Journal ArticleDOI
Sarcopenia as a predictor of prognosis in patients following hepatectomy for hepatocellular carcinoma
Norifumi Harimoto,Ken Shirabe,Y. Yamashita,Toru Ikegami,Tomoharu Yoshizumi,Yuji Soejima,Tetsuo Ikeda,Yoshihiko Maehara,Akihiro Nishie,Takahiro Yamanaka +9 more
TLDR
This study investigated the effect of sarcopenia on short‐ and long‐term outcomes following partial hepatectomy for hepatocellular carcinoma (HCC), and aimed to identify prognostic factors.Abstract:
Background: Sarcopenia was identified recently as a poor prognostic factor in patients with cancer. The present study investigated the effect of sarcopenia on short- and long-term outcomes following partial hepatectomy for hepatocellular carcinoma (HCC), and aimed to identify prognostic factors. Methods: Data were collected retrospectively for all consecutive patients who underwent hepatectomy for HCC with curative intent between January 2004 and December 2009. Patients were assigned to one of two groups according to the presence or absence of sarcopenia, assessed by computed tomographic measurement of muscle mass at the level of the third lumbar vertebra. Clinicopathological, surgical outcome and long-term survival data were analysed. Results: Sarcopenia was present in 75 (40·3 per cent) of 186 patients, and was significantly correlated with female sex, lower body mass index and liver dysfunction, as indicated by abnormal serum albumin levels and indocyanine green retention test at 15min values. In patients with, and without sarcopenia, the 5-year overall survival rate was 71 and 83·7 per cent respectively, and the 5-year recurrence-free survival rate was 13 and 33·2 per cent respectively. Multivariable analysis revealed that reduced skeletal muscle mass was predictive of an unfavourable prognosis. Conclusion: Sarcopenia was predictive of worse overall survival even when adjusted for other known predictors in patients with HCC after partial hepatectomy.read more
Citations
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Computed tomography-based sarcopenia in patients receiving peritoneal dialysis: Correlation with lean soft tissue and survival
TL;DR: In this paper , the results of computed tomography (CT)-based sarcopenia assessment were correlated with edema-free lean soft tissue (LST) and were associated with the prognosis of patients receiving peritoneal dialysis (PD).
Journal ArticleDOI
Impact of combined assessment of systemic inflammation and presarcopenia on survival for surgically resected esophageal cancer.
Makoto Sakai,Makoto Sohda,Hideyuki Saito,Yasunari Ubukata,Nobuhiro Nakazawa,Kengo Kuriyama,Keigo Hara,Akihiko Sano,Kyoichi Ogata,Takehiko Yokobori,Ken Shirabe,Hiroshi Saeki +11 more
TL;DR: Systemic inflammation enhanced the effect of presarcopenia on the prognosis of EC patients, and the combined assessment of those factors may have potential prognostic value for EC.
Journal ArticleDOI
Adipose tissue imaging as nutritional predictors in patients undergoing enterocutaneous fistula repair.
Konstantinos C. Fragkos,Debbie Thong,Kenneth Cheung,Helen J. Thomson,Alastair Windsor,Alec Engledow,Jonathan McCullough,Shameer Mehta,Farooq Rahman,Andrew Plumb,Simona Di Caro +10 more
TL;DR: Abdominal adiposity was strongly correlated with anthropometric parameters at the time of ECF repair, and earlier identification of patients requiring artificial nutrition at standard preoperative imaging might allow integration of nutritional optimization into initial clinical management plans reducing length of stay and improving clinical outcomes.
Journal ArticleDOI
Associations Between Relative Grip Strength and the Risk of 15 Cancer Sites
TL;DR: Grip strength relative to BMI was associated with incidence and mortality from endometrial, gallbladder, colorectal, liver, all-cause cancer, and breast and kidney cancer incidence as discussed by the authors .
Journal ArticleDOI
Muscularity Defined by the Combination of Muscle Quantity and Quality is Closely Related to Both Liver Hypertrophy and Postoperative Outcomes Following Portal Vein Embolization in Cancer Patients.
Siyuan Yao,Naoko Kamo,Kojiro Taura,Yosuke Miyachi,Sena Iwamura,Masaaki Hirata,Toshimi Kaido,Shinji Uemoto,Shinji Uemoto +8 more
TL;DR: In this paper, the impact of muscularity defined by both muscle quantity and quality on liver hypertrophy after PVE and associated outcomes after major hepatectomy in patients with hepatobiliary cancer were investigated.
References
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Epidemiology of Sarcopenia among the Elderly in New Mexico
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