Scorpion Venom: Detriments and Benefits
Shirin Ahmadi,Shirin Ahmadi,Julius M. Knerr,Lídia M. Argemí,Karla de Castro Figueiredo Bordon,Manuela Berto Pucca,Manuela Berto Pucca,Felipe Augusto Cerni,Felipe Augusto Cerni,Eliane Candiani Arantes,Figen Caliskan,Andreas Hougaard Laustsen +11 more
TLDR
This review presents both the detrimental and beneficial properties of scorpion venom toxins and discusses the newest advances within the development of novel therapies against scorpion envenoming and the therapeutic perspectives for scorpion toxins in drug discovery.Abstract:
Scorpion venom may cause severe medical complications and untimely death if injected into the human body. Neurotoxins are the main components of scorpion venom that are known to be responsible for the pathological manifestations of envenoming. Besides neurotoxins, a wide range of other bioactive molecules can be found in scorpion venoms. Advances in separation, characterization, and biotechnological approaches have enabled not only the development of more effective treatments against scorpion envenomings, but have also led to the discovery of several scorpion venom peptides with interesting therapeutic properties. Thus, scorpion venom may not only be a medical threat to human health, but could prove to be a valuable source of bioactive molecules that may serve as leads for the development of new therapies against current and emerging diseases. This review presents both the detrimental and beneficial properties of scorpion venom toxins and discusses the newest advances within the development of novel therapies against scorpion envenoming and the therapeutic perspectives for scorpion toxins in drug discovery.read more
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A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain.
John V. Lin King,Joshua J. Emrick,Mark J. S. Kelly,Volker Herzig,Glenn F. King,Katalin F. Medzihradszky,David Julius +6 more
TL;DR: A peptidergic scorpion toxin that activates TRPA1 by penetrating the plasma membrane to access the same intracellular site modified by reactive electrophiles is described, providing a striking example of convergent evolution whereby chemically disparate animal- and plant-derived irritants target the same key allosteric regulatory site to differentially modulate channel activity.
Journal ArticleDOI
IgY-based antivenom against Bothrops alternatus: Production and neutralization efficacy.
Carlos Leónidas Leiva,Adriana Cangelosi,Virginia Mariconda,Mariano Farace,Patricia Geoghegan,Luisa Brero,Mariano E. Fernandez-Miyakawa,Pablo Chacana +7 more
TL;DR: IgY‐technology may allow the production of effective and affordable antivenoms fulfilling the urgent needs of many countries where conventional manufacture is unable to provide enough availability of antivenom.
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Insights into the binding mode and functional components of the analgesic-antitumour peptide from Buthus martensii Karsch to human voltage-gated sodium channel 1.7 based on dynamic simulation analysis.
TL;DR: Computational simulation findings and prior experimental data supports the accuracy of the described mechanism, and can provide valuable information for designing potent toxin analgesics targeting hNav1.7 with high affinity.
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Scorpion species of medical importance in the Brazilian Amazon: a review to identify knowledge gaps.
Jonas Gama Martins,Gabrielle Cristina Santos,Rudi E. L. Procopio,Eliane Candiani Arantes,Karla de Castro Figueiredo Bordon +4 more
TL;DR: A systematic search using the string words “Amazon” and “scorpion” was performed on 11 databases as discussed by the authors, and 88 studies were found to be related to scorpion envenoming.
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Small Molecules in the Venom of the Scorpion Hormurus waigiensis.
TL;DR: Some non-peptide small molecule constituents of Hormurus waigiensis venom are identified using LC/MS, reversed-phase HPLC, and NMR spectroscopy, with low quantities of the amino acids glutamic acid and aspartic acid also being present.
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