Journal ArticleDOI
Sarcopenia as a predictor of prognosis in patients following hepatectomy for hepatocellular carcinoma
Norifumi Harimoto,Ken Shirabe,Y. Yamashita,Toru Ikegami,Tomoharu Yoshizumi,Yuji Soejima,Tetsuo Ikeda,Yoshihiko Maehara,Akihiro Nishie,Takahiro Yamanaka +9 more
TLDR
This study investigated the effect of sarcopenia on short‐ and long‐term outcomes following partial hepatectomy for hepatocellular carcinoma (HCC), and aimed to identify prognostic factors.Abstract:
Background: Sarcopenia was identified recently as a poor prognostic factor in patients with cancer. The present study investigated the effect of sarcopenia on short- and long-term outcomes following partial hepatectomy for hepatocellular carcinoma (HCC), and aimed to identify prognostic factors. Methods: Data were collected retrospectively for all consecutive patients who underwent hepatectomy for HCC with curative intent between January 2004 and December 2009. Patients were assigned to one of two groups according to the presence or absence of sarcopenia, assessed by computed tomographic measurement of muscle mass at the level of the third lumbar vertebra. Clinicopathological, surgical outcome and long-term survival data were analysed. Results: Sarcopenia was present in 75 (40·3 per cent) of 186 patients, and was significantly correlated with female sex, lower body mass index and liver dysfunction, as indicated by abnormal serum albumin levels and indocyanine green retention test at 15min values. In patients with, and without sarcopenia, the 5-year overall survival rate was 71 and 83·7 per cent respectively, and the 5-year recurrence-free survival rate was 13 and 33·2 per cent respectively. Multivariable analysis revealed that reduced skeletal muscle mass was predictive of an unfavourable prognosis. Conclusion: Sarcopenia was predictive of worse overall survival even when adjusted for other known predictors in patients with HCC after partial hepatectomy.read more
Citations
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Clinical impact of sarcopenia assessment in patients with liver cirrhosis
Giovanni Marasco,Elton Dajti,Federico Ravaioli,Stefano Brocchi,Benedetta Rossini,Luigina Vanessa Alemanni,Giuliano Peta,Laura Bartalena,Rita Golfieri,Davide Festi,Antonio Colecchia,Matteo Renzulli +11 more
TL;DR: The aim of this review is to provide a detailed report on the pathophysiological mechanisms underlying sarcopenia in cirrhotic patients, the several imaging methods available for the assessment of sarc Openia and the clinical studies evaluating the prognostic role of sarc openia presence in cir rhotic patients.
Journal ArticleDOI
Sarcopenia as a predictor of postoperative risk of complications, mortality and length of stay following gastrointestinal oncological surgery.
TL;DR: In this article, a meta-analysis of the relationship between sarcopenia and post-operative risk is presented, and the authors conclude that sarcopenias is a predictor of postoperative risk.
Journal ArticleDOI
Prognostic impact of concurrent nonalcoholic fatty liver disease in patients with chronic hepatitis B-related hepatocellular carcinoma.
Jun Sik Yoon,Jun Sik Yoon,Hyo Young Lee,Hyo Young Lee,Sung Won Chung,S.-W. Kim,Young Chang,Young Chang,Yun Bin Lee,Eun Ju Cho,Jeong Hoon Lee,Su Jong Yu,Haeryoung Kim,Jung Hwan Yoon,Yoon Jun Kim +14 more
TL;DR: Investigation of the clinical impact of concurrent NAFLD on the prognosis of patients with CHB‐related HCC found it to be beneficial to treat both chronic hepatitis B and nonalcoholic fatty liver disease.
Journal ArticleDOI
Sarcopaenia in surgical populations: A review.
TL;DR: This review considers the current literature regarding the cause and effect of sarcopaenia, the methods by which it may be identified and the potential ways in which it might be treated, in the interest of improving outcomes for surgical patients.
Journal ArticleDOI
Low skeletal muscle mass as predictor of postoperative complications and decreased overall survival in locally advanced head and neck squamous cell carcinoma: the role of ultrasound of rectus femoris muscle.
Andrea Galli,Michele Colombo,G. Carrara,Francesca Lira Luce,Pier Luigi Paesano,Leone Giordano,Stefano Bondi,Michele Tulli,Aurora Mirabile,Francesco De Cobelli,Mario Bussi +10 more
TL;DR: RF-CSA seems a reliable method for identification of patients with low SMM in a stage III–IV HNSCC cohort, defining a subset at high-risk of 30-day complications and poorer OS.
References
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Epidemiology of Sarcopenia among the Elderly in New Mexico
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