Selenium and tellurium-based nanoparticles as interfering factors in quorum sensing-regulated processes: violacein production and bacterial biofilm formation.
Beatriz Gómez-Gómez,Lucía Arregui,Susana Serrano,Antonio Santos,Teresa Pérez-Corona,Yolanda Madrid +5 more
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TLDR
An important disruption of the QS signalling system by SeNPs and TeNPs is suggested, supporting nanotechnology as a promising tool to fight against the emerging problem of bacterial resistance related to bacterial biofilm formation.Abstract:
A cell-to-cell communication system called quorum sensing (QS) promotes the transcription of certain target genes in bacterial cells leading to the activation of different cellular processes, some of them related to bacterial biofilm formation. The formation of bacterial biofilms favours antibiotic resistance, which is nowadays a significant public-health problem. In this study, the effect of selenium (SeNPs) and tellurium (TeNPs) nanoparticles was examined in two bacterial processes mediated by QS: violacein production by Chromobacterium violaceum and biofilm formation by Pseudomonas aeruginosa. For this purpose, quantification of the pigment production in the presence of these nanoparticles was monitored using the C. violaceum strain. Additionally, a combination of different microscopical imaging techniques was applied to examine the changes in the 3D biofilm structure of P. aeruginosa, which were quantified through performing architectural metric calculations (substratum area, cell area coverage and biovolume). SeNPs produce an 80% inhibition in the violacein production by C. violaceum and a significant effect on the P. aeruginosa biofilm architecture (a reduction of 80% in the biovolume of the bacterial biofilm was obtained). TeNPs similarly affect violacein production and the P. aeruginosa biofilm structure but at lower concentration levels. The results obtained suggest an important disruption of the QS signalling system by SeNPs and TeNPs, supporting nanotechnology as a promising tool to fight against the emerging problem of bacterial resistance related to bacterial biofilm formation.read more
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Nanomaterial-based therapeutics for antibiotic-resistant bacterial infections
Jessa Marie Makabenta,Ahmed Nabawy,Cheng-Hsuan Li,Suzannah M. Schmidt-Malan,Robin Patel,Vincent M. Rotello +5 more
TL;DR: The mechanisms by which nanomaterials can be used to target antibiotic-resistant bacterial infections are discussed, design elements and properties of nanomMaterials that can be engineered to enhance potency are highlighted, and recent progress and remaining challenges for clinical implementation are explored.
Journal ArticleDOI
Green Synthesis of Selenium and Tellurium Nanoparticles: Current Trends, Biological Properties and Biomedical Applications
Marjorie C Zambonino,Ernesto Mateo Quizhpe,Francisco E. Jaramillo,Ashiqur Rahman,Nelson Santiago Vispo,Clayton Jeffryes,Si Amar Dahoumane,Si Amar Dahoumane +7 more
TL;DR: In this paper, the authors extensively review the eco-friendly production of metalloid nanoparticles, namely made of selenium (SeNPs) and tellurium (TeNPs), using various microorganisms, such as bacteria and fungi, and plants' extracts.
Journal ArticleDOI
Developments in the study and applications of bacterial transformations of selenium species.
Jesus J. Ojeda,Mohamed L. Merroun,Anna V. Tugarova,Silvia Lampis,Alexander A. Kamnev,Philip H. E. Gardiner +5 more
TL;DR: The focus of this review is to present the state-of-the-art of all aspects of the investigations into the bacterial transformations of selenium species, and to consider the characterization and biotechnological uses of these transformations and their products.
Journal ArticleDOI
Niosome-encapsulated tobramycin reduced antibiotic resistance and enhanced antibacterial activity against multidrug-resistant clinical strains of Pseudomonas aeruginosa.
Mojtaba Hedayati Ch,Arefeh Abolhassani Targhi,Farzaneh Shamsi,Fatemeh Heidari,Zahra Salehi Moghadam,Amir Mirzaie,Reyhaneh Behdad,Maryam Moghtaderi,Iman Akbarzadeh +8 more
TL;DR: The finding of the study shows that encapsulation of tobramycin in niosome enhanced the antibacterial activity and reduced antibiotic resistance in MDR strains of P. aeruginosa comparing to free tobramYcin and it can be considered as a favorable drug delivery system.
Journal ArticleDOI
Combined single cell and single particle ICP-TQ-MS analysis to quantitatively evaluate the uptake and biotransformation of tellurium nanoparticles in bacteria.
Beatriz Gómez-Gómez,Mario Corte-Rodríguez,Ma Teresa Perez-Corona,Jörg Bettmer,Maria Montes-Bayón,Yolanda Madrid +5 more
TL;DR: To the best of this knowledge, this is the first time that SC/SP-ICP-TQ-MS along with TEM and XRD analysis have been applied to investigate, quantitatively, nanoparticle uptake in bacterial cells and to estimate the dimensions of biogenic Te nanorods.
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