Journal ArticleDOI
Sarcopenia as a predictor of prognosis in patients following hepatectomy for hepatocellular carcinoma
Norifumi Harimoto,Ken Shirabe,Y. Yamashita,Toru Ikegami,Tomoharu Yoshizumi,Yuji Soejima,Tetsuo Ikeda,Yoshihiko Maehara,Akihiro Nishie,Takahiro Yamanaka +9 more
TLDR
This study investigated the effect of sarcopenia on short‐ and long‐term outcomes following partial hepatectomy for hepatocellular carcinoma (HCC), and aimed to identify prognostic factors.Abstract:
Background: Sarcopenia was identified recently as a poor prognostic factor in patients with cancer. The present study investigated the effect of sarcopenia on short- and long-term outcomes following partial hepatectomy for hepatocellular carcinoma (HCC), and aimed to identify prognostic factors. Methods: Data were collected retrospectively for all consecutive patients who underwent hepatectomy for HCC with curative intent between January 2004 and December 2009. Patients were assigned to one of two groups according to the presence or absence of sarcopenia, assessed by computed tomographic measurement of muscle mass at the level of the third lumbar vertebra. Clinicopathological, surgical outcome and long-term survival data were analysed. Results: Sarcopenia was present in 75 (40·3 per cent) of 186 patients, and was significantly correlated with female sex, lower body mass index and liver dysfunction, as indicated by abnormal serum albumin levels and indocyanine green retention test at 15min values. In patients with, and without sarcopenia, the 5-year overall survival rate was 71 and 83·7 per cent respectively, and the 5-year recurrence-free survival rate was 13 and 33·2 per cent respectively. Multivariable analysis revealed that reduced skeletal muscle mass was predictive of an unfavourable prognosis. Conclusion: Sarcopenia was predictive of worse overall survival even when adjusted for other known predictors in patients with HCC after partial hepatectomy.read more
Citations
More filters
Journal ArticleDOI
Sarcopenia predicts survival outcomes among patients with urothelial carcinoma of the upper urinary tract undergoing radical nephroureterectomy: a retrospective multi-institution study
Hiroki Ishihara,Tsunenori Kondo,Kenji Omae,Toshio Takagi,Junpei Iizuka,Hirohito Kobayashi,Yasunobu Hashimoto,Kazunari Tanabe +7 more
TL;DR: Sarcopenia was an independent predictor of survival among patients with UCUT who were undergoing RNU as well as the relapse-free survival, cancer-specific survival, and overall survival after RNU to identify factors that predicted patient survival.
Journal ArticleDOI
Sarcopenia and Post-Operative Morbidity and Mortality in Patients with Gastric Cancer.
Stephen J. O'Brien,Maria Twomey,Fiachra Moloney,Richard G. Kavanagh,Brian W. Carey,Derek G. Power,Michael M. Maher,Owen J. O'Connor,Criostoir O'Suilleabhain +8 more
TL;DR: In patients undergoing curative resection for gastric cancer, there was a statistically significant association between sarcopenia and both decreased overall survival and serious post-operative complications.
Journal ArticleDOI
Association of Body Composition with Long-Term Survival in Non-metastatic Rectal Cancer Patients.
Jin Soo Han,Hyoseon Ryu,In Ja Park,Kyung Won Kim,Yongbin Shin,Sun Ok Kim,Seok-Byung Lim,Chan Wook Kim,Yong Sik Yoon,Jong Lyul Lee,Chang Sik Yu,Jin Cheon Kim +11 more
TL;DR: The presence of SO and a low body mass index at diagnosis are negatively associated with OS in non-metastatic rectal cancer patients, and association of SO with OS was more prominent in patients with (y)p stage 0-2 and no inflammatory status.
