Journal ArticleDOI
Role of the pericyte in wound healing: An ultrastructural study☆
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TLDR
It is proposed that the pericyte-endothelial “contacts” act as a regulatory mechanism for capillary proliferation.About:
This article is published in Experimental and Molecular Pathology.The article was published on 1970-08-01. It has received 213 citations till now. The article focuses on the topics: Pericyte & Wound healing.read more
Citations
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Journal ArticleDOI
Pericyte Loss and Microaneurysm Formation in PDGF-B-Deficient Mice
TL;DR: Comparisons made between PDGF null mouse phenotypes suggest a general role for PDGFs in the development of myofibroblasts, and endothelial cells of the sprouting capillaries in the mutant mice appeared to be unable to attract PDGF-Rbeta-positive pericyte progenitor cells.
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Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis.
Mats Hellström,Holger Gerhardt,Holger Gerhardt,Mattias Kalén,Xuri Li,Ulf Eriksson,Hartwig Wolburg,Christer Betsholtz +7 more
TL;DR: Although PC deficiency appears to have direct effects on EC number before E 13.5, the subsequent increased VEGF-A levels may further abrogate microvessel architecture, promote vascular permeability, and contribute to formation of the edematous phenotype observed in late gestation PDGF-B and PDGFR-beta knock out embryos.
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Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-beta 1-like molecule by plasmin during co-culture.
Yasufumi Sato,Daniel B. Rifkin +1 more
TL;DR: Activation of TGF-beta 1 appears to be mediated by plasmin as the inhibitory effect on cell movement in co- cultures of BAE cells and pericytes is blocked by the inclusion of inhibitors of pl asmin in the culture medium.
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Vascular endothelial growth factors and angiogenesis in eye disease.
TL;DR: Recent findings that VEGFs secreted by epithelia, including the retinal pigment epithelium (RPE), are likely to mediate paracrine vascular survival signals for adjacent endothelia may explain the pathogenesis of subretinal neovascularisation in AMD.
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Wound healing - A literature review.
Ana Cristina Gonzalez,Tila Fortuna Costa,Zilton A. Andrade,Alena Ribeiro Alves Peixoto Medrado +3 more
TL;DR: The purpose of this review is to describe the various cellular and molecular aspects involved in the skin healing process.
References
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Journal ArticleDOI
A. The development of adventitial (Rouget) cells on the blood capillaries of amphibian larvae
Journal ArticleDOI
A diffusible factor which sustains contact inhibition of replication.
Jen Yeh,Harold W. Fisher +1 more
TL;DR: Confluent 3T3 cultures make and release into the medium a diffusible factor which sustains the state of contact inhibition of replication.
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The need for direct cell contact in "contact" inhibition of cell division in culture.
Leonard Schutz,Peter T. Mora +1 more
TL;DR: Non‐dividing mouse embryo fibroblasts which grew to a confluent cell density on one side of an ultra‐thin filter did not inhibit the active multiplication of the same type of cells growing at low cell density directly opposite the confluent side.
Related Papers (5)
Inhibition of Capillary Endothelial Cell Growth by Pericytes and Smooth Muscle Cells
A. Orlidge,Patricia A. D'Amore +1 more