinical Practice Guidelines is to update recommendations for the optimal management of chronic hepatitis B (CHB) and the CPGs do not focus on prevention and vaccination.
Journal ArticleDOI
CTLA-4 ligation blocks CD28-dependent T cell activation.
TL;DR: The results demonstrate that the primary effect of CTLA-4 ligation is not the induction of apoptosis, but does inhibit CD28- dependent IL-2 production and cell cycle progression of activated T cells.
Journal ArticleDOI
Characterization of hepatitis B virus (HBV)-specific T-cell dysfunction in chronic HBV infection.
Carolina Boni,Paola Fisicaro,Caterina Valdatta,Barbara Amadei,Paola Di Vincenzo,Tiziana Giuberti,Diletta Laccabue,Alessandro Zerbini,A. Cavalli,Gabriele Missale,Antonio Bertoletti,Carlo Ferrari +11 more
TL;DR: A broad spectrum of anti-HBV immunity is expressed by patients with chronic HBV infection and this spectrum is proportional to HBV replication levels and can be improved by blocking the PD-1/PD-L1 pathway.