Journal ArticleDOI
EWGSOP2 versus EWGSOP1 for sarcopenia to predict prognosis in patients with gastric cancer after radical gastrectomy: Analysis from a large-scale prospective study
Cheng-Le Zhuang,Xian Shen,Hong-Bo Zou,Qian-Tong Dong,Hui-Yang Cai,Xiao-Lei Chen,Zhen Yu,Su-Lin Wang +7 more
TL;DR: Sarcopenia at uniform diagnosis standard was an independent risk factor for survival in patients undergoing radical gastrectomy for gastric cancer and better predicts clinical outcomes than that defined by EWGSOP1 criteria in patients with Gastric cancer after gast rectomy.
Journal ArticleDOI
The impact of sarcopenia and myosteatosis on postoperative outcomes in patients with inflammatory bowel disease
Stephen J. O'Brien,Stephen J. O'Brien,Richard G. Kavanagh,Brian W. Carey,Michael M. Maher,Michael M. Maher,Owen J. O'Connor,Owen J. O'Connor,E.J. Andrews +8 more
TL;DR: Myosteatosis was associated with increased hospital stay and increased 30-day hospital readmission rates on multivariate regression analysis, and sarcopenia and mysteatosis in IBD were not associated with clinically relevant postoperative complications.
References
More filters
Journal ArticleDOI
Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey.
TL;DR: The new complication classification appears reliable and may represent a compelling tool for quality assessment in surgery in all parts of the world.
Journal ArticleDOI
Sarcopenia: European consensus on definition and diagnosis Report of the European Working Group on Sarcopenia in Older People
Alfonso J. Cruz-Jentoft,Jean-Pierre Baeyens,Jürgen M. Bauer,Yves Boirie,Tommy Cederholm,Francesco Landi,Finbarr C. Martin,Jean-Pierre Michel,Yves Rolland,Stéphane M. Schneider,Eva Topinkova,Maurits Vandewoude,Mauro Zamboni +12 more
TL;DR: The European Working Group on Sarcopenia in Older People (EWGSOP) developed a practical clinical definition and consensus diagnostic criteria for age-related sarcopenia as discussed by the authors.
Journal ArticleDOI
A model to predict survival in patients with end‐stage liver disease
Patrick S. Kamath,Russell H. Wiesner,Michael Malinchoc,Walter K. Kremers,Terry M. Therneau,Catherine L. Kosberg,Gennaro D'Amico,E. Rolland Dickson,M.B.A. W. Ray Kim M.D. +8 more
TL;DR: The MELD scale is a reliable measure of mortality risk in patients with end‐stage liver disease and suitable for use as a disease severity index to determine organ allocation priorities in patient groups with a broader range of disease severity and etiology.
Journal ArticleDOI
Epidemiology of Sarcopenia among the Elderly in New Mexico
Richard N. Baumgartner,Kathleen M. Koehler,Dympna Gallagher,Linda J. Romero,Steven B. Heymsfield,Robert Ross,Philip J. Garry,Robert D. Lindeman +7 more
TL;DR: Some of the first estimates of the extent of the public health problem posed by sarcopenia are provided, independent of ethnicity, age, morbidity, obesity, income, and health behaviors.
Journal ArticleDOI
Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population-based study.
Carla M. Prado,Jessica R L Lieffers,Linda J. McCargar,Tony Reiman,Michael B. Sawyer,Lisa Martin,Vickie E. Baracos +6 more
TL;DR: Evidence is provided of the great variability of body composition in patients with cancer and links body composition, especially sarcopenic obesity, to clinical implications such as functional status, survival, and potentially, chemotherapy toxicity.
Related Papers (5)
Definition and classification of cancer cachexia: an international consensus
Kenneth C. H. Fearon,Florian Strasser,Stefan D. Anker,Ingvar Bosaeus,Eduardo Bruera,Robin L. Fainsinger,Aminah Jatoi,Charles L. Loprinzi,Neil MacDonald,Giovanni Mantovani,Mellar P. Davis,Maurizio Muscaritoli,Faith D. Ottery,Lukas Radbruch,Paula Ravasco,Declan Walsh,Andrew Wilcock,Stein Kaasa,Vickie E. Baracos +18 more