Journal ArticleDOI
Selective binding of mannose-encapsulated gold nanoparticles to type 1 pili in Escherichia coli.
Chun-Cheng Lin,Yi Chun Yeh,Chan Yi Yang,Chan Long Chen,Gee Fong Chen,Chia Chun Chen,Yi-Chun Wu +6 more
TLDR
This work demonstrates that carbohydrate attached nanoparticles can be used as an efficient affinity label and a multi-ligand carrier in a biological system.Abstract:
The synthesis, characterization and biological application of mannose encapsulated gold nanoparticles (m-AuNP) are reported. m-AuNP is well dispersed and very stable without aggregation in the media of broad ion strength and pH ranges. The selective binding of m-AuNP to the mannose adhesin FimH of bacterial type 1 pili is demonstrated using transmission electron microscopy. The competition assay with free mannose suggests that m-AuNP binds FimH better than free mannose does. This work demonstrates that carbohydrate attached nanoparticles can be used as an efficient affinity label and a multi-ligand carrier in a biological system.read more
Citations
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Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology.
TL;DR: A review of gold nanoparticles can be found in this article, where the most stable metal nanoparticles, called gold colloids (AuNPs), have been used for catalysis and biology applications.
Journal ArticleDOI
Integrated Nanoparticle–Biomolecule Hybrid Systems: Synthesis, Properties, and Applications
Eugenii Katz,Itamar Willner +1 more
TL;DR: This review describes recent advances in the synthesis of biomolecule-nanoparticle/nanorod hybrid systems and the application of such assemblies in the generation of 2D and 3D ordered structures in solutions and on surfaces.
Journal ArticleDOI
PEGylated Nanoparticles for Biological and Pharmaceutical Applications
TL;DR: The potential utility of multimolecular assembly derived from heterobifunctional PEGs and block copolymers were explored to systematically modify the properties of metal and semiconductor nanostructures by controlling their structure and their surface properties, making them extremely attractive for use in biological and biomedical applications.
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Bioapplications of RAFT polymerization.
TL;DR: The control of molecular weight and molecular weight distribution has enabled access to complex architectures and site specific functionality that were previously impossible to achieve via traditional free radical polymerizations.
Journal ArticleDOI
Functionalisation of nanoparticles for biomedical applications
TL;DR: Nanoparticles with cores composed of inorganic materials such as noble, magnetic metals, their alloys and oxides, and semiconductors have been most studied and have vast potential for application in many different areas of biomedicine.
References
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Semiconductor Nanocrystals as Fluorescent Biological Labels
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Quantum Dot Bioconjugates for Ultrasensitive Nonisotopic Detection
Warren C. W. Chan,Shuming Nie +1 more
TL;DR: Highly luminescent semiconductor quantum dots (zinc sulfide-capped cadmium selenide) have been covalently coupled to biomolecules for use in ultrasensitive biological detection and these nanometer-sized conjugates are water-soluble and biocompatible.
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