Journal ArticleDOI
Sarcopenia as a predictor of prognosis in patients following hepatectomy for hepatocellular carcinoma
Norifumi Harimoto,Ken Shirabe,Y. Yamashita,Toru Ikegami,Tomoharu Yoshizumi,Yuji Soejima,Tetsuo Ikeda,Yoshihiko Maehara,Akihiro Nishie,Takahiro Yamanaka +9 more
TLDR
This study investigated the effect of sarcopenia on short‐ and long‐term outcomes following partial hepatectomy for hepatocellular carcinoma (HCC), and aimed to identify prognostic factors.Abstract:
Background: Sarcopenia was identified recently as a poor prognostic factor in patients with cancer. The present study investigated the effect of sarcopenia on short- and long-term outcomes following partial hepatectomy for hepatocellular carcinoma (HCC), and aimed to identify prognostic factors. Methods: Data were collected retrospectively for all consecutive patients who underwent hepatectomy for HCC with curative intent between January 2004 and December 2009. Patients were assigned to one of two groups according to the presence or absence of sarcopenia, assessed by computed tomographic measurement of muscle mass at the level of the third lumbar vertebra. Clinicopathological, surgical outcome and long-term survival data were analysed. Results: Sarcopenia was present in 75 (40·3 per cent) of 186 patients, and was significantly correlated with female sex, lower body mass index and liver dysfunction, as indicated by abnormal serum albumin levels and indocyanine green retention test at 15min values. In patients with, and without sarcopenia, the 5-year overall survival rate was 71 and 83·7 per cent respectively, and the 5-year recurrence-free survival rate was 13 and 33·2 per cent respectively. Multivariable analysis revealed that reduced skeletal muscle mass was predictive of an unfavourable prognosis. Conclusion: Sarcopenia was predictive of worse overall survival even when adjusted for other known predictors in patients with HCC after partial hepatectomy.read more
Citations
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Low skeletal muscle density is associated with poor survival in patients who receive chemotherapy for metastatic gastric cancer.
Naomi Hayashi,Yuichi Ando,Bishal Gyawali,Tomoya Shimokata,Osamu Maeda,Masahide Fukaya,Hidemi Goto,Masato Nagino,Yasuhiro Kodera +8 more
TL;DR: CT-based analysis using Slice-O-Matic medical imaging software in patients who received S-1 plus cisplatin chemotherapy for metastatic gastric cancer confirmed that low SMD was an independent predictor of poor outcomes and is an important prognosticator of survival in patients with metastatic Gastric cancer receiving chemotherapy.
Journal ArticleDOI
Managing Sarcopenia and Its Related-Fractures to Improve Quality of Life in Geriatric Populations
TL;DR: This paper is a review on the association between sarcopenia and its related-fractures and their diagnoses and management methods to prevent fractures.
Journal ArticleDOI
Sarcopenia and the Modified Glasgow Prognostic Score are Significant Predictors of Survival Among Patients with Metastatic Renal Cell Carcinoma Who are Receiving First-Line Sunitinib Treatment
Hiroki Ishihara,Tsunenori Kondo,Kenji Omae,Toshio Takagi,Jumpei Iizuka,Hirohito Kobayashi,Kazunari Tanabe +6 more
TL;DR: Sarcopenia and mGPS can predict outcomes among patients with mRCC who are receiving first-line sunitinib treatment and was an independent predictor of shorter PFS and OS.
Journal ArticleDOI
Prognostic significance of sarcopenia in patients with hepatocellular carcinoma undergoing sorafenib therapy.
Hiroki Nishikawa,Norihiro Nishijima,Hirayuki Enomoto,Azusa Sakamoto,Akihiro Nasu,Hideyuki Komekado,Takashi Nishimura,Ryuichi Kita,Toru Kimura,Hiroko Iijima,Shuhei Nishiguchi,Yukio Osaki +11 more
TL;DR: Sarcopenia may be an indicator of poor clinical course in patients with HCC receiving sorafenib, and was identified to be an independent predictor of OS.
Journal ArticleDOI
Sarcopenia as a predictor of poor surgical and oncologic outcomes after abdominal surgery for digestive tract cancer: A prospective cohort study.
Shuze Zhang,Shanjun Tan,Yi Jiang,Qiulei Xi,Qingyang Meng,Qiulin Zhuang,Yusong Han,Xiangyu Sui,Guohao Wu +8 more
TL;DR: Sarcopenia could be used as a strong and independent prognostic factor for poor surgical and oncologic outcomes in patients after abdominal surgery for digestive tract cancer.
References
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Epidemiology of Sarcopenia among the Elderly in New Mexico
Richard N. Baumgartner,Kathleen M. Koehler,Dympna Gallagher,Linda J. Romero,Steven B. Heymsfield,Robert Ross,Philip J. Garry,Robert D. Lindeman +7 more
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Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population-based study.
Carla M. Prado,Jessica R L Lieffers,Linda J. McCargar,Tony Reiman,Michael B. Sawyer,Lisa Martin,Vickie E. Baracos +6 more
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